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Protein

Solute carrier family 25 member 38 homolog

Gene

PGUG_00074

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial carrier required for the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:PGUG_00074
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 41Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei70 – 96Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei123 – 148Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei180 – 203Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei226 – 252Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei284 – 302Helical; Name=6UniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789411 – 317Solute carrier family 25 member 38 homologAdd BLAST317

Structurei

3D structure databases

ProteinModelPortaliA5D9W9.
SMRiA5D9W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 95Solcar 1Add BLAST86
Repeati117 – 205Solcar 2Add BLAST89
Repeati222 – 309Solcar 3Add BLAST88

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766. Eukaryota.
ENOG410XRMK. LUCA.
InParanoidiA5D9W9.
KOiK15118.
OrthoDBiEOG092C3NVU.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

A5D9W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTTPEVKP GTTLHLLAGS SAGLISAFTL QPFDLLKTRL QQQQRANVGY
60 70 80 90 100
RSSISRELKK LARFKDLWRG ALPSTLRTSV GAGLYFTILS QTRTYVAQLR
110 120 130 140 150
ARTDKLPHSQ TSVLPKLSAL DNLSAGFVVR AVVGFITMPI TIIKTRFESN
160 170 180 190 200
MYNYNSMYEG VEGIYLDGKE KGSLRNFFKG TIATLARDCP YAGLYVLFYE
210 220 230 240 250
SMKNEFVPKT LILFDQQEQL ENSTLVNSSA AVVASSLATT ITAPFDAIKT
260 270 280 290 300
RLQLDSHTVG GNSIMSVTKQ LLKEDGGVRN LFRGLSLRFG RKGLSAAISW
310
CIYEELLKSG RLQRLLH
Length:317
Mass (Da):35,092
Last modified:July 22, 2008 - v2
Checksum:i2BAEA7F710DABBDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408155 Genomic DNA. Translation: EDK35976.2.
RefSeqiXP_001486697.1. XM_001486647.1.

Genome annotation databases

EnsemblFungiiEDK35976; EDK35976; PGUG_00074.
GeneIDi5128750.
KEGGipgu:PGUG_00074.

Similar proteinsi

Entry informationi

Entry nameiS2538_PICGU
AccessioniPrimary (citable) accession number: A5D9W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 22, 2008
Last modified: July 5, 2017
This is version 54 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families