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Protein

Mitochondrial glycine transporter

Gene

PGUG_00074

Organism
Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:PGUG_00074
OrganismiMeyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)
Taxonomic identifieri294746 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeMeyerozyma
Proteomesi
  • UP000001997 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 41Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei70 – 96Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei123 – 148Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei180 – 203Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei226 – 252Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei284 – 302Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789411 – 317Mitochondrial glycine transporterAdd BLAST317

Structurei

3D structure databases

ProteinModelPortaliA5D9W9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 95Solcar 1UniRule annotationAdd BLAST86
Repeati117 – 205Solcar 2UniRule annotationAdd BLAST89
Repeati222 – 309Solcar 3UniRule annotationAdd BLAST88

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766 Eukaryota
ENOG410XRMK LUCA
InParanoidiA5D9W9
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

A5D9W9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTTPEVKP GTTLHLLAGS SAGLISAFTL QPFDLLKTRL QQQQRANVGY
60 70 80 90 100
RSSISRELKK LARFKDLWRG ALPSTLRTSV GAGLYFTILS QTRTYVAQLR
110 120 130 140 150
ARTDKLPHSQ TSVLPKLSAL DNLSAGFVVR AVVGFITMPI TIIKTRFESN
160 170 180 190 200
MYNYNSMYEG VEGIYLDGKE KGSLRNFFKG TIATLARDCP YAGLYVLFYE
210 220 230 240 250
SMKNEFVPKT LILFDQQEQL ENSTLVNSSA AVVASSLATT ITAPFDAIKT
260 270 280 290 300
RLQLDSHTVG GNSIMSVTKQ LLKEDGGVRN LFRGLSLRFG RKGLSAAISW
310
CIYEELLKSG RLQRLLH
Length:317
Mass (Da):35,092
Last modified:July 22, 2008 - v2
Checksum:i2BAEA7F710DABBDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH408155 Genomic DNA Translation: EDK35976.2
RefSeqiXP_001486697.1, XM_001486647.1

Genome annotation databases

EnsemblFungiiEDK35976; EDK35976; PGUG_00074
GeneIDi5128750
KEGGipgu:PGUG_00074

Similar proteinsi

Entry informationi

Entry nameiS2538_PICGU
AccessioniPrimary (citable) accession number: A5D9W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 22, 2008
Last modified: April 25, 2018
This is version 59 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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