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A5D9H7 (UBP12_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 12

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 12
Ubiquitin thioesterase 12
Ubiquitin-specific-processing protease 12
Gene names
Name:USP12
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length369 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2 By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with WDR48 By similarity.

Sequence similarities

Belongs to the peptidase C19 family. USP12/USP46 subfamily.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 369369Ubiquitin carboxyl-terminal hydrolase 12
PRO_0000378990

Regions

Domain39 – 368330USP

Sites

Active site481Nucleophile By similarity
Active site3161Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A5D9H7 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: E0AC3405433BB353

FASTA36942,683
        10         20         30         40         50         60 
MEILMTVSKL ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC 

        70         80         90        100        110        120 
RPFREKVLAY KSQPRKKESL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY 

       130        140        150        160        170        180 
MQQDAHEFLN YLLNTIADIL QEERKQEKQN GRLPNGNIDS ENNSTPDPTW VHEIFQGTLT 

       190        200        210        220        230        240 
NETRCLTCET ISSKDEDFLD LSVDVEQNTS ITHCLRGFSN TETLCSEYKY YCEECRSKQE 

       250        260        270        280        290        300 
AHKRMKVKKL PMILALHLKR FKYMDQLHRY TKLSYRVVFP LELRLFNTSG DATNPDRMYD 

       310        320        330        340        350        360 
LVAVVVHCGS GPNRGHYIAI VKSHDFWLLF DDDIVEKIDA QAIEEFYGLT SDISKNSESG 


YILFYQSRD 

« Hide

References

[1]"Characterization of 954 bovine full-CDS cDNA sequences."
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L., Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.
BMC Genomics 6:166-166(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT030596 mRNA. Translation: ABQ13036.1.
RefSeqNP_001091528.1. NM_001098059.1.
UniGeneBt.24513.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000022828.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000022828; ENSBTAP00000022828; ENSBTAG00000017179.
GeneID525655.
KEGGbta:525655.

Organism-specific databases

CTD219333.

Phylogenomic databases

eggNOGCOG5077.
GeneTreeENSGT00650000093027.
HOGENOMHOG000231498.
InParanoidA5D9H7.
KOK11842.
OMASKFASFC.
OrthoDBEOG7RBZ8G.
TreeFamTF314144.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20874210.

Entry information

Entry nameUBP12_BOVIN
AccessionPrimary (citable) accession number: A5D9H7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: June 12, 2007
Last modified: April 16, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries