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Protein

Vacuolar protein sorting-associated protein 37C

Gene

VPS37C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • protein dimerization activity Source: InterPro

GO - Biological processi

  • endosomal transport Source: Reactome
  • intracellular transport of virus Source: Reactome
  • macroautophagy Source: ParkinsonsUK-UCL
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • protein transport Source: UniProtKB-KW
  • viral budding via host ESCRT complex Source: ParkinsonsUK-UCL
  • viral life cycle Source: Reactome

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588. Budding and maturation of HIV virion.
R-HSA-174490. Membrane binding and targetting of GAG proteins.
R-HSA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37C
Short name:
hVps37C
Alternative name(s):
ESCRT-I complex subunit VPS37C
Gene namesi
Name:VPS37C
Synonyms:PML39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26097. VPS37C.

Subcellular locationi

GO - Cellular componenti

  • endosome membrane Source: Reactome
  • ESCRT I complex Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55048.
OpenTargetsiENSG00000167987.
PharmGKBiPA142670617.

Polymorphism and mutation databases

BioMutaiVPS37C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121981 – 355Vacuolar protein sorting-associated protein 37CAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by TBK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA5D8V6.
MaxQBiA5D8V6.
PaxDbiA5D8V6.
PRIDEiA5D8V6.

PTM databases

iPTMnetiA5D8V6.
PhosphoSitePlusiA5D8V6.

Expressioni

Gene expression databases

BgeeiENSG00000167987.
CleanExiHS_VPS37C.
ExpressionAtlasiA5D8V6. baseline and differential.
GenevisibleiA5D8V6. HS.

Organism-specific databases

HPAiHPA043348.

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2. Interacts with CEP55.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • protein dimerization activity Source: InterPro

Protein-protein interaction databases

BioGridi120371. 38 interactors.
IntActiA5D8V6. 96 interactors.
MINTiMINT-6173488.
STRINGi9606.ENSP00000301765.

Structurei

3D structure databases

ProteinModelPortaliA5D8V6.
SMRiA5D8V6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 167VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi171 – 353Pro-richAdd BLAST183

Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

eggNOGiKOG3270. Eukaryota.
ENOG4111UJN. LUCA.
GeneTreeiENSGT00530000063123.
HOGENOMiHOG000234744.
HOVERGENiHBG073355.
InParanoidiA5D8V6.
KOiK12185.
OMAiGYSWSPQ.
OrthoDBiEOG091G0GMF.
PhylomeDBiA5D8V6.
TreeFamiTF321840.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiView protein in InterPro
IPR011598. bHLH_dom.
IPR009851. Mod_r.
PfamiView protein in Pfam
PF07200. Mod_r. 1 hit.
PROSITEiView protein in PROSITE
PS51314. VPS37_C. 1 hit.

Sequencei

Sequence statusi: Complete.

A5D8V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLKDKTLQ ELEELQNDSE AIDQLALESP EVQDLQLERE MALATNRSLA
60 70 80 90 100
ERNLEFQGPL EISRSNLSDR YQELRKLVER CQEQKAKLEK FSSALQPGTL
110 120 130 140 150
LDLLQVEGMK IEEESEAMAE KFLEGEVPLE TFLENFSSMR MLSHLRRVRV
160 170 180 190 200
EKLQEVVRKP RASQELAGDA PPPRPPPPVR PVPQGTPPVV EEQPQPPLAM
210 220 230 240 250
PPYPLPYSPS PSLPVGPTAH GALPPAPFPV VSQPSFYSGP LGPTYPAAQL
260 270 280 290 300
GPRGAAGYSW SPQRSMPPRP GYPGTPMGAS GPGYPLRGGR APSPGYPQQS
310 320 330 340 350
PYPATGGKPP YPIQPQLPSF PGQPQPSVPL QPPYPPGPAP PYGFPPPPGP

AWPGY
Length:355
Mass (Da):38,659
Last modified:November 30, 2010 - v2
Checksum:i1DE18F0E4C7C7E2E
GO

Sequence cautioni

The sequence CAD38936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037451182V → D1 PublicationCorresponds to variant dbSNP:rs2232142Ensembl.1
Natural variantiVAR_037452198L → S2 PublicationsCorresponds to variant dbSNP:rs754382Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834261 mRNA. Translation: CAD38936.1. Different initiation.
AP000437 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73925.1.
BC141827 mRNA. Translation: AAI41828.1.
BC142702 mRNA. Translation: AAI42703.1.
CCDSiCCDS31573.1.
RefSeqiNP_060436.4. NM_017966.4.
XP_005274134.1. XM_005274077.3.
UniGeneiHs.523715.

Genome annotation databases

EnsembliENST00000301765; ENSP00000301765; ENSG00000167987.
GeneIDi55048.
KEGGihsa:55048.
UCSCiuc001nqv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiVP37C_HUMAN
AccessioniPrimary (citable) accession number: A5D8V6
Secondary accession number(s): Q8N3K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 30, 2010
Last modified: July 5, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families