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Protein

Vacuolar protein sorting-associated protein 37C

Gene

VPS37C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB

GO - Biological processi

  • endosomal transport Source: Reactome
  • endosome transport via multivesicular body sorting pathway Source: InterPro
  • intracellular transport of virus Source: Reactome
  • macroautophagy Source: ParkinsonsUK-UCL
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • protein transport Source: UniProtKB-KW
  • viral budding via host ESCRT complex Source: ParkinsonsUK-UCL
  • viral life cycle Source: Reactome

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588 Budding and maturation of HIV virion
R-HSA-174490 Membrane binding and targetting of GAG proteins
R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT)

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37C
Short name:
hVps37C
Alternative name(s):
ESCRT-I complex subunit VPS37C
Gene namesi
Name:VPS37C
Synonyms:PML39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000167987.10
HGNCiHGNC:26097 VPS37C
MIMi610038 gene
neXtProtiNX_A5D8V6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55048
OpenTargetsiENSG00000167987
PharmGKBiPA142670617

Polymorphism and mutation databases

BioMutaiVPS37C

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121981 – 355Vacuolar protein sorting-associated protein 37CAdd BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by TBK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA5D8V6
MaxQBiA5D8V6
PaxDbiA5D8V6
PRIDEiA5D8V6

PTM databases

iPTMnetiA5D8V6
PhosphoSitePlusiA5D8V6

Expressioni

Gene expression databases

BgeeiENSG00000167987
CleanExiHS_VPS37C
ExpressionAtlasiA5D8V6 baseline and differential
GenevisibleiA5D8V6 HS

Organism-specific databases

HPAiHPA043348

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoichiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoichiometry. Interacts with HGS and STAM2. Interacts with CEP55.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120371, 59 interactors
CORUMiA5D8V6
IntActiA5D8V6, 95 interactors
MINTiA5D8V6
STRINGi9606.ENSP00000301765

Structurei

3D structure databases

ProteinModelPortaliA5D8V6
SMRiA5D8V6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 167VPS37 C-terminalPROSITE-ProRule annotationAdd BLAST90

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi171 – 353Pro-richAdd BLAST183

Sequence similaritiesi

Belongs to the VPS37 family.Curated

Phylogenomic databases

eggNOGiKOG3270 Eukaryota
ENOG4111UJN LUCA
GeneTreeiENSGT00530000063123
HOGENOMiHOG000234744
HOVERGENiHBG073355
InParanoidiA5D8V6
KOiK12185
OMAiGYSWSPQ
OrthoDBiEOG091G0GMF
PhylomeDBiA5D8V6
TreeFamiTF321840

Family and domain databases

InterProiView protein in InterPro
IPR037202 ESCRT_assembly_dom
IPR009851 Mod_r
IPR037859 Vps37
PANTHERiPTHR13678 PTHR13678, 1 hit
PfamiView protein in Pfam
PF07200 Mod_r, 1 hit
SUPFAMiSSF140111 SSF140111, 1 hit
PROSITEiView protein in PROSITE
PS51314 VPS37_C, 1 hit

Sequencei

Sequence statusi: Complete.

A5D8V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLKDKTLQ ELEELQNDSE AIDQLALESP EVQDLQLERE MALATNRSLA
60 70 80 90 100
ERNLEFQGPL EISRSNLSDR YQELRKLVER CQEQKAKLEK FSSALQPGTL
110 120 130 140 150
LDLLQVEGMK IEEESEAMAE KFLEGEVPLE TFLENFSSMR MLSHLRRVRV
160 170 180 190 200
EKLQEVVRKP RASQELAGDA PPPRPPPPVR PVPQGTPPVV EEQPQPPLAM
210 220 230 240 250
PPYPLPYSPS PSLPVGPTAH GALPPAPFPV VSQPSFYSGP LGPTYPAAQL
260 270 280 290 300
GPRGAAGYSW SPQRSMPPRP GYPGTPMGAS GPGYPLRGGR APSPGYPQQS
310 320 330 340 350
PYPATGGKPP YPIQPQLPSF PGQPQPSVPL QPPYPPGPAP PYGFPPPPGP

AWPGY
Length:355
Mass (Da):38,659
Last modified:November 30, 2010 - v2
Checksum:i1DE18F0E4C7C7E2E
GO

Sequence cautioni

The sequence CAD38936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037451182V → D1 PublicationCorresponds to variant dbSNP:rs2232142Ensembl.1
Natural variantiVAR_037452198L → S2 PublicationsCorresponds to variant dbSNP:rs754382Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834261 mRNA Translation: CAD38936.1 Different initiation.
AP000437 Genomic DNA No translation available.
CH471076 Genomic DNA Translation: EAW73925.1
BC141827 mRNA Translation: AAI41828.1
BC142702 mRNA Translation: AAI42703.1
CCDSiCCDS31573.1
RefSeqiNP_060436.4, NM_017966.4
XP_005274134.1, XM_005274077.3
UniGeneiHs.523715

Genome annotation databases

EnsembliENST00000301765; ENSP00000301765; ENSG00000167987
GeneIDi55048
KEGGihsa:55048
UCSCiuc001nqv.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVP37C_HUMAN
AccessioniPrimary (citable) accession number: A5D8V6
Secondary accession number(s): Q8N3K4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 30, 2010
Last modified: March 28, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health