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Protein

Vacuolar protein sorting-associated protein 37C

Gene

VPS37C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB

GO - Biological processi

  • autophagy Source: ParkinsonsUK-UCL
  • endosomal transport Source: Reactome
  • intracellular transport of virus Source: Reactome
  • multivesicular body assembly Source: ParkinsonsUK-UCL
  • protein transport Source: UniProtKB-KW
  • viral budding via host ESCRT complex Source: ParkinsonsUK-UCL
  • viral life cycle Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-162588. Budding and maturation of HIV virion.
R-HSA-174490. Membrane binding and targetting of GAG proteins.
R-HSA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 37C
Short name:
hVps37C
Alternative name(s):
ESCRT-I complex subunit VPS37C
Gene namesi
Name:VPS37C
Synonyms:PML39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26097. VPS37C.

Subcellular locationi

GO - Cellular componenti

  • endosome membrane Source: Reactome
  • ESCRT I complex Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670617.

Polymorphism and mutation databases

BioMutaiVPS37C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Vacuolar protein sorting-associated protein 37CPRO_0000312198Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by TBK1.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA5D8V6.
MaxQBiA5D8V6.
PaxDbiA5D8V6.
PRIDEiA5D8V6.

PTM databases

iPTMnetiA5D8V6.
PhosphoSiteiA5D8V6.

Expressioni

Gene expression databases

BgeeiA5D8V6.
CleanExiHS_VPS37C.
ExpressionAtlasiA5D8V6. baseline and differential.
GenevisibleiA5D8V6. HS.

Organism-specific databases

HPAiHPA043348.

Interactioni

Subunit structurei

Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and MVB12A or MVB12B in a 1:1:1:1 stoechiometry. Interacts with TSG101, VPS28, MVB12A and MVB12B. Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of TSG101, VPS28, a VPS37 protein (VPS37A to -D) and UBAP1 in a 1:1:1:1 stoechiometry. Interacts with HGS and STAM2. Interacts with CEP55.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AESQ081173EBI-2559305,EBI-717810
C1orf94Q6P1W53EBI-2559305,EBI-946029
CEP55D3DR373EBI-2559305,EBI-10173536
DAZAP2Q150383EBI-2559305,EBI-724310
DDIT3P35638-23EBI-2559305,EBI-10173632
FAM168AQ925673EBI-2559305,EBI-7957930
GOLGA2Q083793EBI-2559305,EBI-618309
HGSO149643EBI-2559305,EBI-740220
HNRNPUL1Q9BUJ23EBI-2559305,EBI-1018153
MAPK1IP1LQ8NDC03EBI-2559305,EBI-741424
PDCD6O753403EBI-2559305,EBI-352915
PKNOX1Q96I873EBI-2559305,EBI-10173774
PLSCR1O151623EBI-2559305,EBI-740019
PSMA3P257883EBI-2559305,EBI-348380
RBPMSQ930623EBI-2559305,EBI-740322
RFX6Q8HWS33EBI-2559305,EBI-746118
RINT1Q6NUQ13EBI-2559305,EBI-726876
SH3GL1Q6FGM03EBI-2559305,EBI-10173690
SORBS2O948753EBI-2559305,EBI-311323
SORBS3O605043EBI-2559305,EBI-741237
STAM2O758863EBI-2559305,EBI-373258
TACC3Q9Y6A53EBI-2559305,EBI-2554984
TFGQ927343EBI-2559305,EBI-357061
TFIP11Q9UBB93EBI-2559305,EBI-1105213
TSG101Q998163EBI-2559305,EBI-346882
WWP2O003083EBI-2559305,EBI-743923
XIAPP981703EBI-2559305,EBI-517127

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi120371. 38 interactions.
IntActiA5D8V6. 32 interactions.
MINTiMINT-6173488.
STRINGi9606.ENSP00000301765.

Structurei

3D structure databases

ProteinModelPortaliA5D8V6.
SMRiA5D8V6. Positions 109-150.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 16790VPS37 C-terminalPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi171 – 353183Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the VPS37 family.Curated
Contains 1 VPS37 C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3270. Eukaryota.
ENOG4111UJN. LUCA.
GeneTreeiENSGT00530000063123.
HOGENOMiHOG000234744.
HOVERGENiHBG073355.
InParanoidiA5D8V6.
KOiK12185.
OMAiSWSPQRS.
OrthoDBiEOG7KQ22B.
PhylomeDBiA5D8V6.
TreeFamiTF321840.

Family and domain databases

InterProiIPR009851. Mod_r.
[Graphical view]
PfamiPF07200. Mod_r. 1 hit.
[Graphical view]
PROSITEiPS51314. VPS37_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5D8V6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLKDKTLQ ELEELQNDSE AIDQLALESP EVQDLQLERE MALATNRSLA
60 70 80 90 100
ERNLEFQGPL EISRSNLSDR YQELRKLVER CQEQKAKLEK FSSALQPGTL
110 120 130 140 150
LDLLQVEGMK IEEESEAMAE KFLEGEVPLE TFLENFSSMR MLSHLRRVRV
160 170 180 190 200
EKLQEVVRKP RASQELAGDA PPPRPPPPVR PVPQGTPPVV EEQPQPPLAM
210 220 230 240 250
PPYPLPYSPS PSLPVGPTAH GALPPAPFPV VSQPSFYSGP LGPTYPAAQL
260 270 280 290 300
GPRGAAGYSW SPQRSMPPRP GYPGTPMGAS GPGYPLRGGR APSPGYPQQS
310 320 330 340 350
PYPATGGKPP YPIQPQLPSF PGQPQPSVPL QPPYPPGPAP PYGFPPPPGP

AWPGY
Length:355
Mass (Da):38,659
Last modified:November 30, 2010 - v2
Checksum:i1DE18F0E4C7C7E2E
GO

Sequence cautioni

The sequence CAD38936.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti182 – 1821V → D.1 Publication
Corresponds to variant rs2232142 [ dbSNP | Ensembl ].
VAR_037451
Natural varianti198 – 1981L → S.2 Publications
Corresponds to variant rs754382 [ dbSNP | Ensembl ].
VAR_037452
Natural varianti261 – 2611S → A.
Corresponds to variant rs4297482 [ dbSNP | Ensembl ].
VAR_037453

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834261 mRNA. Translation: CAD38936.1. Different initiation.
AP000437 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73925.1.
BC141827 mRNA. Translation: AAI41828.1.
BC142702 mRNA. Translation: AAI42703.1.
CCDSiCCDS31573.1.
RefSeqiNP_060436.4. NM_017966.4.
XP_005274134.1. XM_005274077.2.
UniGeneiHs.523715.

Genome annotation databases

EnsembliENST00000301765; ENSP00000301765; ENSG00000167987.
GeneIDi55048.
KEGGihsa:55048.
UCSCiuc001nqv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL834261 mRNA. Translation: CAD38936.1. Different initiation.
AP000437 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW73925.1.
BC141827 mRNA. Translation: AAI41828.1.
BC142702 mRNA. Translation: AAI42703.1.
CCDSiCCDS31573.1.
RefSeqiNP_060436.4. NM_017966.4.
XP_005274134.1. XM_005274077.2.
UniGeneiHs.523715.

3D structure databases

ProteinModelPortaliA5D8V6.
SMRiA5D8V6. Positions 109-150.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120371. 38 interactions.
IntActiA5D8V6. 32 interactions.
MINTiMINT-6173488.
STRINGi9606.ENSP00000301765.

PTM databases

iPTMnetiA5D8V6.
PhosphoSiteiA5D8V6.

Polymorphism and mutation databases

BioMutaiVPS37C.

Proteomic databases

EPDiA5D8V6.
MaxQBiA5D8V6.
PaxDbiA5D8V6.
PRIDEiA5D8V6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301765; ENSP00000301765; ENSG00000167987.
GeneIDi55048.
KEGGihsa:55048.
UCSCiuc001nqv.2. human.

Organism-specific databases

CTDi55048.
GeneCardsiVPS37C.
H-InvDBHIX0009681.
HGNCiHGNC:26097. VPS37C.
HPAiHPA043348.
MIMi610038. gene.
neXtProtiNX_A5D8V6.
PharmGKBiPA142670617.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3270. Eukaryota.
ENOG4111UJN. LUCA.
GeneTreeiENSGT00530000063123.
HOGENOMiHOG000234744.
HOVERGENiHBG073355.
InParanoidiA5D8V6.
KOiK12185.
OMAiSWSPQRS.
OrthoDBiEOG7KQ22B.
PhylomeDBiA5D8V6.
TreeFamiTF321840.

Enzyme and pathway databases

ReactomeiR-HSA-162588. Budding and maturation of HIV virion.
R-HSA-174490. Membrane binding and targetting of GAG proteins.
R-HSA-917729. Endosomal Sorting Complex Required For Transport (ESCRT).

Miscellaneous databases

ChiTaRSiVPS37C. human.
GenomeRNAii55048.
PROiA5D8V6.
SOURCEiSearch...

Gene expression databases

BgeeiA5D8V6.
CleanExiHS_VPS37C.
ExpressionAtlasiA5D8V6. baseline and differential.
GenevisibleiA5D8V6. HS.

Family and domain databases

InterProiIPR009851. Mod_r.
[Graphical view]
PfamiPF07200. Mod_r. 1 hit.
[Graphical view]
PROSITEiPS51314. VPS37_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-182.
    Tissue: Amygdala.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-198.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-198.
  5. "Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding."
    Eastman S.W., Martin-Serrano J., Chung W., Zang T., Bieniasz P.D.
    J. Biol. Chem. 280:628-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH HGS; STAM2 AND TSG101, SUBCELLULAR LOCATION.
  6. "Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding."
    Morita E., Sandrin V., Alam S.L., Eckert D.M., Gygi S.P., Sundquist W.I.
    Cell Host Microbe 2:41-53(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TSG101; VPS28; MVB12A AND MVB12B, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis."
    Morita E., Sandrin V., Chung H.Y., Morham S.G., Gygi S.P., Rodesch C.K., Sundquist W.I.
    EMBO J. 26:4215-4227(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CEP55.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I."
    Da Q., Yang X., Xu Y., Gao G., Cheng G., Tang H.
    J. Immunol. 186:3023-3030(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY TBK1.
  10. Cited for: IDENTIFICATION IN AN ESCRT-I COMPLEX WITH UBAP1, SUBUNIT.

Entry informationi

Entry nameiVP37C_HUMAN
AccessioniPrimary (citable) accession number: A5D8V6
Secondary accession number(s): Q8N3K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 30, 2010
Last modified: June 8, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.