A5D8S8 (HEXIM_DANRE) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 1, 2013.
Version 38.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein HEXIM | ||||
| Gene names |
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| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome] | ||||
| Taxonomic identifier | 7955 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio![]() |
Protein attributes
| Sequence length | 319 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Probable transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the HEXIM family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Coiled coil |
| Molecular function | Repressor |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: InterPro transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular_component | cytoplasm Inferred from electronic annotation. Source: InterPro nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | cyclin-dependent protein serine/threonine kinase inhibitor activity Inferred from electronic annotation. Source: InterPro snRNA bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | BC141797 mRNA. Translation: AAI41798.1. |
| IPI | IPI00631045. |
| RefSeq | NP_001091859.1. NM_001098389.1. |
| UniGene | Dr.80032. |
3D structure databases | |
| ProteinModelPortal | A5D8S8. |
| SMR | A5D8S8. Positions 216-302. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 7955.ENSDARP00000053002. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 562319. |
| KEGG | dre:562319. |
Organism-specific databases | |
| CTD | 10614. |
| ZFIN | ZDB-GENE-030131-4637. hexim1. |
Phylogenomic databases | |
| eggNOG | NOG72325. |
| HOGENOM | HOG000060338. |
| HOVERGEN | HBG053249. |
| InParanoid | A5D8S8. |
| KO | K15189. |
| OrthoDB | EOG40GCRK. |
Family and domain databases | |
| InterPro | IPR024872. HEXIM. [Graphical view] |
| PANTHER | PTHR13469. PTHR13469. 1 hit. |
| PRINTS | PR02094. HEXIMFAMILY. |
| ProtoNet | Search... |
Other | |
| NextBio | 20884347. |
Entry information
| Entry name | HEXIM_DANRE | ||||||||
| Accession | Primary (citable) accession number: A5D8S8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with
