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Protein

Probable histidine--tRNA ligase, mitochondrial

Gene

HARS2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histidine--tRNA ligase, mitochondrial (EC:6.1.1.21)
Alternative name(s):
Histidyl-tRNA synthetase
Short name:
HisRS
Gene namesi
Name:HARS2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3333MitochondrionSequence analysisAdd
BLAST
Chaini34 – 506473Probable histidine--tRNA ligase, mitochondrialPRO_0000341688Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei67 – 671PhosphoserineBy similarity
Modified residuei444 – 4441N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiA5D7V9.
PRIDEiA5D7V9.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035214.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1936. Eukaryota.
COG0124. LUCA.
HOGENOMiHOG000018075.
HOVERGENiHBG002731.
InParanoidiA5D7V9.
KOiK01892.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5D7V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPQLGLLPGR AWTVLLGLLR PPPGALCIRA VRSHSQVAEA LFASQLKPHQ
60 70 80 90 100
EKSNFTIKTP KGTRDLSPQQ MVVREKILDV VVSCFKRHGA KGLDTPAFEL
110 120 130 140 150
KEILTEKYGE DSGLIYDLKD QGGELLSLRY DLTVPFARYL AMNKVKKMKR
160 170 180 190 200
YHVGKVWRRE SPTIVQGRYR EFYQCDFDIA GQFDPMIPDA ECLKIMCEIL
210 220 230 240 250
SGLHLGDFLI KVSDRRILDG IFAVCGVPES KFHAICSSVD KLDKISWKDV
260 270 280 290 300
RHEMVVKKGL APEVADRIGD YVQCHGGISL VEQMFQDPRL SQNKQALEGL
310 320 330 340 350
GDLKLLFEYL TLFGVAEKVS FDLSLARGLD YYTGVIYEAV LLQTPVHAEE
360 370 380 390 400
EPLNMGSVAA GGRYDGLVGM FDPRGHKVPC VGLSIGVERI FSIVEQRIKT
410 420 430 440 450
FGEKIRTTET QVFVATPQKN FLQERLKLIA ELWDAGIKAE LMYKNNPKLL
460 470 480 490 500
PQLHYCENMG IPLVVIIGEQ ELKEGVIKLR SVASREEVAI KRENLVAEIQ

KRLSES
Length:506
Mass (Da):56,914
Last modified:June 12, 2007 - v1
Checksum:i3341230ACA738598
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140699 mRNA. Translation: AAI40700.1.
RefSeqiNP_001091602.1. NM_001098133.2.
UniGeneiBt.28199.

Genome annotation databases

GeneIDi615182.
KEGGibta:615182.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140699 mRNA. Translation: AAI40700.1.
RefSeqiNP_001091602.1. NM_001098133.2.
UniGeneiBt.28199.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000035214.

Proteomic databases

PaxDbiA5D7V9.
PRIDEiA5D7V9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi615182.
KEGGibta:615182.

Organism-specific databases

CTDi23438.

Phylogenomic databases

eggNOGiKOG1936. Eukaryota.
COG0124. LUCA.
HOGENOMiHOG000018075.
HOVERGENiHBG002731.
InParanoidiA5D7V9.
KOiK01892.

Miscellaneous databases

NextBioi20899487.

Family and domain databases

Gene3Di3.40.50.800. 1 hit.
InterProiIPR006195. aa-tRNA-synth_II.
IPR004154. Anticodon-bd.
IPR015807. His-tRNA-ligase.
IPR004516. HisRS/HisZ.
[Graphical view]
PANTHERiPTHR11476. PTHR11476. 1 hit.
PfamiPF03129. HGTP_anticodon. 1 hit.
[Graphical view]
PIRSFiPIRSF001549. His-tRNA_synth. 1 hit.
SUPFAMiSSF52954. SSF52954. 1 hit.
TIGRFAMsiTIGR00442. hisS. 1 hit.
PROSITEiPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiSYHM_BOVIN
AccessioniPrimary (citable) accession number: A5D7V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 12, 2007
Last modified: February 17, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.