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Protein

Tumor necrosis factor receptor superfamily member 11B

Gene

TNFRSF11B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei401Involved in dimerizationBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-BTA-5669034 TNFs bind their physiological receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11B
Alternative name(s):
Osteoprotegerin
Gene namesi
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Organism-specific databases

VGNCiVGNC:36161 TNFRSF11B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000039451222 – 402Tumor necrosis factor receptor superfamily member 11BAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 54PROSITE-ProRule annotation
Disulfide bondi44 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 80PROSITE-ProRule annotation
Disulfide bondi83 ↔ 97PROSITE-ProRule annotation
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation
Disulfide bondi124 ↔ 142PROSITE-ProRule annotation
Disulfide bondi145 ↔ 160PROSITE-ProRule annotation
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi166 ↔ 185PROSITE-ProRule annotation
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated. Contains sialic acid residues (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA5D7R1
PRIDEiA5D7R1

Expressioni

Gene expression databases

BgeeiENSBTAG00000007423

Interactioni

Subunit structurei

Homodimer. Interacts with TNFSF10 and TNFSF11 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009759

Structurei

3D structure databases

ProteinModelPortaliA5D7R1
SMRiA5D7R1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 62TNFR-Cys 1Add BLAST39
Repeati64 – 105TNFR-Cys 2Add BLAST42
Repeati106 – 142TNFR-Cys 3Add BLAST37
Repeati144 – 185TNFR-Cys 4Add BLAST42
Domaini198 – 269Death 1Add BLAST72
Domaini270 – 365Death 2Add BLAST96

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFEM Eukaryota
ENOG4111PUQ LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000273896
HOVERGENiHBG061495
InParanoidiA5D7R1
KOiK05148
OMAiSRQLMCD
OrthoDBiEOG091G03XW
TreeFamiTF331157

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022323 TNFR_11
IPR017371 TNFR_11B
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 3 hits
PIRSFiPIRSF038065 TNFR_11B, 1 hit
PRINTSiPR01961 TNFACTORR11
PR01975 TNFACTORR11B
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5D7R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLLCCALV FLDISIKWTT QETFPPKYLH YDPESSRQLM CDKCPPGTFL
60 70 80 90 100
KQPCTARRKT VCAPCPDHYY TDTWHTSDEC LYCSPVCKEL QYVKQECSRT
110 120 130 140 150
HNRVCECEEG RYLELEFCLK HRSCPPGFGV LHPGTPERNT VCKRCPDGFF
160 170 180 190 200
SNETSSKAPC RKHTNCSAFG LLLTQKGNAT HDNICSGSSE SSTHKCGIDM
210 220 230 240 250
TLCEEAFFRF AVPTKLTPNW LSVLVDNLPG TKVNAESIER IKQRHNSREQ
260 270 280 290 300
TFQLLKLWKH QNKDQDMVKK IIQDIDLCEN SVRRHIGHLN LTFEQLLKLM
310 320 330 340 350
ESLPGKKVTT EDVEKTVKTC KSSEQLLKLL SLWRIKNGDQ DTRKGLLHAL
360 370 380 390 400
KHLKTYHFPK TVIQSLKKTI RFLHSFTMYR LYRKLFLEMI GNQVQSLKIS

CL
Length:402
Mass (Da):46,418
Last modified:June 12, 2007 - v1
Checksum:iA0F6FDC15A355270
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140651 mRNA Translation: AAI40652.1
RefSeqiNP_001091525.1, NM_001098056.2
UniGeneiBt.40061

Genome annotation databases

EnsembliENSBTAT00000009759; ENSBTAP00000009759; ENSBTAG00000007423
GeneIDi523822
KEGGibta:523822

Similar proteinsi

Entry informationi

Entry nameiTR11B_BOVIN
AccessioniPrimary (citable) accession number: A5D7R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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