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Protein

Tumor necrosis factor receptor superfamily member 11B

Gene

TNFRSF11B

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei401Involved in dimerizationBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-BTA-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11B
Alternative name(s):
Osteoprotegerin
Gene namesi
Name:TNFRSF11B
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 14

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000039451222 – 402Tumor necrosis factor receptor superfamily member 11BAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 54PROSITE-ProRule annotation
Disulfide bondi44 ↔ 62PROSITE-ProRule annotation
Disulfide bondi65 ↔ 80PROSITE-ProRule annotation
Disulfide bondi83 ↔ 97PROSITE-ProRule annotation
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation
Disulfide bondi124 ↔ 142PROSITE-ProRule annotation
Disulfide bondi145 ↔ 160PROSITE-ProRule annotation
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi166 ↔ 185PROSITE-ProRule annotation
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated. Contains sialic acid residues (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA5D7R1.
PRIDEiA5D7R1.

Expressioni

Gene expression databases

BgeeiENSBTAG00000007423.

Interactioni

Subunit structurei

Homodimer. Interacts with TNFSF10 and TNFSF11 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009759.

Structurei

3D structure databases

ProteinModelPortaliA5D7R1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 62TNFR-Cys 1Add BLAST39
Repeati64 – 105TNFR-Cys 2Add BLAST42
Repeati106 – 142TNFR-Cys 3Add BLAST37
Repeati144 – 185TNFR-Cys 4Add BLAST42
Domaini198 – 269Death 1Add BLAST72
Domaini270 – 365Death 2Add BLAST96

Sequence similaritiesi

Contains 2 death domains.Curated
Contains 4 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFEM. Eukaryota.
ENOG4111PUQ. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000273896.
HOVERGENiHBG061495.
InParanoidiA5D7R1.
KOiK05148.
OMAiSRQLMCD.
OrthoDBiEOG091G03XW.
TreeFamiTF331157.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022323. TNFR_11.
IPR017371. TNFR_11B.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PIRSFiPIRSF038065. TNFR_11B. 1 hit.
PRINTSiPR01961. TNFACTORR11.
PR01975. TNFACTORR11B.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5D7R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLLCCALV FLDISIKWTT QETFPPKYLH YDPESSRQLM CDKCPPGTFL
60 70 80 90 100
KQPCTARRKT VCAPCPDHYY TDTWHTSDEC LYCSPVCKEL QYVKQECSRT
110 120 130 140 150
HNRVCECEEG RYLELEFCLK HRSCPPGFGV LHPGTPERNT VCKRCPDGFF
160 170 180 190 200
SNETSSKAPC RKHTNCSAFG LLLTQKGNAT HDNICSGSSE SSTHKCGIDM
210 220 230 240 250
TLCEEAFFRF AVPTKLTPNW LSVLVDNLPG TKVNAESIER IKQRHNSREQ
260 270 280 290 300
TFQLLKLWKH QNKDQDMVKK IIQDIDLCEN SVRRHIGHLN LTFEQLLKLM
310 320 330 340 350
ESLPGKKVTT EDVEKTVKTC KSSEQLLKLL SLWRIKNGDQ DTRKGLLHAL
360 370 380 390 400
KHLKTYHFPK TVIQSLKKTI RFLHSFTMYR LYRKLFLEMI GNQVQSLKIS

CL
Length:402
Mass (Da):46,418
Last modified:June 12, 2007 - v1
Checksum:iA0F6FDC15A355270
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140651 mRNA. Translation: AAI40652.1.
RefSeqiNP_001091525.1. NM_001098056.2.
UniGeneiBt.40061.

Genome annotation databases

EnsembliENSBTAT00000009759; ENSBTAP00000009759; ENSBTAG00000007423.
GeneIDi523822.
KEGGibta:523822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140651 mRNA. Translation: AAI40652.1.
RefSeqiNP_001091525.1. NM_001098056.2.
UniGeneiBt.40061.

3D structure databases

ProteinModelPortaliA5D7R1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009759.

Proteomic databases

PaxDbiA5D7R1.
PRIDEiA5D7R1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000009759; ENSBTAP00000009759; ENSBTAG00000007423.
GeneIDi523822.
KEGGibta:523822.

Organism-specific databases

CTDi4982.

Phylogenomic databases

eggNOGiENOG410IFEM. Eukaryota.
ENOG4111PUQ. LUCA.
GeneTreeiENSGT00760000119204.
HOGENOMiHOG000273896.
HOVERGENiHBG061495.
InParanoidiA5D7R1.
KOiK05148.
OMAiSRQLMCD.
OrthoDBiEOG091G03XW.
TreeFamiTF331157.

Enzyme and pathway databases

ReactomeiR-BTA-5669034. TNFs bind their physiological receptors.

Gene expression databases

BgeeiENSBTAG00000007423.

Family and domain databases

Gene3Di1.10.533.10. 2 hits.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022323. TNFR_11.
IPR017371. TNFR_11B.
IPR011641. Tyr-kin_ephrin_A/B_rcpt-like.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PIRSFiPIRSF038065. TNFR_11B. 1 hit.
PRINTSiPR01961. TNFACTORR11.
PR01975. TNFACTORR11B.
SMARTiSM00005. DEATH. 1 hit.
SM01411. Ephrin_rec_like. 2 hits.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 2 hits.
PROSITEiPS00652. TNFR_NGFR_1. 1 hit.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTR11B_BOVIN
AccessioniPrimary (citable) accession number: A5D7R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 12, 2007
Last modified: November 30, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.