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Protein

Transmembrane protein 88

Gene

TMEM88

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits the Wnt/beta-catenin signaling pathway. Crucial for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify lineage commitment of cardiomyocyte development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 88
Gene namesi
Name:TMEM88
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:36120 TMEM88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003464481 – 159Transmembrane protein 88Add BLAST159

Proteomic databases

PaxDbiA5D7M7

Expressioni

Gene expression databases

BgeeiENSBTAG00000014693

Interactioni

Subunit structurei

Interacts (via C-terminus) with DVL1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000019555

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM88 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZIZ Eukaryota
ENOG41121G3 LUCA
GeneTreeiENSGT00510000047877
HOGENOMiHOG000118356
HOVERGENiHBG095158
InParanoidiA5D7M7
OMAiMCFIPYS
OrthoDBiEOG091G11O8
TreeFamiTF332743

Family and domain databases

InterProiView protein in InterPro
IPR033355 TMEM88
IPR033354 TMEM88A
PANTHERiPTHR28628 PTHR28628, 1 hit
PTHR28628:SF3 PTHR28628:SF3, 1 hit

Sequencei

Sequence statusi: Complete.

A5D7M7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADVPGAQRP VPGGGPEPRD PLDCWACAVL VTAQNLLVAA FNLLLLALVL
60 70 80 90 100
GTILLPAVTM LGFGFLCHSQ FLRSQAPPCT AHLRDPGFTA LLVTGFLLLV
110 120 130 140 150
PLLVLALASY RRLCLRLRLA DCLVPYSRAL YRRRRNPQPR PARSSPGPQV

APTSGKVWV
Length:159
Mass (Da):17,187
Last modified:June 12, 2007 - v1
Checksum:iCBEA842FC69220BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140617 mRNA Translation: AAI40618.1
RefSeqiNP_001091848.1, NM_001098378.2
UniGeneiBt.92178

Genome annotation databases

EnsembliENSBTAT00000019555; ENSBTAP00000019555; ENSBTAG00000014693
GeneIDi507172
KEGGibta:507172

Similar proteinsi

Entry informationi

Entry nameiTMM88_BOVIN
AccessioniPrimary (citable) accession number: A5D7M7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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