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Protein

Prostaglandin D2 receptor

Gene

PTGDR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-391908. Prostanoid ligand receptors.
R-BTA-418555. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:PTGDR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121ExtracellularSequence analysisAdd
BLAST
Transmembranei22 – 4221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini43 – 5816CytoplasmicSequence analysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10728ExtracellularSequence analysisAdd
BLAST
Transmembranei108 – 12821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini129 – 15022CytoplasmicSequence analysisAdd
BLAST
Transmembranei151 – 17121Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini172 – 19524ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 26246CytoplasmicSequence analysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini284 – 31027ExtracellularSequence analysisAdd
BLAST
Transmembranei311 – 33121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini332 – 36130CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Prostaglandin D2 receptorPRO_0000370710Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi90 – 901N-linked (GlcNAc...)Sequence analysis
Disulfide bondi105 ↔ 183PROSITE-ProRule annotation
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA5D7K8.

Expressioni

Gene expression databases

BgeeiENSBTAG00000006703.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008808.

Structurei

3D structure databases

ProteinModelPortaliA5D7K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
InParanoidiA5D7K8.
KOiK04332.
OMAiSLCQAFA.
OrthoDBiEOG091G0F07.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5D7K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLFYRCHN TTSVEKGNSA TMGGVLFSTG LVGNLLALGL LARSGLGSCP
60 70 80 90 100
PRSPRPPPSV FYVLVFGLTI TDLLGKCLVS PFVLSAYAQN RSLRELVPGS
110 120 130 140 150
DSSLCQAFAF IMSFFGLAST LQLLAMALEC WLSLGHPFFH RRHLTPRRGA
160 170 180 190 200
MVAPVVGAFC LAFCALPLVG FGKFVQYCPG TWCFFQMVHE ERSLSVLSYS
210 220 230 240 250
VLYASLMLLL VLAIVLCNLS AMRNLYAMHL RLRGLLRPGS RERAEPGAGE
260 270 280 290 300
REATPLHLEE LDHLLLLALM TVLFTMCSLP LIYRAYYGAF KAVPEQNGTT
310 320 330 340 350
EETEDLRALR FLSVISIVDP WIFIIFRTSV FRMFFRKIFI RPLIYRNWHS
360
NSCQTNMESS L
Length:361
Mass (Da):40,372
Last modified:June 12, 2007 - v1
Checksum:iDF0C341605C1CAD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140594 mRNA. Translation: AAI40595.1.
RefSeqiNP_001091503.1. NM_001098034.1.
UniGeneiBt.86353.

Genome annotation databases

EnsembliENSBTAT00000008808; ENSBTAP00000008808; ENSBTAG00000006703.
GeneIDi515331.
KEGGibta:515331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140594 mRNA. Translation: AAI40595.1.
RefSeqiNP_001091503.1. NM_001098034.1.
UniGeneiBt.86353.

3D structure databases

ProteinModelPortaliA5D7K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008808.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiA5D7K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008808; ENSBTAP00000008808; ENSBTAG00000006703.
GeneIDi515331.
KEGGibta:515331.

Organism-specific databases

CTDi5729.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
InParanoidiA5D7K8.
KOiK04332.
OMAiSLCQAFA.
OrthoDBiEOG091G0F07.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiR-BTA-391908. Prostanoid ligand receptors.
R-BTA-418555. G alpha (s) signalling events.

Gene expression databases

BgeeiENSBTAG00000006703.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPD2R_BOVIN
AccessioniPrimary (citable) accession number: A5D7K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 12, 2007
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.