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Protein

Prostaglandin D2 receptor

Gene

PTGDR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-BTA-391908 Prostanoid ligand receptors
R-BTA-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:PTGDR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 10

Organism-specific databases

VGNCiVGNC:33499 PTGDR

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 58CytoplasmicSequence analysisAdd BLAST16
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 107ExtracellularSequence analysisAdd BLAST28
Transmembranei108 – 128Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini129 – 150CytoplasmicSequence analysisAdd BLAST22
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 195ExtracellularSequence analysisAdd BLAST24
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 262CytoplasmicSequence analysisAdd BLAST46
Transmembranei263 – 283Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini284 – 310ExtracellularSequence analysisAdd BLAST27
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 361CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003707101 – 361Prostaglandin D2 receptorAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi105 ↔ 183PROSITE-ProRule annotation
Glycosylationi297N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA5D7K8

Expressioni

Gene expression databases

BgeeiENSBTAG00000006703

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008808

Structurei

3D structure databases

ProteinModelPortaliA5D7K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000115475
InParanoidiA5D7K8
KOiK04332
OMAiSLCQAFA
OrthoDBiEOG091G0F07
TreeFamiTF324982

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000376 Pglndn_D_rcpt
IPR008365 Prostanoid_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF14 PTHR11866:SF14, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01788 PROSTANOIDR
PR00854 PRSTNOIDDPR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5D7K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLFYRCHN TTSVEKGNSA TMGGVLFSTG LVGNLLALGL LARSGLGSCP
60 70 80 90 100
PRSPRPPPSV FYVLVFGLTI TDLLGKCLVS PFVLSAYAQN RSLRELVPGS
110 120 130 140 150
DSSLCQAFAF IMSFFGLAST LQLLAMALEC WLSLGHPFFH RRHLTPRRGA
160 170 180 190 200
MVAPVVGAFC LAFCALPLVG FGKFVQYCPG TWCFFQMVHE ERSLSVLSYS
210 220 230 240 250
VLYASLMLLL VLAIVLCNLS AMRNLYAMHL RLRGLLRPGS RERAEPGAGE
260 270 280 290 300
REATPLHLEE LDHLLLLALM TVLFTMCSLP LIYRAYYGAF KAVPEQNGTT
310 320 330 340 350
EETEDLRALR FLSVISIVDP WIFIIFRTSV FRMFFRKIFI RPLIYRNWHS
360
NSCQTNMESS L
Length:361
Mass (Da):40,372
Last modified:June 12, 2007 - v1
Checksum:iDF0C341605C1CAD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140594 mRNA Translation: AAI40595.1
RefSeqiNP_001091503.1, NM_001098034.1
UniGeneiBt.86353

Genome annotation databases

EnsembliENSBTAT00000008808; ENSBTAP00000008808; ENSBTAG00000006703
GeneIDi515331
KEGGibta:515331

Similar proteinsi

Entry informationi

Entry nameiPD2R_BOVIN
AccessioniPrimary (citable) accession number: A5D7K8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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