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Protein

Nuclear factor erythroid 2-related factor 1

Gene

NFE2L1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Activates erythroid-specific, globin gene expression.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor erythroid 2-related factor 1
Short name:
NF-E2-related factor 1
Short name:
NFE2-related factor 1
Alternative name(s):
Nuclear factor, erythroid derived 2, like 1
Gene namesi
Name:NFE2L1
Synonyms:NRF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2418Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 763763Nuclear factor erythroid 2-related factor 1PRO_0000341946Add
BLAST

Proteomic databases

PaxDbiA5D7E9.

Interactioni

Subunit structurei

Interacts with KEAP1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018147.

Structurei

3D structure databases

ProteinModelPortaliA5D7E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini645 – 70864bZIPPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni647 – 66620Basic motifPROSITE-ProRule annotationAdd
BLAST
Regioni673 – 68715Leucine-zipperPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi752 – 7598Nuclear localization signalSequence analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi465 – 52157Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the bZIP family. CNC subfamily.Curated
Contains 1 bZIP (basic-leucine zipper) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3863. Eukaryota.
ENOG410ZGMS. LUCA.
GeneTreeiENSGT00830000128250.
HOVERGENiHBG052609.
InParanoidiA5D7E9.
KOiK09040.
OMAiHKHSGPS.
OrthoDBiEOG715Q3N.
TreeFamiTF326681.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR029847. Nrf1.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR24411:SF31. PTHR24411:SF31. 3 hits.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5D7E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLKKYLTE GLLQFTILLS LIGVRVDVDT YLTSQLPPLR EIILGPSSAY
60 70 80 90 100
TQTQFHNLRN TLDGYGIHPK SIDLDNYFTA RRLLNQVRAL DRFQVPTTEV
110 120 130 140 150
NAWLVHRDPE GSVSGSQPSS GLALESSSGL QDVTGPDNGV RESETEQGFS
160 170 180 190 200
EDLEDLGAVA PPVSGDLTKE DIDLGAGREI FDYSHRQKEQ DVDKELRDGA
210 220 230 240 250
EQEDTWPGEG AEALARNLLV DGETGESFPA QVPGGEDQTA LSLEECLRLL
260 270 280 290 300
EATCPFGENA EFPADISSIT EAVPSESEPP GLQNNLLSPL LTGTESPFDL
310 320 330 340 350
EQQWQDLMSI MEMQAMEVNT STSEVLYNAP PGDPLSTNYS LAPNTPINQN
360 370 380 390 400
VSLHQASLGG CSQDFSLFSP EVESLPVASS STLLPLVPSN STSLNSTFGS
410 420 430 440 450
TNLAGLFFPP QLNGTANDTA GPELPDPLGG LLDEAMLDEI SLMDLAIEEG
460 470 480 490 500
FNPVQASQLE EEFDSDSGLS LDSSHSPSSL SSSEGSSSSS SSSSSSSSSS
510 520 530 540 550
ASSSASSSFS EEGAVGYSSD SETLDLEEAE GAVGYQPEYS KFCRMSYQDP
560 570 580 590 600
SQLSCLPYLE HVGHNHTYNM APSALDSADL PPPSTLKKGS KEKQADFLDK
610 620 630 640 650
QMSRDEHRAR AMKIPFTNDK IINLPVEEFN ELLSKYQLSE AQLSLIRDIR
660 670 680 690 700
RRGKNKMAAQ NCRKRKLDTI LNLERDVEDL QRDKARLLRE KVEFLRSLRQ
710 720 730 740 750
MKQKVQSLYQ EVFGRLRDEN GRPYSPSQYA LQYAGDGSVL LIPRTLADQQ
760
ARRQERKPKD RRK
Length:763
Mass (Da):83,607
Last modified:June 12, 2007 - v1
Checksum:i3C78D811BE63A378
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140530 mRNA. Translation: AAI40531.1.
RefSeqiNP_001095985.1. NM_001102515.1.
XP_005220649.1. XM_005220592.3.
UniGeneiBt.28567.

Genome annotation databases

EnsembliENSBTAT00000018147; ENSBTAP00000018147; ENSBTAG00000013653.
GeneIDi534582.
KEGGibta:534582.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC140530 mRNA. Translation: AAI40531.1.
RefSeqiNP_001095985.1. NM_001102515.1.
XP_005220649.1. XM_005220592.3.
UniGeneiBt.28567.

3D structure databases

ProteinModelPortaliA5D7E9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000018147.

Proteomic databases

PaxDbiA5D7E9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000018147; ENSBTAP00000018147; ENSBTAG00000013653.
GeneIDi534582.
KEGGibta:534582.

Organism-specific databases

CTDi4779.

Phylogenomic databases

eggNOGiKOG3863. Eukaryota.
ENOG410ZGMS. LUCA.
GeneTreeiENSGT00830000128250.
HOVERGENiHBG052609.
InParanoidiA5D7E9.
KOiK09040.
OMAiHKHSGPS.
OrthoDBiEOG715Q3N.
TreeFamiTF326681.

Miscellaneous databases

NextBioi20876454.

Family and domain databases

Gene3Di1.10.880.10. 1 hit.
InterProiIPR004827. bZIP.
IPR004826. bZIP_Maf.
IPR029847. Nrf1.
IPR008917. TF_DNA-bd.
[Graphical view]
PANTHERiPTHR24411:SF31. PTHR24411:SF31. 3 hits.
PfamiPF03131. bZIP_Maf. 1 hit.
[Graphical view]
SMARTiSM00338. BRLZ. 1 hit.
[Graphical view]
SUPFAMiSSF47454. SSF47454. 1 hit.
PROSITEiPS50217. BZIP. 1 hit.
PS00036. BZIP_BASIC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiNF2L1_BOVIN
AccessioniPrimary (citable) accession number: A5D7E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: June 12, 2007
Last modified: April 13, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.