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A5D6W6

- FITM1_HUMAN

UniProt

A5D6W6 - FITM1_HUMAN

Protein

Fat storage-inducing transmembrane protein 1

Gene

FITM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Plays an important role in lipid droplet accumulation.1 Publication

    GO - Biological processi

    1. lipid particle organization Source: BHF-UCL
    2. positive regulation of sequestering of triglyceride Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fat storage-inducing transmembrane protein 1
    Alternative name(s):
    Fat-inducing protein 1
    Gene namesi
    Name:FITM1
    Synonyms:FIT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:33714. FITM1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: BHF-UCL
    2. integral component of endoplasmic reticulum membrane Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165478932.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Fat storage-inducing transmembrane protein 1PRO_0000319575Add
    BLAST

    Proteomic databases

    PaxDbiA5D6W6.
    PeptideAtlasiA5D6W6.
    PRIDEiA5D6W6.

    PTM databases

    PhosphoSiteiA5D6W6.

    Expressioni

    Tissue specificityi

    Primarily expressed in heart and skeletal muscle.1 Publication

    Gene expression databases

    BgeeiA5D6W6.
    GenevestigatoriA5D6W6.

    Organism-specific databases

    HPAiHPA019842.

    Interactioni

    Protein-protein interaction databases

    BioGridi127777. 1 interaction.
    STRINGi9606.ENSP00000267426.

    Structurei

    3D structure databases

    ProteinModelPortaliA5D6W6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini40 – 5415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini76 – 9419CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini116 – 18772ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini209 – 22012CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini242 – 2498ExtracellularSequence Analysis
    Topological domaini271 – 29222CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei19 – 3921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei188 – 20821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei221 – 24121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei250 – 27021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FIT family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG133996.
    HOGENOMiHOG000112594.
    InParanoidiA5D6W6.
    OMAiALGCLSW.
    OrthoDBiEOG78D7KT.
    PhylomeDBiA5D6W6.

    Family and domain databases

    InterProiIPR019388. FIT.
    [Graphical view]
    PfamiPF10261. Scs3p. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A5D6W6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MERGPVVGAG LGAGARIQAL LGCLLKVLLW VASALLYFGS EQAARLLGSP    50
    CLRRLYHAWL AAVVIFGPLL QFHVNPRTIF ASHGNFFNIK FVNSAWGWTC 100
    TFLGGFVLLV VFLATRRVAV TARHLSRLVV GAAVWRGAGR AFLLIEDLTG 150
    SCFEPLPQGL LLHELPDRRS CLAAGHQWRG YTVSSHTFLL TFCCLLMAEE 200
    AAVFAKYLAH GLPAGAPLRL VFLLNVLLLG LWNFLLLCTV IYFHQYTHKV 250
    VGAAVGTFAW YLTYGSWYHQ PWSPGSPGHG LFPRPHSSRK HN 292
    Length:292
    Mass (Da):32,207
    Last modified:June 12, 2007 - v1
    Checksum:i5722083EB85EEDC8
    GO
    Isoform 2 (identifier: A5D6W6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-196: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:96
    Mass (Da):10,778
    Checksum:iF8250E362DE96701
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 196196Missing in isoform 2. 1 PublicationVSP_031493Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471078 Genomic DNA. Translation: EAW66107.1.
    BC042179 mRNA. No translation available.
    BC139911 mRNA. Translation: AAI39912.1.
    CCDSiCCDS9611.1. [A5D6W6-1]
    RefSeqiNP_981947.1. NM_203402.2. [A5D6W6-1]
    UniGeneiHs.128060.

    Genome annotation databases

    EnsembliENST00000267426; ENSP00000267426; ENSG00000139914. [A5D6W6-1]
    ENST00000559294; ENSP00000453741; ENSG00000139914. [A5D6W6-2]
    GeneIDi161247.
    KEGGihsa:161247.
    UCSCiuc001wmf.2. human. [A5D6W6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471078 Genomic DNA. Translation: EAW66107.1 .
    BC042179 mRNA. No translation available.
    BC139911 mRNA. Translation: AAI39912.1 .
    CCDSi CCDS9611.1. [A5D6W6-1 ]
    RefSeqi NP_981947.1. NM_203402.2. [A5D6W6-1 ]
    UniGenei Hs.128060.

    3D structure databases

    ProteinModelPortali A5D6W6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127777. 1 interaction.
    STRINGi 9606.ENSP00000267426.

    PTM databases

    PhosphoSitei A5D6W6.

    Proteomic databases

    PaxDbi A5D6W6.
    PeptideAtlasi A5D6W6.
    PRIDEi A5D6W6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000267426 ; ENSP00000267426 ; ENSG00000139914 . [A5D6W6-1 ]
    ENST00000559294 ; ENSP00000453741 ; ENSG00000139914 . [A5D6W6-2 ]
    GeneIDi 161247.
    KEGGi hsa:161247.
    UCSCi uc001wmf.2. human. [A5D6W6-1 ]

    Organism-specific databases

    CTDi 161247.
    GeneCardsi GC14P024600.
    HGNCi HGNC:33714. FITM1.
    HPAi HPA019842.
    MIMi 612028. gene.
    neXtProti NX_A5D6W6.
    PharmGKBi PA165478932.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG133996.
    HOGENOMi HOG000112594.
    InParanoidi A5D6W6.
    OMAi ALGCLSW.
    OrthoDBi EOG78D7KT.
    PhylomeDBi A5D6W6.

    Miscellaneous databases

    GenomeRNAii 161247.
    NextBioi 88037.
    PROi A5D6W6.
    SOURCEi Search...

    Gene expression databases

    Bgeei A5D6W6.
    Genevestigatori A5D6W6.

    Family and domain databases

    InterProi IPR019388. FIT.
    [Graphical view ]
    Pfami PF10261. Scs3p. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Pancreas.
    3. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiFITM1_HUMAN
    AccessioniPrimary (citable) accession number: A5D6W6
    Secondary accession number(s): Q8IUQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families
    4. Uncharacterized protein families (UPF)
      List of uncharacterized protein family (UPF) entries

    External Data

    Dasty 3