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Protein

Fat storage-inducing transmembrane protein 1

Gene

FITM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays an important role in lipid droplet accumulation.1 Publication

GO - Biological processi

  • lipid particle organization Source: BHF-UCL
  • lipid storage Source: GO_Central
  • phospholipid biosynthetic process Source: GO_Central
  • positive regulation of sequestering of triglyceride Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Fat storage-inducing transmembrane protein 1
Alternative name(s):
Fat-inducing protein 1
Gene namesi
Name:FITM1
Synonyms:FIT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:33714. FITM1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Topological domaini40 – 5415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Topological domaini76 – 9419CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence AnalysisAdd
BLAST
Topological domaini116 – 18772ExtracellularSequence AnalysisAdd
BLAST
Transmembranei188 – 20821HelicalSequence AnalysisAdd
BLAST
Topological domaini209 – 22012CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei221 – 24121HelicalSequence AnalysisAdd
BLAST
Topological domaini242 – 2498ExtracellularSequence Analysis
Transmembranei250 – 27021HelicalSequence AnalysisAdd
BLAST
Topological domaini271 – 29222CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum membrane Source: BHF-UCL
  • integral component of endoplasmic reticulum membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165478932.

Polymorphism and mutation databases

BioMutaiFITM1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Fat storage-inducing transmembrane protein 1PRO_0000319575Add
BLAST

Proteomic databases

PaxDbiA5D6W6.
PeptideAtlasiA5D6W6.
PRIDEiA5D6W6.

PTM databases

PhosphoSiteiA5D6W6.

Expressioni

Tissue specificityi

Primarily expressed in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiA5D6W6.
GenevestigatoriA5D6W6.

Organism-specific databases

HPAiHPA019842.

Interactioni

Protein-protein interaction databases

BioGridi127777. 1 interaction.
STRINGi9606.ENSP00000267426.

Structurei

3D structure databases

ProteinModelPortaliA5D6W6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FIT family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG133996.
GeneTreeiENSGT00530000063693.
HOGENOMiHOG000112594.
InParanoidiA5D6W6.
OMAiSGWGWTC.
OrthoDBiEOG78D7KT.
PhylomeDBiA5D6W6.

Family and domain databases

InterProiIPR019388. FIT.
[Graphical view]
PfamiPF10261. Scs3p. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A5D6W6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERGPVVGAG LGAGARIQAL LGCLLKVLLW VASALLYFGS EQAARLLGSP
60 70 80 90 100
CLRRLYHAWL AAVVIFGPLL QFHVNPRTIF ASHGNFFNIK FVNSAWGWTC
110 120 130 140 150
TFLGGFVLLV VFLATRRVAV TARHLSRLVV GAAVWRGAGR AFLLIEDLTG
160 170 180 190 200
SCFEPLPQGL LLHELPDRRS CLAAGHQWRG YTVSSHTFLL TFCCLLMAEE
210 220 230 240 250
AAVFAKYLAH GLPAGAPLRL VFLLNVLLLG LWNFLLLCTV IYFHQYTHKV
260 270 280 290
VGAAVGTFAW YLTYGSWYHQ PWSPGSPGHG LFPRPHSSRK HN
Length:292
Mass (Da):32,207
Last modified:June 12, 2007 - v1
Checksum:i5722083EB85EEDC8
GO
Isoform 2 (identifier: A5D6W6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Note: No experimental confirmation available.

Show »
Length:96
Mass (Da):10,778
Checksum:iF8250E362DE96701
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 196196Missing in isoform 2. 1 PublicationVSP_031493Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471078 Genomic DNA. Translation: EAW66107.1.
BC042179 mRNA. No translation available.
BC139911 mRNA. Translation: AAI39912.1.
CCDSiCCDS9611.1. [A5D6W6-1]
RefSeqiNP_981947.1. NM_203402.2. [A5D6W6-1]
UniGeneiHs.128060.

Genome annotation databases

EnsembliENST00000267426; ENSP00000267426; ENSG00000139914. [A5D6W6-1]
ENST00000559294; ENSP00000453741; ENSG00000139914. [A5D6W6-2]
GeneIDi161247.
KEGGihsa:161247.
UCSCiuc001wmf.2. human. [A5D6W6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471078 Genomic DNA. Translation: EAW66107.1.
BC042179 mRNA. No translation available.
BC139911 mRNA. Translation: AAI39912.1.
CCDSiCCDS9611.1. [A5D6W6-1]
RefSeqiNP_981947.1. NM_203402.2. [A5D6W6-1]
UniGeneiHs.128060.

3D structure databases

ProteinModelPortaliA5D6W6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127777. 1 interaction.
STRINGi9606.ENSP00000267426.

PTM databases

PhosphoSiteiA5D6W6.

Polymorphism and mutation databases

BioMutaiFITM1.

Proteomic databases

PaxDbiA5D6W6.
PeptideAtlasiA5D6W6.
PRIDEiA5D6W6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267426; ENSP00000267426; ENSG00000139914. [A5D6W6-1]
ENST00000559294; ENSP00000453741; ENSG00000139914. [A5D6W6-2]
GeneIDi161247.
KEGGihsa:161247.
UCSCiuc001wmf.2. human. [A5D6W6-1]

Organism-specific databases

CTDi161247.
GeneCardsiGC14P024600.
HGNCiHGNC:33714. FITM1.
HPAiHPA019842.
MIMi612028. gene.
neXtProtiNX_A5D6W6.
PharmGKBiPA165478932.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG133996.
GeneTreeiENSGT00530000063693.
HOGENOMiHOG000112594.
InParanoidiA5D6W6.
OMAiSGWGWTC.
OrthoDBiEOG78D7KT.
PhylomeDBiA5D6W6.

Miscellaneous databases

GenomeRNAii161247.
NextBioi88037.
PROiA5D6W6.
SOURCEiSearch...

Gene expression databases

BgeeiA5D6W6.
GenevestigatoriA5D6W6.

Family and domain databases

InterProiIPR019388. FIT.
[Graphical view]
PfamiPF10261. Scs3p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas.
  3. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFITM1_HUMAN
AccessioniPrimary (citable) accession number: A5D6W6
Secondary accession number(s): Q8IUQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: April 29, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.