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A5D6W6

- FITM1_HUMAN

UniProt

A5D6W6 - FITM1_HUMAN

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Protein
Fat storage-inducing transmembrane protein 1
Gene
FITM1, FIT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Plays an important role in lipid droplet accumulation.1 Publication

GO - Biological processi

  1. lipid particle organization Source: BHF-UCL
  2. positive regulation of sequestering of triglyceride Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Fat storage-inducing transmembrane protein 1
Alternative name(s):
Fat-inducing protein 1
Gene namesi
Name:FITM1
Synonyms:FIT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:33714. FITM1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei19 – 3921Helical; Reviewed prediction
Add
BLAST
Topological domaini40 – 5415Extracellular Reviewed prediction
Add
BLAST
Transmembranei55 – 7521Helical; Reviewed prediction
Add
BLAST
Topological domaini76 – 9419Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei95 – 11521Helical; Reviewed prediction
Add
BLAST
Topological domaini116 – 18772Extracellular Reviewed prediction
Add
BLAST
Transmembranei188 – 20821Helical; Reviewed prediction
Add
BLAST
Topological domaini209 – 22012Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei221 – 24121Helical; Reviewed prediction
Add
BLAST
Topological domaini242 – 2498Extracellular Reviewed prediction
Transmembranei250 – 27021Helical; Reviewed prediction
Add
BLAST
Topological domaini271 – 29222Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: BHF-UCL
  2. integral component of endoplasmic reticulum membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165478932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Fat storage-inducing transmembrane protein 1
PRO_0000319575Add
BLAST

Proteomic databases

PaxDbiA5D6W6.
PeptideAtlasiA5D6W6.
PRIDEiA5D6W6.

PTM databases

PhosphoSiteiA5D6W6.

Expressioni

Tissue specificityi

Primarily expressed in heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiA5D6W6.
GenevestigatoriA5D6W6.

Organism-specific databases

HPAiHPA019842.

Interactioni

Protein-protein interaction databases

BioGridi127777. 1 interaction.
STRINGi9606.ENSP00000267426.

Structurei

3D structure databases

ProteinModelPortaliA5D6W6.

Family & Domainsi

Sequence similaritiesi

Belongs to the FIT family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG133996.
HOGENOMiHOG000112594.
InParanoidiA5D6W6.
OMAiALGCLSW.
OrthoDBiEOG78D7KT.
PhylomeDBiA5D6W6.

Family and domain databases

InterProiIPR019388. FIT.
[Graphical view]
PfamiPF10261. Scs3p. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A5D6W6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MERGPVVGAG LGAGARIQAL LGCLLKVLLW VASALLYFGS EQAARLLGSP    50
CLRRLYHAWL AAVVIFGPLL QFHVNPRTIF ASHGNFFNIK FVNSAWGWTC 100
TFLGGFVLLV VFLATRRVAV TARHLSRLVV GAAVWRGAGR AFLLIEDLTG 150
SCFEPLPQGL LLHELPDRRS CLAAGHQWRG YTVSSHTFLL TFCCLLMAEE 200
AAVFAKYLAH GLPAGAPLRL VFLLNVLLLG LWNFLLLCTV IYFHQYTHKV 250
VGAAVGTFAW YLTYGSWYHQ PWSPGSPGHG LFPRPHSSRK HN 292
Length:292
Mass (Da):32,207
Last modified:June 12, 2007 - v1
Checksum:i5722083EB85EEDC8
GO
Isoform 2 (identifier: A5D6W6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.

Note: No experimental confirmation available.

Show »
Length:96
Mass (Da):10,778
Checksum:iF8250E362DE96701
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 196196Missing in isoform 2.
VSP_031493Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471078 Genomic DNA. Translation: EAW66107.1.
BC042179 mRNA. No translation available.
BC139911 mRNA. Translation: AAI39912.1.
CCDSiCCDS9611.1. [A5D6W6-1]
RefSeqiNP_981947.1. NM_203402.2. [A5D6W6-1]
UniGeneiHs.128060.

Genome annotation databases

EnsembliENST00000267426; ENSP00000267426; ENSG00000139914. [A5D6W6-1]
ENST00000559294; ENSP00000453741; ENSG00000139914. [A5D6W6-2]
GeneIDi161247.
KEGGihsa:161247.
UCSCiuc001wmf.2. human. [A5D6W6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471078 Genomic DNA. Translation: EAW66107.1 .
BC042179 mRNA. No translation available.
BC139911 mRNA. Translation: AAI39912.1 .
CCDSi CCDS9611.1. [A5D6W6-1 ]
RefSeqi NP_981947.1. NM_203402.2. [A5D6W6-1 ]
UniGenei Hs.128060.

3D structure databases

ProteinModelPortali A5D6W6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127777. 1 interaction.
STRINGi 9606.ENSP00000267426.

PTM databases

PhosphoSitei A5D6W6.

Proteomic databases

PaxDbi A5D6W6.
PeptideAtlasi A5D6W6.
PRIDEi A5D6W6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000267426 ; ENSP00000267426 ; ENSG00000139914 . [A5D6W6-1 ]
ENST00000559294 ; ENSP00000453741 ; ENSG00000139914 . [A5D6W6-2 ]
GeneIDi 161247.
KEGGi hsa:161247.
UCSCi uc001wmf.2. human. [A5D6W6-1 ]

Organism-specific databases

CTDi 161247.
GeneCardsi GC14P024600.
HGNCi HGNC:33714. FITM1.
HPAi HPA019842.
MIMi 612028. gene.
neXtProti NX_A5D6W6.
PharmGKBi PA165478932.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG133996.
HOGENOMi HOG000112594.
InParanoidi A5D6W6.
OMAi ALGCLSW.
OrthoDBi EOG78D7KT.
PhylomeDBi A5D6W6.

Miscellaneous databases

GenomeRNAii 161247.
NextBioi 88037.
PROi A5D6W6.
SOURCEi Search...

Gene expression databases

Bgeei A5D6W6.
Genevestigatori A5D6W6.

Family and domain databases

InterProi IPR019388. FIT.
[Graphical view ]
Pfami PF10261. Scs3p. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas.
  3. Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiFITM1_HUMAN
AccessioniPrimary (citable) accession number: A5D6W6
Secondary accession number(s): Q8IUQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: July 9, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

External Data

Dasty 3

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