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A5D6W6 (FITM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fat storage-inducing transmembrane protein 1
Alternative name(s):
Fat-inducing protein 1
Gene names
Name:FITM1
Synonyms:FIT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in lipid droplet accumulation. Ref.3

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein Ref.3.

Tissue specificity

Primarily expressed in heart and skeletal muscle. Ref.3

Sequence similarities

Belongs to the FIT family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A5D6W6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A5D6W6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-196: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Fat storage-inducing transmembrane protein 1
PRO_0000319575

Regions

Topological domain1 – 1818Cytoplasmic Potential
Transmembrane19 – 3921Helical; Potential
Topological domain40 – 5415Extracellular Potential
Transmembrane55 – 7521Helical; Potential
Topological domain76 – 9419Cytoplasmic Potential
Transmembrane95 – 11521Helical; Potential
Topological domain116 – 18772Extracellular Potential
Transmembrane188 – 20821Helical; Potential
Topological domain209 – 22012Cytoplasmic Potential
Transmembrane221 – 24121Helical; Potential
Topological domain242 – 2498Extracellular Potential
Transmembrane250 – 27021Helical; Potential
Topological domain271 – 29222Cytoplasmic Potential

Natural variations

Alternative sequence1 – 196196Missing in isoform 2.
VSP_031493

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 5722083EB85EEDC8

FASTA29232,207
        10         20         30         40         50         60 
MERGPVVGAG LGAGARIQAL LGCLLKVLLW VASALLYFGS EQAARLLGSP CLRRLYHAWL 

        70         80         90        100        110        120 
AAVVIFGPLL QFHVNPRTIF ASHGNFFNIK FVNSAWGWTC TFLGGFVLLV VFLATRRVAV 

       130        140        150        160        170        180 
TARHLSRLVV GAAVWRGAGR AFLLIEDLTG SCFEPLPQGL LLHELPDRRS CLAAGHQWRG 

       190        200        210        220        230        240 
YTVSSHTFLL TFCCLLMAEE AAVFAKYLAH GLPAGAPLRL VFLLNVLLLG LWNFLLLCTV 

       250        260        270        280        290 
IYFHQYTHKV VGAAVGTFAW YLTYGSWYHQ PWSPGSPGHG LFPRPHSSRK HN 

« Hide

Isoform 2 [UniParc].

Checksum: F8250E362DE96701
Show »

FASTA9610,778

References

« Hide 'large scale' references
[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Pancreas.
[3]"Evolutionarily conserved gene family important for fat storage."
Kadereit B., Kumar P., Wang W.-J., Miranda D., Snapp E.L., Severina N., Torregroza I., Evans T., Silver D.L.
Proc. Natl. Acad. Sci. U.S.A. 105:94-99(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471078 Genomic DNA. Translation: EAW66107.1.
BC042179 mRNA. No translation available.
BC139911 mRNA. Translation: AAI39912.1.
RefSeqNP_981947.1. NM_203402.2.
UniGeneHs.128060.

3D structure databases

ProteinModelPortalA5D6W6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127777. 1 interaction.
STRING9606.ENSP00000267426.

PTM databases

PhosphoSiteA5D6W6.

Proteomic databases

PaxDbA5D6W6.
PeptideAtlasA5D6W6.
PRIDEA5D6W6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267426; ENSP00000267426; ENSG00000139914. [A5D6W6-1]
ENST00000559294; ENSP00000453741; ENSG00000139914. [A5D6W6-2]
GeneID161247.
KEGGhsa:161247.
UCSCuc001wmf.2. human. [A5D6W6-1]

Organism-specific databases

CTD161247.
GeneCardsGC14P024600.
HGNCHGNC:33714. FITM1.
HPAHPA019842.
MIM612028. gene.
neXtProtNX_A5D6W6.
PharmGKBPA165478932.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG133996.
HOGENOMHOG000112594.
InParanoidA5D6W6.
OMAALGCLSW.
OrthoDBEOG78D7KT.
PhylomeDBA5D6W6.

Gene expression databases

BgeeA5D6W6.
GenevestigatorA5D6W6.

Family and domain databases

InterProIPR019388. FIT.
[Graphical view]
PfamPF10261. Scs3p. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi161247.
NextBio88037.
PROA5D6W6.
SOURCESearch...

Entry information

Entry nameFITM1_HUMAN
AccessionPrimary (citable) accession number: A5D6W6
Secondary accession number(s): Q8IUQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: March 19, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM