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Protein

Acid phosphatase type 7

Gene

acp7

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi140IronBy similarity1
Metal bindingi169IronBy similarity1
Metal bindingi169ZincBy similarity1
Metal bindingi172IronBy similarity1
Metal bindingi204ZincBy similarity1
Metal bindingi288ZincBy similarity1
Metal bindingi338ZincBy similarity1
Metal bindingi340IronBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandIron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Acid phosphatase type 7Curated (EC:3.1.3.2)
Alternative name(s):
Purple acid phosphatase long formBy similarity
Gene namesi
Name:acp7By similarity
Synonyms:paplBy similarity
ORF Names:zgc:162913
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-070615-9 acp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000031682624 – 443Acid phosphatase type 7Add BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi76N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi355N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA5D6U8

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087672

Structurei

3D structure databases

ProteinModelPortaliA5D6U8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1378 Eukaryota
COG1409 LUCA
HOGENOMiHOG000187275
HOVERGENiHBG063988
InParanoidiA5D6U8
KOiK22390
PhylomeDBiA5D6U8

Family and domain databases

Gene3Di2.60.40.380, 1 hit
3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR008963 Purple_acid_Pase-like_N
IPR015914 Purple_acid_Pase_N
IPR025733 Purple_acid_PPase_C_dom
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PF14008 Metallophos_C, 1 hit
PF16656 Pur_ac_phosph_N, 1 hit
SUPFAMiSSF49363 SSF49363, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5D6U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPPPPPP LLLLLLCVCA VFADVPIGTQ PEQVHISYPG VQNSMLVTWS
60 70 80 90 100
SANKTDSVVE YGLWGGKLFS HSATGNSSIF INEGAEYRVM YIHRVLLTDL
110 120 130 140 150
RPAASYVYHC GSGAGWSELF FFTALNESVF FSPGFALFGD LGNENPQSLS
160 170 180 190 200
RLQKETQIGT YDVILHIGDF AYDLYEDNGR IGDEFMKQIQ SIAAYVPYMT
210 220 230 240 250
CPGNHEWAFN FSQYRARFSM PGDTEGLWYS WNVGPAHIIS FSTEVYFYYL
260 270 280 290 300
EYGLDLLFRQ YEWLRADLQE ANRPENRAER PWIITMGHRP MYCSNDDDDD
310 320 330 340 350
CTHFQSYVRL GRNDTKPPAP GLEELFYQYG VDLELWAHEH TYERLWPVYD
360 370 380 390 400
YKVFNGSSEE PYVNPKAPVH IITGSAGCRE KHDGFIPKPR DWSAFRSTDY
410 420 430 440
GYTRLQLINN THLYLEQVSD DQYGKVIDQM TLVKEKHGPD AWR
Length:443
Mass (Da):50,745
Last modified:June 12, 2007 - v1
Checksum:i50C1B424AE238465
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139891 mRNA Translation: AAI39892.1
RefSeqiNP_001092720.1, NM_001099250.1
UniGeneiDr.152233

Genome annotation databases

GeneIDi571830
KEGGidre:571830

Similar proteinsi

Entry informationi

Entry nameiACP7_DANRE
AccessioniPrimary (citable) accession number: A5D6U8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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