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Protein

Iron/zinc purple acid phosphatase-like protein

Gene

papl

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Protein has several cofactor binding sites:
  • Fe cationBy similarityNote: Binds 1 Fe cation per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi140 – 1401IronBy similarity
Metal bindingi169 – 1691IronBy similarity
Metal bindingi169 – 1691ZincBy similarity
Metal bindingi172 – 1721IronBy similarity
Metal bindingi204 – 2041ZincBy similarity
Metal bindingi288 – 2881ZincBy similarity
Metal bindingi338 – 3381ZincBy similarity
Metal bindingi340 – 3401IronBy similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Iron/zinc purple acid phosphatase-like protein (EC:3.1.3.2)
Gene namesi
Name:papl
ORF Names:zgc:162913
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-070615-9. papl.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 443420Iron/zinc purple acid phosphatase-like proteinPRO_0000316826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis
Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087672.

Structurei

3D structure databases

ProteinModelPortaliA5D6U8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000187275.
HOVERGENiHBG063988.
InParanoidiA5D6U8.
PhylomeDBiA5D6U8.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5D6U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAPPPPPP LLLLLLCVCA VFADVPIGTQ PEQVHISYPG VQNSMLVTWS
60 70 80 90 100
SANKTDSVVE YGLWGGKLFS HSATGNSSIF INEGAEYRVM YIHRVLLTDL
110 120 130 140 150
RPAASYVYHC GSGAGWSELF FFTALNESVF FSPGFALFGD LGNENPQSLS
160 170 180 190 200
RLQKETQIGT YDVILHIGDF AYDLYEDNGR IGDEFMKQIQ SIAAYVPYMT
210 220 230 240 250
CPGNHEWAFN FSQYRARFSM PGDTEGLWYS WNVGPAHIIS FSTEVYFYYL
260 270 280 290 300
EYGLDLLFRQ YEWLRADLQE ANRPENRAER PWIITMGHRP MYCSNDDDDD
310 320 330 340 350
CTHFQSYVRL GRNDTKPPAP GLEELFYQYG VDLELWAHEH TYERLWPVYD
360 370 380 390 400
YKVFNGSSEE PYVNPKAPVH IITGSAGCRE KHDGFIPKPR DWSAFRSTDY
410 420 430 440
GYTRLQLINN THLYLEQVSD DQYGKVIDQM TLVKEKHGPD AWR
Length:443
Mass (Da):50,745
Last modified:June 12, 2007 - v1
Checksum:i50C1B424AE238465
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139891 mRNA. Translation: AAI39892.1.
RefSeqiNP_001092720.1. NM_001099250.1.
UniGeneiDr.152233.

Genome annotation databases

GeneIDi571830.
KEGGidre:571830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC139891 mRNA. Translation: AAI39892.1.
RefSeqiNP_001092720.1. NM_001099250.1.
UniGeneiDr.152233.

3D structure databases

ProteinModelPortaliA5D6U8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi571830.
KEGGidre:571830.

Organism-specific databases

CTDi390928.
ZFINiZDB-GENE-070615-9. papl.

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000187275.
HOVERGENiHBG063988.
InParanoidiA5D6U8.
PhylomeDBiA5D6U8.

Miscellaneous databases

NextBioi20890713.
PROiA5D6U8.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiPAPL_DANRE
AccessioniPrimary (citable) accession number: A5D6U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: January 7, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.