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A5D6U8 (PAPL_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Iron/zinc purple acid phosphatase-like protein
EC=3.1.3.2
Gene names
Name:papl
ORF Names:zgc:162913
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandIron
Metal-binding
Zinc
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionacid phosphatase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 443420Iron/zinc purple acid phosphatase-like protein
PRO_0000316826

Sites

Metal binding1401Iron By similarity
Metal binding1691Iron By similarity
Metal binding1691Zinc By similarity
Metal binding1721Iron By similarity
Metal binding2041Zinc By similarity
Metal binding2881Zinc By similarity
Metal binding3381Zinc By similarity
Metal binding3401Iron By similarity

Amino acid modifications

Glycosylation531N-linked (GlcNAc...) Potential
Glycosylation761N-linked (GlcNAc...) Potential
Glycosylation1261N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation3131N-linked (GlcNAc...) Potential
Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation4091N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
A5D6U8 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 50C1B424AE238465

FASTA44350,745
        10         20         30         40         50         60 
MAAAPPPPPP LLLLLLCVCA VFADVPIGTQ PEQVHISYPG VQNSMLVTWS SANKTDSVVE 

        70         80         90        100        110        120 
YGLWGGKLFS HSATGNSSIF INEGAEYRVM YIHRVLLTDL RPAASYVYHC GSGAGWSELF 

       130        140        150        160        170        180 
FFTALNESVF FSPGFALFGD LGNENPQSLS RLQKETQIGT YDVILHIGDF AYDLYEDNGR 

       190        200        210        220        230        240 
IGDEFMKQIQ SIAAYVPYMT CPGNHEWAFN FSQYRARFSM PGDTEGLWYS WNVGPAHIIS 

       250        260        270        280        290        300 
FSTEVYFYYL EYGLDLLFRQ YEWLRADLQE ANRPENRAER PWIITMGHRP MYCSNDDDDD 

       310        320        330        340        350        360 
CTHFQSYVRL GRNDTKPPAP GLEELFYQYG VDLELWAHEH TYERLWPVYD YKVFNGSSEE 

       370        380        390        400        410        420 
PYVNPKAPVH IITGSAGCRE KHDGFIPKPR DWSAFRSTDY GYTRLQLINN THLYLEQVSD 

       430        440 
DQYGKVIDQM TLVKEKHGPD AWR

« Hide

References

[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC139891 mRNA. Translation: AAI39892.1.
IPIIPI00854135.
RefSeqNP_001092720.1. NM_001099250.1.
UniGeneDr.152233.

3D structure databases

ProteinModelPortalA5D6U8.
ModBaseSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000087672.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID571830.
KEGGdre:571830.

Organism-specific databases

ZFINZDB-GENE-070615-9. zgc:162913.

Phylogenomic databases

eggNOGCOG1409.
HOGENOMHOG000187275.
HOVERGENHBG063988.
InParanoidA5D6U8.
OrthoDBEOG4NS3BK.

Family and domain databases

Gene3D2.60.40.380. 1 hit.
InterProIPR004843. Metallo_PEstase_dom.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SUPFAMSSF49363. Purple_Pase_N. 1 hit.
ProtoNetSearch...

Other

NextBio20890713.

Entry information

Entry namePAPL_DANRE
AccessionPrimary (citable) accession number: A5D6U8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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