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A5D6U8

- PAPL_DANRE

UniProt

A5D6U8 - PAPL_DANRE

Protein

Iron/zinc purple acid phosphatase-like protein

Gene

papl

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    A phosphate monoester + H2O = an alcohol + phosphate.

    Cofactori

    Binds 1 iron ion per subunit.By similarity
    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi140 – 1401IronBy similarity
    Metal bindingi169 – 1691IronBy similarity
    Metal bindingi169 – 1691ZincBy similarity
    Metal bindingi172 – 1721IronBy similarity
    Metal bindingi204 – 2041ZincBy similarity
    Metal bindingi288 – 2881ZincBy similarity
    Metal bindingi338 – 3381ZincBy similarity
    Metal bindingi340 – 3401IronBy similarity

    GO - Molecular functioni

    1. acid phosphatase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Iron, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Iron/zinc purple acid phosphatase-like protein (EC:3.1.3.2)
    Gene namesi
    Name:papl
    ORF Names:zgc:162913
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-070615-9. papl.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 443420Iron/zinc purple acid phosphatase-like proteinPRO_0000316826Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi313 – 3131N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi355 – 3551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000087672.

    Structurei

    3D structure databases

    ProteinModelPortaliA5D6U8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000187275.
    HOVERGENiHBG063988.
    InParanoidiA5D6U8.
    PhylomeDBiA5D6U8.

    Family and domain databases

    Gene3Di2.60.40.380. 1 hit.
    3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR008963. Purple_acid_Pase-like_N.
    IPR015914. Purple_acid_Pase_N.
    IPR025733. Purple_acid_PPase_C_dom.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    PF14008. Metallophos_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF49363. SSF49363. 1 hit.
    SSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A5D6U8-1 [UniParc]FASTAAdd to Basket

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    MAAAPPPPPP LLLLLLCVCA VFADVPIGTQ PEQVHISYPG VQNSMLVTWS    50
    SANKTDSVVE YGLWGGKLFS HSATGNSSIF INEGAEYRVM YIHRVLLTDL 100
    RPAASYVYHC GSGAGWSELF FFTALNESVF FSPGFALFGD LGNENPQSLS 150
    RLQKETQIGT YDVILHIGDF AYDLYEDNGR IGDEFMKQIQ SIAAYVPYMT 200
    CPGNHEWAFN FSQYRARFSM PGDTEGLWYS WNVGPAHIIS FSTEVYFYYL 250
    EYGLDLLFRQ YEWLRADLQE ANRPENRAER PWIITMGHRP MYCSNDDDDD 300
    CTHFQSYVRL GRNDTKPPAP GLEELFYQYG VDLELWAHEH TYERLWPVYD 350
    YKVFNGSSEE PYVNPKAPVH IITGSAGCRE KHDGFIPKPR DWSAFRSTDY 400
    GYTRLQLINN THLYLEQVSD DQYGKVIDQM TLVKEKHGPD AWR 443
    Length:443
    Mass (Da):50,745
    Last modified:June 12, 2007 - v1
    Checksum:i50C1B424AE238465
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC139891 mRNA. Translation: AAI39892.1.
    RefSeqiNP_001092720.1. NM_001099250.1.
    UniGeneiDr.152233.

    Genome annotation databases

    GeneIDi571830.
    KEGGidre:571830.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC139891 mRNA. Translation: AAI39892.1 .
    RefSeqi NP_001092720.1. NM_001099250.1.
    UniGenei Dr.152233.

    3D structure databases

    ProteinModelPortali A5D6U8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000087672.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 571830.
    KEGGi dre:571830.

    Organism-specific databases

    CTDi 390928.
    ZFINi ZDB-GENE-070615-9. papl.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000187275.
    HOVERGENi HBG063988.
    InParanoidi A5D6U8.
    PhylomeDBi A5D6U8.

    Miscellaneous databases

    NextBioi 20890713.
    PROi A5D6U8.

    Family and domain databases

    Gene3Di 2.60.40.380. 1 hit.
    3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR008963. Purple_acid_Pase-like_N.
    IPR015914. Purple_acid_Pase_N.
    IPR025733. Purple_acid_PPase_C_dom.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    PF14008. Metallophos_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49363. SSF49363. 1 hit.
    SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.

    Entry informationi

    Entry nameiPAPL_DANRE
    AccessioniPrimary (citable) accession number: A5D6U8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3