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A5D6U8

- PAPL_DANRE

UniProt

A5D6U8 - PAPL_DANRE

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Protein

Iron/zinc purple acid phosphatase-like protein

Gene
papl, zgc:162913
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphate monoester + H2O = an alcohol + phosphate.

Cofactori

Binds 1 iron ion per subunit By similarity.
Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi140 – 1401Iron By similarity
Metal bindingi169 – 1691Iron By similarity
Metal bindingi169 – 1691Zinc By similarity
Metal bindingi172 – 1721Iron By similarity
Metal bindingi204 – 2041Zinc By similarity
Metal bindingi288 – 2881Zinc By similarity
Metal bindingi338 – 3381Zinc By similarity
Metal bindingi340 – 3401Iron By similarity

GO - Molecular functioni

  1. acid phosphatase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Iron/zinc purple acid phosphatase-like protein (EC:3.1.3.2)
Gene namesi
Name:papl
ORF Names:zgc:162913
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-070615-9. papl.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 443420Iron/zinc purple acid phosphatase-like proteinPRO_0000316826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...) Reviewed prediction
Glycosylationi76 – 761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi126 – 1261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi313 – 3131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi409 – 4091N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000087672.

Structurei

3D structure databases

ProteinModelPortaliA5D6U8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000187275.
HOVERGENiHBG063988.
InParanoidiA5D6U8.
PhylomeDBiA5D6U8.

Family and domain databases

Gene3Di2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view]
SUPFAMiSSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5D6U8-1 [UniParc]FASTAAdd to Basket

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MAAAPPPPPP LLLLLLCVCA VFADVPIGTQ PEQVHISYPG VQNSMLVTWS    50
SANKTDSVVE YGLWGGKLFS HSATGNSSIF INEGAEYRVM YIHRVLLTDL 100
RPAASYVYHC GSGAGWSELF FFTALNESVF FSPGFALFGD LGNENPQSLS 150
RLQKETQIGT YDVILHIGDF AYDLYEDNGR IGDEFMKQIQ SIAAYVPYMT 200
CPGNHEWAFN FSQYRARFSM PGDTEGLWYS WNVGPAHIIS FSTEVYFYYL 250
EYGLDLLFRQ YEWLRADLQE ANRPENRAER PWIITMGHRP MYCSNDDDDD 300
CTHFQSYVRL GRNDTKPPAP GLEELFYQYG VDLELWAHEH TYERLWPVYD 350
YKVFNGSSEE PYVNPKAPVH IITGSAGCRE KHDGFIPKPR DWSAFRSTDY 400
GYTRLQLINN THLYLEQVSD DQYGKVIDQM TLVKEKHGPD AWR 443
Length:443
Mass (Da):50,745
Last modified:June 12, 2007 - v1
Checksum:i50C1B424AE238465
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC139891 mRNA. Translation: AAI39892.1.
RefSeqiNP_001092720.1. NM_001099250.1.
UniGeneiDr.152233.

Genome annotation databases

GeneIDi571830.
KEGGidre:571830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC139891 mRNA. Translation: AAI39892.1 .
RefSeqi NP_001092720.1. NM_001099250.1.
UniGenei Dr.152233.

3D structure databases

ProteinModelPortali A5D6U8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000087672.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 571830.
KEGGi dre:571830.

Organism-specific databases

CTDi 390928.
ZFINi ZDB-GENE-070615-9. papl.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000187275.
HOVERGENi HBG063988.
InParanoidi A5D6U8.
PhylomeDBi A5D6U8.

Miscellaneous databases

NextBioi 20890713.
PROi A5D6U8.

Family and domain databases

Gene3Di 2.60.40.380. 1 hit.
3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR008963. Purple_acid_Pase-like_N.
IPR015914. Purple_acid_Pase_N.
IPR025733. Purple_acid_PPase_C_dom.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
PF14008. Metallophos_C. 1 hit.
[Graphical view ]
SUPFAMi SSF49363. SSF49363. 1 hit.
SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.

Entry informationi

Entry nameiPAPL_DANRE
AccessioniPrimary (citable) accession number: A5D6U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: June 11, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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