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A5D6P3

- A5D6P3_MOUSE

UniProt

A5D6P3 - A5D6P3_MOUSE

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Protein
Submitted name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Gene

Abcc1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette, sub-family C (CFTR/MRP), member 1Imported
Gene namesi
Name:Abcc1Imported
ORF Names:mCG_129803Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:102676. Abcc1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of plasma membrane Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriA5D6P3.

Family & Domainsi

Sequence similaritiesi

Belongs to the ABC transporter superfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG108314.
KOiK05665.
OMAiLIQCERR.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5D6P3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALRSFCSAD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF
60 70 80 90 100
PLYFFYLSRH DRGYIQMTHL NKTKTALGFF LWIICWADLF YSFWERSQGV
110 120 130 140 150
LRAPVLLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALLCAL
160 170 180 190 200
AILRSKIISA LKKDAHVDVF RDSTFYLYFT LVLVQLVLSC FSDCSPLFSE
210 220 230 240 250
TVHDRNPCPE SSASFLSRIT FWWITGMMVH GYRQPLESSD LWSLNKEDTS
260 270 280 290 300
EEVVPVLVNN WKKECDKSRK QPVRIVYAPP KDPSKPKGSS QLDVNEEVEA
310 320 330 340 350
LIVKSPHKDR EPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPKILELI
360 370 380 390 400
INFVNDREAP DWQGYFYTAL LFVSACLQTL ALHQYFHICF VSGMRIKTAV
410 420 430 440 450
VGAVYRKALL ITNAARKSST VGEIVNLMSV DAQRFMDLAT YINMIWSAPL
460 470 480 490 500
QVILALYFLW LSLGPSVLAG VAVMILMVPL NAVMAMKTKT YQVAHMKSKD
510 520 530 540 550
NRIKLMNEIL NGIKVLKLYA WELAFQDKVM SIRQEELKVL KKSAYLAAVG
560 570 580 590 600
TFTWVCTPFL VALSTFAVFV TVDERNILDA KKAFVSLALF NILRFPLNIL
610 620 630 640 650
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERRSIKSGE GNSITVKNAT
660 670 680 690 700
FTWARGEPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG
710 720 730 740 750
HVTLKGSVAY VPQQAWIQND SLRENILFGH PLQENYYKAV MEACALLPDL
760 770 780 790 800
EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNSDIYL FDDPLSAVDA
810 820 830 840 850
HVGKHIFEKV VGPMGLLKNK TRILVTHGIS YLPQVDVIIV MSGGKISEMG
860 870 880 890 900
SYQELLDRDG AFAEFLRTYA NAEQDLASED DSVSGSGKES KPVENGMLVT
910 920 930 940 950
DTVGKHLQRH LSNSSSHSGD TSQQHSSIAE LQKAGAKEET WKLMEADKAQ
960 970 980 990 1000
TGQVQLSVYW NYMKAIGLFI TFLSIFLFLC NHVSALASNY WLSLWTDDPP
1010 1020 1030 1040 1050
VVNGTQANRN FRLSVYGALG ILQGAAIFGY SMAVSIGGIF ASRRLHLDLL
1060 1070 1080 1090 1100
YNVLRSPMSF FERTPSGNLV NRFSKELDTV DSMIPQVIKM FMGSLFSVIG
1110 1120 1130 1140 1150
AVIIILLATP IAAVIIPPLG LVYFFVQRFY VASSRQLKRL ESVSRSPVYS
1160 1170 1180 1190 1200
HFNETLLGVS VIRAFEEQER FIHQSDLKVD ENQKAYYPSI VANRWLAVRL
1210 1220 1230 1240 1250
ECVGNCIVLF AALFAVISRH SLSAGLVGLS VSYSLQITAY LNWLVRMSSE
1260 1270 1280 1290 1300
METNIVAVER LKEYSETEKE APWQIQETAP PSTWPHSGRV EFRDYCLRYR
1310 1320 1330 1340 1350
EDLDLVLKHI NVTIEGGEKV GIVGRTGAGK SSLTLGLFRI NESAEGEIII
1360 1370 1380 1390 1400
DGVNIAKIGL HNLRFKITII PQDPVLFSGS LRMNLDPFSQ YSDEEVWMAL
1410 1420 1430 1440 1450
ELAHLKGFVS ALPDKLNHEC AEGGENLSVG QRQLVCLARA LLRKTKILVL
1460 1470 1480 1490 1500
DEATAAVDLE TDNLIQSTIR TQFEDCTVLT IAHRLNTIMD YTRVIVLDKG
1510 1520
EVRECGAPSE LLQQRGIFYS MAKDAGLV
Length:1,528
Mass (Da):171,185
Last modified:June 12, 2007 - v1
Checksum:i68FD13667D61DBBB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC090617 mRNA. Translation: AAH90617.1.
CH466521 Genomic DNA. Translation: EDK97393.1.
RefSeqiNP_032602.1. NM_008576.3.
UniGeneiMm.196634.

Genome annotation databases

GeneIDi17250.
KEGGimmu:17250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC090617 mRNA. Translation: AAH90617.1 .
CH466521 Genomic DNA. Translation: EDK97393.1 .
RefSeqi NP_032602.1. NM_008576.3.
UniGenei Mm.196634.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 17250.
KEGGi mmu:17250.

Organism-specific databases

CTDi 4363.
MGIi MGI:102676. Abcc1.

Phylogenomic databases

HOVERGENi HBG108314.
KOi K05665.
OMAi LIQCERR.

Miscellaneous databases

NextBioi 291714.
SOURCEi Search...

Gene expression databases

Genevestigatori A5D6P3.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR005292. Multidrug-R_assoc.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.

Entry informationi

Entry nameiA5D6P3_MOUSE
AccessioniPrimary (citable) accession number: A5D6P3
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)