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A5D6P3

- A5D6P3_MOUSE

UniProt

A5D6P3 - A5D6P3_MOUSE

Protein
Submitted name:

ATP-binding cassette, sub-family C (CFTR/MRP), member 1

Gene

Abcc1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    Keywords - Ligandi

    ATP-bindingUniRule annotationImported, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    ATP-binding cassette, sub-family C (CFTR/MRP), member 1Imported
    Gene namesi
    Name:Abcc1Imported
    ORF Names:mCG_129803Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:102676. Abcc1.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. integral component of plasma membrane Source: MGI
    3. nucleus Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriA5D6P3.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily.UniRule annotation
    Contains ABC transmembrane type-1 domains.SAAS annotation

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG108314.
    InParanoidiA5D6P3.
    KOiK05665.
    OMAiLIQCERR.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsiTIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5D6P3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALRSFCSAD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF     50
    PLYFFYLSRH DRGYIQMTHL NKTKTALGFF LWIICWADLF YSFWERSQGV 100
    LRAPVLLVSP TLLGITMLLA TFLIQLERRK GVQSSGIMLT FWLVALLCAL 150
    AILRSKIISA LKKDAHVDVF RDSTFYLYFT LVLVQLVLSC FSDCSPLFSE 200
    TVHDRNPCPE SSASFLSRIT FWWITGMMVH GYRQPLESSD LWSLNKEDTS 250
    EEVVPVLVNN WKKECDKSRK QPVRIVYAPP KDPSKPKGSS QLDVNEEVEA 300
    LIVKSPHKDR EPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPKILELI 350
    INFVNDREAP DWQGYFYTAL LFVSACLQTL ALHQYFHICF VSGMRIKTAV 400
    VGAVYRKALL ITNAARKSST VGEIVNLMSV DAQRFMDLAT YINMIWSAPL 450
    QVILALYFLW LSLGPSVLAG VAVMILMVPL NAVMAMKTKT YQVAHMKSKD 500
    NRIKLMNEIL NGIKVLKLYA WELAFQDKVM SIRQEELKVL KKSAYLAAVG 550
    TFTWVCTPFL VALSTFAVFV TVDERNILDA KKAFVSLALF NILRFPLNIL 600
    PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERRSIKSGE GNSITVKNAT 650
    FTWARGEPPT LNGITFSIPE GALVAVVGQV GCGKSSLLSA LLAEMDKVEG 700
    HVTLKGSVAY VPQQAWIQND SLRENILFGH PLQENYYKAV MEACALLPDL 750
    EILPSGDRTE IGEKGVNLSG GQKQRVSLAR AVYSNSDIYL FDDPLSAVDA 800
    HVGKHIFEKV VGPMGLLKNK TRILVTHGIS YLPQVDVIIV MSGGKISEMG 850
    SYQELLDRDG AFAEFLRTYA NAEQDLASED DSVSGSGKES KPVENGMLVT 900
    DTVGKHLQRH LSNSSSHSGD TSQQHSSIAE LQKAGAKEET WKLMEADKAQ 950
    TGQVQLSVYW NYMKAIGLFI TFLSIFLFLC NHVSALASNY WLSLWTDDPP 1000
    VVNGTQANRN FRLSVYGALG ILQGAAIFGY SMAVSIGGIF ASRRLHLDLL 1050
    YNVLRSPMSF FERTPSGNLV NRFSKELDTV DSMIPQVIKM FMGSLFSVIG 1100
    AVIIILLATP IAAVIIPPLG LVYFFVQRFY VASSRQLKRL ESVSRSPVYS 1150
    HFNETLLGVS VIRAFEEQER FIHQSDLKVD ENQKAYYPSI VANRWLAVRL 1200
    ECVGNCIVLF AALFAVISRH SLSAGLVGLS VSYSLQITAY LNWLVRMSSE 1250
    METNIVAVER LKEYSETEKE APWQIQETAP PSTWPHSGRV EFRDYCLRYR 1300
    EDLDLVLKHI NVTIEGGEKV GIVGRTGAGK SSLTLGLFRI NESAEGEIII 1350
    DGVNIAKIGL HNLRFKITII PQDPVLFSGS LRMNLDPFSQ YSDEEVWMAL 1400
    ELAHLKGFVS ALPDKLNHEC AEGGENLSVG QRQLVCLARA LLRKTKILVL 1450
    DEATAAVDLE TDNLIQSTIR TQFEDCTVLT IAHRLNTIMD YTRVIVLDKG 1500
    EVRECGAPSE LLQQRGIFYS MAKDAGLV 1528
    Length:1,528
    Mass (Da):171,185
    Last modified:June 12, 2007 - v1
    Checksum:i68FD13667D61DBBB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC090617 mRNA. Translation: AAH90617.1.
    CH466521 Genomic DNA. Translation: EDK97393.1.
    RefSeqiNP_032602.1. NM_008576.3.
    UniGeneiMm.196634.

    Genome annotation databases

    GeneIDi17250.
    KEGGimmu:17250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC090617 mRNA. Translation: AAH90617.1 .
    CH466521 Genomic DNA. Translation: EDK97393.1 .
    RefSeqi NP_032602.1. NM_008576.3.
    UniGenei Mm.196634.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 17250.
    KEGGi mmu:17250.

    Organism-specific databases

    CTDi 4363.
    MGIi MGI:102676. Abcc1.

    Phylogenomic databases

    HOVERGENi HBG108314.
    InParanoidi A5D6P3.
    KOi K05665.
    OMAi LIQCERR.

    Miscellaneous databases

    NextBioi 291714.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori A5D6P3.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR005292. Multidrug-R_assoc.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    TIGRFAMsi TIGR00957. MRP_assoc_pro. 1 hit.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.

    Entry informationi

    Entry nameiA5D6P3_MOUSE
    AccessioniPrimary (citable) accession number: A5D6P3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)