Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thymidylate kinase

Gene

tmk

Organism
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPTHE370438:GCGQ-68-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:PTH_0062
OrganismiPelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
Taxonomic identifieri370438 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaePelotomaculum
Proteomesi
  • UP000006556 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Thymidylate kinasePRO_1000076969Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi370438.PTH_0062.

Structurei

3D structure databases

ProteinModelPortaliA5D690.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5D690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGKFIVFEG VDGSGKTTQI KLLGEKLESM GCPVVYTREP GGTRVGERIR
60 70 80 90 100
EILLNPLYGE LVPWAEALLY AAARAQHVAQ VILPALREGK VVLCDRFTDS
110 120 130 140 150
SLAYQGYGRG VDIEMLEQVN RPAAAGVVPD LVLVLDFDRE GQTERMARSG
160 170 180 190 200
RSADRIEREA QEFYRRVRSG YLALAARAPR RYRVIDASRA EKLVHLDVLK
210
AAEEVLDAFL KGNSRA
Length:216
Mass (Da):23,990
Last modified:June 12, 2007 - v1
Checksum:i4B1F625E83E7CF49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009389 Genomic DNA. Translation: BAF58243.1.
RefSeqiWP_011928142.1. NC_009454.1.

Genome annotation databases

EnsemblBacteriaiBAF58243; BAF58243; PTH_0062.
KEGGipth:PTH_0062.
PATRICi22906880. VBIPelThe8413_0073.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009389 Genomic DNA. Translation: BAF58243.1.
RefSeqiWP_011928142.1. NC_009454.1.

3D structure databases

ProteinModelPortaliA5D690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi370438.PTH_0062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF58243; BAF58243; PTH_0062.
KEGGipth:PTH_0062.
PATRICi22906880. VBIPelThe8413_0073.

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
HOGENOMiHOG000229077.
KOiK00943.
OMAiGGIDIAE.
OrthoDBiEOG64JFSH.

Enzyme and pathway databases

BioCyciPTHE370438:GCGQ-68-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota."
    Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.
    Genome Res. 18:442-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13744 / JCM 10971 / SI.

Entry informationi

Entry nameiKTHY_PELTS
AccessioniPrimary (citable) accession number: A5D690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: December 9, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.