A5D5U9 (A5D5U9_PELTS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	MIS1 EMBL BAF58381.1
Synonyms:	fhs HAMAP MF_01543
Ordered Locus Names:	PTH_0200

Organism

Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP]

Taxonomic identifier

370438 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Pelotomaculum

Protein attributes

Sequence length	586 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS000559
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS000559
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS000559
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS000559 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS000559
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	73 – 80	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	A5D5U9 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 226B87F1A3B4E8CD	FASTA	586	63,953
	10 20 30 40 50 60 MAFDATRMKD FEIAEAAEAN MPSPEEWRER LGLEKSEVIP YGRICKLDFM KIAERLKNRP 70 80 90 100 110 120 DGKYIEITAI TPTPLGEGKT TTTLGLVEGL GRRGLNVGAA IRQPSGGPTM NIKGTAAGGG 130 140 150 160 170 180 NALAIPMTEF SLGLTGDIND IMNAHNLAMV ALNARMQHER NYSDEELARR NLRRLDIDPT 190 200 210 220 230 240 SVAMRWVIDF CAQGLRRIIM GIGGRMDGYL MESGFDIAVS SELMAILAVA TSLKDLRDRI 250 260 270 280 290 300 GKIIVAYDRK GNPVTTSDLE VAGAMCAYMR NAINPTLIST VEYQPVLVHA GPFANIAIGQ 310 320 330 340 350 360 SSIIADRVGL KMFDYHVTES GFAADIGFEK FWNVKCRLSG FVPNVSVITT TIRALKMHGG 370 380 390 400 410 420 GPAVVPGRPL PEEYMKENLE LLERGIPNLL HHISIVKKSG VKPVVCINAF STDTREEIAM 430 440 450 460 470 480 VRRYAEQAGA RCALSEHWLK GGEGALELAD AVIDACNEKV DFKYLYPQEM PLRQKVEVIA 490 500 510 520 530 540 REVYGADGVS WTPEAEAKAK RFESDPAFDG FATIMVKTHL SLSHDPYLKG VPKGWVLPVR 550 560 570 580 DVLVYAGAGF LCPVAGSVSM MPGTGSDPAY RRIDVDVNTG KVLGLF

References

[1]	"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota." Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K. Genome Res. 18:442-448(2008) [PubMed: 18218977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009389 Genomic DNA. Translation: BAF58381.1.
RefSeq	YP_001210750.1. NC_009454.1.
3D structure databases
ProteinModelPortal	A5D5U9.
ModBase	Search...
Protein-protein interaction databases
STRING	A5D5U9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5138493.
GenomeReviews	Gene locus PTH_0200 in contig AP009389_GR.
KEGG	pth:PTH_0200.
PATRIC	22907190. VBIPelThe8413_0228.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2759.
HOGENOM	HBG677721.
OMA	FANITHG.
ProtClustDB	PRK13507.
Enzyme and pathway databases
BioCyc	PTHE370438:PTH_0200-MONOMER.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5D5U9_PELTS

Accession

Primary (citable) accession number: A5D5U9

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)