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A5D522 (ACDH_PELTS) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene names
Name:mhpF
Ordered Locus Names:PTH_0482
OrganismPelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP]
Taxonomic identifier370438 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Pelotomaculum

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657

Catalytic activity

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657

Sequence similarities

Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
   Biological processAromatic hydrocarbons catabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic compound catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

cellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular functionNAD binding

Inferred from electronic annotation. Source: InterPro

acetaldehyde dehydrogenase (acetylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 298298Acetaldehyde dehydrogenase HAMAP MF_01657
PRO_0000387702

Regions

Nucleotide binding156 – 1649NAD By similarity

Sites

Binding site2661NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A5D522 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 26191D24090ACE6D

FASTA29831,797
        10         20         30         40         50         60 
MKKVKAAIIG PGNIGTDLMY KLLRSNYIEI ALMVGIYPQS EGLARARSLG IETSHEGIGA 

        70         80         90        100        110        120 
VLREPDIKIV FDATAAKPHL KHAPLLREAG KIAIDLTPAA VGPYMVPVVN IDEHLEADNV 

       130        140        150        160        170        180 
NMVTCGGQAT VPIVAAINRV AGVRYAEIVA SLASKSAGPG TRQNIDEFTE TTARALEVVG 

       190        200        210        220        230        240 
GAGKGKAIII LNPAEPPIMM HNTIYTLVEN PDEELIKSAV FEMVKRIQEY VPGYRLQVEP 

       250        260        270        280        290 
LVEGNKVTTI IEVTGAGDYL PPYAGNLDIM TSAAARAGEL MAMRLLGVYK PERGDSCA

« Hide

References

[1]"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota."
Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.
Genome Res. 18:442-448(2008) [PubMed: 18218977] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13744 / JCM 10971 / SI.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009389 Genomic DNA. Translation: BAF58663.1.
RefSeqYP_001211032.1. NC_009454.1.

3D structure databases

ProteinModelPortalA5D522.
SMRA5D522. Positions 2-287.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5D522.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5138859.
GenomeReviewsGene locus PTH_0482 in contig AP009389_GR.
KEGGpth:PTH_0482.
PATRIC22907826. VBIPelThe8413_0535.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG4569.
HOGENOMHBG300125.
OMAHVKNDAF.
ProtClustDBPRK08300.

Enzyme and pathway databases

BioCycPTHE370438:PTH_0482-MONOMER.

Family and domain databases

HAMAPMF_01657. Ac_ald_DH_ac.
[Tree]
InterProIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK04073.
PANTHERPTHR21123. Acetylald_dh. 1 hit.
PfamPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNetSearch...

Entry information

Entry nameACDH_PELTS
AccessionPrimary (citable) accession number: A5D522
Entry history
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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