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A5D522

- ACDH_PELTS

UniProt

A5D522 - ACDH_PELTS

Protein

Acetaldehyde dehydrogenase

Gene

mhpF

Organism
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei125 – 1251Acyl-thioester intermediateUniRule annotation
    Binding sitei266 – 2661NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi156 – 1649NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciPTHE370438:GCGQ-500-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenaseUniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating]UniRule annotation
    Gene namesi
    Name:mhpFUniRule annotation
    Ordered Locus Names:PTH_0482
    OrganismiPelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
    Taxonomic identifieri370438 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaePelotomaculum
    ProteomesiUP000006556: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298Acetaldehyde dehydrogenasePRO_0000387702Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi370438.PTH_0482.

    Structurei

    3D structure databases

    ProteinModelPortaliA5D522.
    SMRiA5D522. Positions 2-287.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    HOGENOMiHOG000052149.
    KOiK04073.
    OMAiHQGNVNM.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5D522-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKVKAAIIG PGNIGTDLMY KLLRSNYIEI ALMVGIYPQS EGLARARSLG    50
    IETSHEGIGA VLREPDIKIV FDATAAKPHL KHAPLLREAG KIAIDLTPAA 100
    VGPYMVPVVN IDEHLEADNV NMVTCGGQAT VPIVAAINRV AGVRYAEIVA 150
    SLASKSAGPG TRQNIDEFTE TTARALEVVG GAGKGKAIII LNPAEPPIMM 200
    HNTIYTLVEN PDEELIKSAV FEMVKRIQEY VPGYRLQVEP LVEGNKVTTI 250
    IEVTGAGDYL PPYAGNLDIM TSAAARAGEL MAMRLLGVYK PERGDSCA 298
    Length:298
    Mass (Da):31,797
    Last modified:June 12, 2007 - v1
    Checksum:i26191D24090ACE6D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009389 Genomic DNA. Translation: BAF58663.1.
    RefSeqiYP_001211032.1. NC_009454.1.

    Genome annotation databases

    EnsemblBacteriaiBAF58663; BAF58663; PTH_0482.
    GeneIDi5138859.
    KEGGipth:PTH_0482.
    PATRICi22907826. VBIPelThe8413_0535.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009389 Genomic DNA. Translation: BAF58663.1 .
    RefSeqi YP_001211032.1. NC_009454.1.

    3D structure databases

    ProteinModelPortali A5D522.
    SMRi A5D522. Positions 2-287.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370438.PTH_0482.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF58663 ; BAF58663 ; PTH_0482 .
    GeneIDi 5138859.
    KEGGi pth:PTH_0482.
    PATRICi 22907826. VBIPelThe8413_0535.

    Phylogenomic databases

    eggNOGi COG4569.
    HOGENOMi HOG000052149.
    KOi K04073.
    OMAi HQGNVNM.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci PTHE370438:GCGQ-500-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota."
      Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.
      Genome Res. 18:442-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13744 / JCM 10971 / SI.

    Entry informationi

    Entry nameiACDH_PELTS
    AccessioniPrimary (citable) accession number: A5D522
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3