A5D4H7 (A5D4H7_PELTS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Holo-[acyl-carrier-protein] synthase HAMAP MF_00101
Short name=Holo-ACP synthase HAMAP MF_00101
EC=2.7.8.7 HAMAP MF_00101

Alternative name(s):
4'-phosphopantetheinyl transferase AcpS HAMAP MF_00101

Gene names

Name:	AcpS EMBL BAF58837.1
Synonyms:	acpS HAMAP MF_00101
Ordered Locus Names:	PTH_0656

Organism

Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP]

Taxonomic identifier

370438 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Pelotomaculum

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP MF_00101
Catalytic activity	CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101
Cofactor	Magnesium By similarity. HAMAP MF_00101
Subcellular location	Cytoplasm By similarity HAMAP MF_00101.
Sequence similarities	Belongs to the P-Pant transferase superfamily. AcpS family. HAMAP MF_00101

Ontologies

Keywords
Biological process	Fatty acid biosynthesis HAMAP MF_00101 Lipid synthesis
Cellular component	Cytoplasm HAMAP MF_00101
Ligand	Magnesium HAMAP MF_00101 Metal-binding HAMAP MF_00101
Molecular function	Transferase HAMAP MF_00101 EMBL BAF58837.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: HAMAP macromolecule biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	34	1	Magnesium By similarity HAMAP MF_00101
	Metal binding	83	1	Magnesium By similarity HAMAP MF_00101

Sequences

	Sequence		Length	Mass (Da)
	A5D4H7 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: D3D8A907A5F4A0EA	FASTA	153	16,924
	10 20 30 40 50 60 MPAKKCNNRS FCQGVGGVSQ LWPSGAGLAG IGADIIEIER IRRAAERSNC RFLERVFTTA 70 80 90 100 110 120 ERDYCDAKRD RYACYAARFA AKEAVLKAMG RGLSGCRWSD VEIRRADEGR PEVHLHGRAA 130 140 150 EMAKERGIGQ VLVSLSHDKR RALAFAVAVR EEA

References

[1]	"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota." Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K. Genome Res. 18:442-448(2008) [PubMed: 18218977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009389 Genomic DNA. Translation: BAF58837.1.
RefSeq	YP_001211206.1. NC_009454.1.
3D structure databases
ProteinModelPortal	A5D4H7.
ModBase	Search...
Protein-protein interaction databases
STRING	A5D4H7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5138914.
GenomeReviews	Gene locus PTH_0656 in contig AP009389_GR.
KEGG	pth:PTH_0656.
PATRIC	22908244. VBIPelThe8413_0744.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0736.
HOGENOM	HBG734479.
OMA	NSSAIAY.
ProtClustDB	CLSK853781.
Enzyme and pathway databases
BioCyc	PTHE370438:PTH_0656-MONOMER.
Family and domain databases
HAMAP	MF_00101. AcpS. [Tree]
InterPro	IPR008278. 4-PPantetheinyl_Trfase. IPR002582. ACPS. IPR004568. PPantethiene-prot_Trfase. [Graphical view]
Gene3D	G3DSA:3.90.470.20. G3DSA:3.90.470.20. 1 hit.
KO	K00997.
Pfam	PF01648. ACPS. 1 hit. [Graphical view]
ProDom	PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56214. 4-PPT_transf. 1 hit.
TIGRFAMs	TIGR00516. AcpS. 1 hit. TIGR00556. Pantethn_trn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5D4H7_PELTS

Accession

Primary (citable) accession number: A5D4H7

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)