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A5D467 (A5D467_PELTS) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP MF_01405
EC=3.6.1.19 HAMAP MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP MF_01405
Nucleoside-triphosphate diphosphatase HAMAP MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP MF_01405
Gene names
Ordered Locus Names:PTH_0792
OrganismPelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP]
Taxonomic identifier370438 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Pelotomaculum

Protein attributes

Sequence length203 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. HAMAP MF_01405 SAAS SAAS020922

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. HAMAP MF_01405 SAAS SAAS020922

Subunit structure

Homodimer By similarity. HAMAP MF_01405 SAAS SAAS020922

Sequence similarities

Belongs to the HAM1 NTPase family. HAMAP MF_01405 RuleBase RU003781

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region8 – 136Substrate binding By similarity HAMAP MF_01405
Region70 – 712Substrate binding By similarity HAMAP MF_01405

Sites

Metal binding411Magnesium or manganese By similarity HAMAP MF_01405
Metal binding701Magnesium or manganese By similarity HAMAP MF_01405
Binding site1561Substrate By similarity HAMAP MF_01405
Binding site1761Substrate By similarity HAMAP MF_01405
Binding site1821Substrate By similarity HAMAP MF_01405

Sequences

Sequence LengthMass (Da)Tools
A5D467 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: C5E59E7F6E20A9EB

FASTA20322,172
        10         20         30         40         50         60 
MLKLVLATRN KNKIKEMIEL LAPSGIEALS LDQFPRIGRI EEDGRTFREN AVKKASAVCE 

        70         80         90        100        110        120 
QTGMMALADD SGLEVDCLDG APGVFSSRFA GEGSDDRANN EKLLELLTGV PPEQRRARFR 

       130        140        150        160        170        180 
CVIAIAAPDG FVYTAEGTCE GYIAEELRGE GGFGYDPLFY LPEFGKTLAE LDLKTKNKVS 

       190        200 
HRGKALLGAL DILAELKAME EQE

« Hide

References

[1]"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota."
Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.
Genome Res. 18:442-448(2008) [PubMed: 18218977] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009389 Genomic DNA. Translation: BAF58973.1.
RefSeqYP_001211342.1. NC_009454.1.

3D structure databases

ProteinModelPortalA5D467.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5D467.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5139060.
GenomeReviewsGene locus PTH_0792 in contig AP009389_GR.
KEGGpth:PTH_0792.
PATRIC22908549. VBIPelThe8413_0895.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0127.
HOGENOMHBG697237.
OMAESSTRLT.
ProtClustDBPRK14822.

Enzyme and pathway databases

BioCycPTHE370438:PTH_0792-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
[Tree]
InterProIPR002637. Ham1p-like.
IPR020922. Nucleoside-triphosphatase.
[Graphical view]
KOK02428.
PANTHERPTHR11067. Ham1p_like. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5D467_PELTS
AccessionPrimary (citable) accession number: A5D467
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info