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A5D416

- SYL_PELTS

UniProt

A5D416 - SYL_PELTS

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Protein

Leucine--tRNA ligase

Gene
leuS, PTH_0839
Organism
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei586 – 5861ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPTHE370438:GCGQ-865-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PTH_0839
OrganismiPelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
Taxonomic identifieri370438 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaePelotomaculum
ProteomesiUP000006556: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 827827Leucine--tRNA ligaseUniRule annotationPRO_0000334789Add
BLAST

Proteomic databases

PRIDEiA5D416.

Interactioni

Protein-protein interaction databases

STRINGi370438.PTH_0839.

Structurei

3D structure databases

ProteinModelPortaliA5D416.
SMRiA5D416. Positions 3-762.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionUniRule annotationAdd
BLAST
Motifi583 – 5875"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5D416-1 [UniParc]FASTAAdd to Basket

« Hide

MKERYDFKEI EEKWQARWAA QDLYAVPDYS DRPKYYCLEM FPYPSGKLHM    50
GHVRNYSIGD VVARFKTMQG YHVLHPMGWD AFGLPAENAA IKHGGVHPAE 100
WTLDNIESMR AQLKQLGISY DWNREVATCH PGYYRWTQWL FLQLFHNGLA 150
YKKKAAVNWC PGCATVLANE QVKDGGCERC KAPVEKRELE QWFFKITDYA 200
ERLLKDLELL EGWPEKVKIM QENWIGRSEG AEIDFKVEGS DDIITVYTTR 250
PDTVFGVTYM VLAPEHPLVE KLIAGSKQEA EIKEFIRKVR NLREIDRTST 300
EAEKVGMPTG AHCINPLTGE KVPVLIANYV LMEYGTGCVM GVPAHDQRDF 350
EFARKYGYPI RVVIQPPGVE LDPAAMEAAY EEEGFLVNSG PFSGMPNKEA 400
IRAITRHLEE KGRGRFRVTY RLRDWLISRQ RYWGAPIPII YCDRCGTVPV 450
PESDLPVLLP MDVEFKPTGQ SPLAECPEFV NAACPSCGGP GKRETDTMDT 500
FMCSSWYYYR YTSPRDNDAP WDRNKVDYWL PVDQYIGGVE HAILHLLYSR 550
FFTKVLYDLK LVSNLEPFSN LLTQGMVLKD GAKMSKSRGN VVSPEDIVAR 600
YGADTARLFI LFAAPPERDL EWSDQGVEGC YRFLNRVWRL VMPLAGLLKE 650
APAAVSGKLV GANREMRRVT HSTIKKVTED ISARFNFNTA VSAIMELVNA 700
LYQFREIPES DRNPAVLREA VESLLLLLAP FAPHITEELW EATGHRGSIH 750
LQPWPSYDPE AIAEDEITIV VQINGRVRER LLVPAGITPQ EMQDRVMKEP 800
RVMRMVEGKK VAKVITVPGK LVNIVIK 827
Length:827
Mass (Da):94,245
Last modified:June 12, 2007 - v1
Checksum:i963D6FAEEB49ADC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009389 Genomic DNA. Translation: BAF59020.1.
RefSeqiYP_001211389.1. NC_009454.1.

Genome annotation databases

EnsemblBacteriaiBAF59020; BAF59020; PTH_0839.
GeneIDi5140461.
KEGGipth:PTH_0839.
PATRICi22908665. VBIPelThe8413_0946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009389 Genomic DNA. Translation: BAF59020.1 .
RefSeqi YP_001211389.1. NC_009454.1.

3D structure databases

ProteinModelPortali A5D416.
SMRi A5D416. Positions 3-762.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 370438.PTH_0839.

Proteomic databases

PRIDEi A5D416.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF59020 ; BAF59020 ; PTH_0839 .
GeneIDi 5140461.
KEGGi pth:PTH_0839.
PATRICi 22908665. VBIPelThe8413_0946.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PTHE370438:GCGQ-865-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota."
    Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.
    Genome Res. 18:442-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 13744 / JCM 10971 / SI.

Entry informationi

Entry nameiSYL_PELTS
AccessioniPrimary (citable) accession number: A5D416
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi