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A5D416

- SYL_PELTS

UniProt

A5D416 - SYL_PELTS

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei586 – 5861ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPTHE370438:GCGQ-865-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PTH_0839
    OrganismiPelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI)
    Taxonomic identifieri370438 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesPeptococcaceaePelotomaculum
    ProteomesiUP000006556: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 827827Leucine--tRNA ligasePRO_0000334789Add
    BLAST

    Proteomic databases

    PRIDEiA5D416.

    Interactioni

    Protein-protein interaction databases

    STRINGi370438.PTH_0839.

    Structurei

    3D structure databases

    ProteinModelPortaliA5D416.
    SMRiA5D416. Positions 3-762.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi583 – 5875"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5D416-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKERYDFKEI EEKWQARWAA QDLYAVPDYS DRPKYYCLEM FPYPSGKLHM    50
    GHVRNYSIGD VVARFKTMQG YHVLHPMGWD AFGLPAENAA IKHGGVHPAE 100
    WTLDNIESMR AQLKQLGISY DWNREVATCH PGYYRWTQWL FLQLFHNGLA 150
    YKKKAAVNWC PGCATVLANE QVKDGGCERC KAPVEKRELE QWFFKITDYA 200
    ERLLKDLELL EGWPEKVKIM QENWIGRSEG AEIDFKVEGS DDIITVYTTR 250
    PDTVFGVTYM VLAPEHPLVE KLIAGSKQEA EIKEFIRKVR NLREIDRTST 300
    EAEKVGMPTG AHCINPLTGE KVPVLIANYV LMEYGTGCVM GVPAHDQRDF 350
    EFARKYGYPI RVVIQPPGVE LDPAAMEAAY EEEGFLVNSG PFSGMPNKEA 400
    IRAITRHLEE KGRGRFRVTY RLRDWLISRQ RYWGAPIPII YCDRCGTVPV 450
    PESDLPVLLP MDVEFKPTGQ SPLAECPEFV NAACPSCGGP GKRETDTMDT 500
    FMCSSWYYYR YTSPRDNDAP WDRNKVDYWL PVDQYIGGVE HAILHLLYSR 550
    FFTKVLYDLK LVSNLEPFSN LLTQGMVLKD GAKMSKSRGN VVSPEDIVAR 600
    YGADTARLFI LFAAPPERDL EWSDQGVEGC YRFLNRVWRL VMPLAGLLKE 650
    APAAVSGKLV GANREMRRVT HSTIKKVTED ISARFNFNTA VSAIMELVNA 700
    LYQFREIPES DRNPAVLREA VESLLLLLAP FAPHITEELW EATGHRGSIH 750
    LQPWPSYDPE AIAEDEITIV VQINGRVRER LLVPAGITPQ EMQDRVMKEP 800
    RVMRMVEGKK VAKVITVPGK LVNIVIK 827
    Length:827
    Mass (Da):94,245
    Last modified:June 12, 2007 - v1
    Checksum:i963D6FAEEB49ADC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009389 Genomic DNA. Translation: BAF59020.1.
    RefSeqiYP_001211389.1. NC_009454.1.

    Genome annotation databases

    EnsemblBacteriaiBAF59020; BAF59020; PTH_0839.
    GeneIDi5140461.
    KEGGipth:PTH_0839.
    PATRICi22908665. VBIPelThe8413_0946.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009389 Genomic DNA. Translation: BAF59020.1 .
    RefSeqi YP_001211389.1. NC_009454.1.

    3D structure databases

    ProteinModelPortali A5D416.
    SMRi A5D416. Positions 3-762.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 370438.PTH_0839.

    Proteomic databases

    PRIDEi A5D416.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF59020 ; BAF59020 ; PTH_0839 .
    GeneIDi 5140461.
    KEGGi pth:PTH_0839.
    PATRICi 22908665. VBIPelThe8413_0946.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PTHE370438:GCGQ-865-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota."
      Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.
      Genome Res. 18:442-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 13744 / JCM 10971 / SI.

    Entry informationi

    Entry nameiSYL_PELTS
    AccessioniPrimary (citable) accession number: A5D416
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3