A5D2Z8 (PPNK_PELTS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	PTH_1198

Organism

Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP]

Taxonomic identifier

370438 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Pelotomaculum

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_1000079503

Sequences

	Sequence		Length	Mass (Da)
	A5D2Z8 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: EBEBC306FC15FBBF	FASTA	291	32,264
	10 20 30 40 50 60 MNVFGLVVNL NKKEVDEVAG QIIRWLEING CRVLMEEETA RSLGLARLGV PQRQLVEQAQ 70 80 90 100 110 120 CMLVLGGDGT LLRTARRVAF SGTPVIGINL GHLGFLTEID IPDTFPSLRK LLDGQYYIEE 130 140 150 160 170 180 RMMLEARVIR QGAAVEKLLG LNDAVITKGA FARISYFEMY VNDEYVNTYS ADGIIIASPT 190 200 210 220 230 240 GSTAYSLSAG GPVVTPELDL MLITPICPHT LWARPMVIAP DSVVRVDVLK GGGEIMLTMD 250 260 270 280 290 GQHGFSLRRN DQVVVRRAEK RARFIRLKSR DFFTVLRKKL EGNRDNAKGT E

References

[1]

"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota." Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K. Genome Res. 18:442-448(2008) [PubMed: 18218977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13744 / JCM 10971 / SI.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009389 Genomic DNA. Translation: BAF59379.1.
RefSeq	YP_001211748.1. NC_009454.1.
3D structure databases
ProteinModelPortal	A5D2Z8.
ModBase	Search...
Protein-protein interaction databases
STRING	A5D2Z8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5139212.
GenomeReviews	Gene locus PTH_1198 in contig AP009389_GR.
KEGG	pth:PTH_1198.
PATRIC	22909497. VBIPelThe8413_1346.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0061.
HOGENOM	HBG713904.
OMA	LLHLKNY.
ProtClustDB	CLSK853497.
Enzyme and pathway databases
BioCyc	PTHE370438:PTH_1198-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_PELTS

Accession

Primary (citable) accession number: A5D2Z8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program