A5D2Q9 (UPPP_PELTS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	PTH_1292

Organism

Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP]

Taxonomic identifier

370438 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Pelotomaculum › Pelotomaculum thermopropionicum

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006
Catalytic activity	Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP-Rule MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Undecaprenyl-diphosphatase HAMAP-Rule MF_01006		PRO_1000083983
Regions
	Transmembrane	1 – 21	21	Helical; Potential
	Transmembrane	40 – 60	21	Helical; Potential
	Transmembrane	81 – 101	21	Helical; Potential
	Transmembrane	109 – 129	21	Helical; Potential
	Transmembrane	140 – 160	21	Helical; Potential
	Transmembrane	183 – 203	21	Helical; Potential
	Transmembrane	211 – 231	21	Helical; Potential
	Transmembrane	239 – 259	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A5D2Q9 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 3C0FE2A4148629EC	FASTA	264	28,642
	10 20 30 40 50 60 MTVFQALVLG IIQGLGEFLP ISSSAHLVLV PWLFGWQYAG LTFDVALHLG TLISIAAFFW 70 80 90 100 110 120 KEWIVLIGSA LRRRGTHEAR MFWYLVLATV PGAVMGYLLE EQAETVFRTP LLIGIMLIVM 130 140 150 160 170 180 GIFLYWADAK KPAVKGMREI SMADSLLIGL SQAFAIIPGV SRSGVTMTAG RALGLSRETA 190 200 210 220 230 240 ARFSFLLSTP IIVGAGLFKL KDITPGDVNT AFITGVASSA LVGFISISFL LKYLTGRSFA 250 260 LFVWYRLVAG LAVIVLAAAR QFGF

References

[1]

"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota." Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K. Genome Res. 18:442-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13744 / JCM 10971 / SI.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009389 Genomic DNA. Translation: BAF59473.1.
RefSeq	YP_001211842.1. NC_009454.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	370438.PTH_1292.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAF59473; BAF59473; PTH_1292.
GeneID	5138624.
KEGG	pth:PTH_1292.
PATRIC	22909713. VBIPelThe8413_1454.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1968.
HOGENOM	HOG000218357.
KO	K06153.
OMA	GTHEARM.
ProtClustDB	CLSK843050.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase.
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP_PELTS

Accession

Primary (citable) accession number: A5D2Q9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program