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A5D2F9 (DDL_PELTS) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase

EC=6.3.2.4
Alternative name(s):
D-Ala-D-Ala ligase
D-alanylalanine synthetase
Gene names
Name:ddl
Ordered Locus Names:PTH_1390
OrganismPelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP]
Taxonomic identifier370438 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesPeptococcaceaePelotomaculum

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318D-alanine--D-alanine ligase HAMAP-Rule MF_00047
PRO_0000341148

Regions

Domain101 – 307207ATP-grasp
Nucleotide binding135 – 19056ATP By similarity

Sites

Metal binding2611Magnesium or manganese 1 By similarity
Metal binding2741Magnesium or manganese 1 By similarity
Metal binding2741Magnesium or manganese 2 By similarity
Metal binding2761Magnesium or manganese 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
A5D2F9 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 8E9F2A4A0B3BC877

FASTA31834,662
        10         20         30         40         50         60 
MTLKVGVLMG GRSSEREVSL KTGEAVYNAL KVKNYLAVKI DVGLDVVERI KEERIDLAFI 

        70         80         90        100        110        120 
ALHGRYGEDG TIQGLLEMLD IPYTGSGVLA SALAMDKAAT KKIIQYEGLP TPPFMLVEKK 

       130        140        150        160        170        180 
EALKESLQAC SERICREMGL PLVVKAPTQG STIGMSFVHK EEDMAGALEL AYDYDPVALV 

       190        200        210        220        230        240 
EQFIRGTEVT ASILGNEEPV ALPLIEIVSA TGVYDYKAKY TAGMSDHIIP PRIPEKQQNA 

       250        260        270        280        290        300 
IKKLAVSTFK SLGCRGLARV DFIVDKQGNP FILEVNTIPG MTATSLFPDA ARAAGIEFPD 

       310 
LIEKLVELAM ENCGIRRR 

« Hide

References

[1]"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota."
Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.
Genome Res. 18:442-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13744 / JCM 10971 / SI.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009389 Genomic DNA. Translation: BAF59571.1.
RefSeqYP_001211940.1. NC_009454.1.

3D structure databases

ProteinModelPortalA5D2F9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING370438.PTH_1390.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF59571; BAF59571; PTH_1390.
GeneID5140071.
KEGGpth:PTH_1390.
PATRIC22909935. VBIPelThe8413_1565.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMAANDTQYR.
OrthoDBEOG6ND0KB.

Enzyme and pathway databases

BioCycPTHE370438:GCGQ-1434-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDDL_PELTS
AccessionPrimary (citable) accession number: A5D2F9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways