A5D2D8 (GCH1_PELTS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	PTH_1399

Organism

Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP]

Taxonomic identifier

370438 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Pelotomaculum › Pelotomaculum thermopropionicum

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223
Subunit structure	Homopolymer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	GTP cyclohydrolase 1 HAMAP-Rule MF_00223		PRO_1000078145
Sites
	Metal binding	76	1	Zinc By similarity
	Metal binding	79	1	Zinc By similarity
	Metal binding	148	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5D2D8 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 15761CA434899D00	FASTA	188	21,262
	10 20 30 40 50 60 MFDQHKIEKA VRLILEAIGE NPEREGLKGT PARVARMYEE IFSGLQEDPE EHLQKIFSEE 70 80 90 100 110 120 HEEMVIVKDI PLYSICEHHL LPFYGKAHVA YIPRKGKVTG LSKLARVVEG FAKRPQLQER 130 140 150 160 170 180 LTSQIADTIM RRLNPIGVLV VIEAEHMCMT FRGVKKPGSK TVTSAVRGLF RKNVATRAEA FSLIKGQA

References

[1]

"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota." Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K. Genome Res. 18:442-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: DSM 13744 / JCM 10971 / SI.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009389 Genomic DNA. Translation: BAF59580.1.
RefSeq	YP_001211949.1. NC_009454.1.
3D structure databases
ProteinModelPortal	A5D2D8.
SMR	A5D2D8. Positions 2-186.
ModBase	Search...
Protein-protein interaction databases
STRING	370438.PTH_1399.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAF59580; BAF59580; PTH_1399.
GeneID	5138368.
KEGG	pth:PTH_1399.
PATRIC	22909969. VBIPelThe8413_1580.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HOG000221222.
KO	K01495.
OMA	LYSVCEH.
ProtClustDB	PRK09347.
Enzyme and pathway databases
UniPathway	UPA00848; UER00151.
Family and domain databases
HAMAP	MF_00223. FolE.
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. PTHR11109. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_PELTS

Accession

Primary (citable) accession number: A5D2D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 12, 2007
Last modified:	May 1, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program