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A5D1T7 (A5D1T7_PELTS) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Homoserine kinase HAMAP-Rule MF_00384
Short name=HK HAMAP-Rule MF_00384
Short name=HSK HAMAP-Rule MF_00384
EC=2.7.1.39 HAMAP-Rule MF_00384
Gene names
Name:ThrB EMBL BAF59781.1
Synonyms:thrB HAMAP-Rule MF_00384
Ordered Locus Names:PTH_1600 EMBL BAF59781.1
OrganismPelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP] EMBL BAF59781.1
Taxonomic identifier370438 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Pelotomaculum ›

Protein attributes

Sequence length300 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP-Rule MF_00384

Catalytic activity

ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP-Rule MF_00384 SAAS SAAS000870

Pathway

Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP-Rule MF_00384 SAAS SAAS000870

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00384 SAAS SAAS000870.

Sequence similarities

Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP-Rule MF_00384

Sequences

Sequence LengthMass (Da)Tools
A5D1T7 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: FB5CBBB0CFD7C09A

FASTA30031,193
        10         20         30         40         50         60 
MIRVQVPATS ANLGPGFDCL GMALELYNIV EMIPASRGLV IEVSGESAAD IPRDERNLVF 

        70         80         90        100        110        120 
QAAQRVFGNT GFSPPGLKLR LINQIPAARG LGSSTAAVVG GVVAANLLSG GKLGVKDMIN 

       130        140        150        160        170        180 
LASSIEGHPD NVAPAILGGI VVSVQMDGEV KCLKIQPPQG LKGVVAVPDF PLATRTAREI 

       190        200        210        220        230        240 
LPSQVPFQDA VFNLGRVALL VAALQQGDLS LLGPAMEDRL HQSLRSSLIP GLKKVLAAAK 

       250        260        270        280        290        300 
LAGARGVTLS GAGPAVIAFA DSNFDLIARV MSDTFRQNGV KSRVMVLKPS PVGVRAFEIK

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References

[1]"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota."
Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K.
Genome Res. 18:442-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 13744 / JCM 10971 / SI.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009389 Genomic DNA. Translation: BAF59781.1.
RefSeqYP_001212150.1. NC_009454.1.

3D structure databases

ProteinModelPortalA5D1T7.
ModBaseSearch...

Protein-protein interaction databases

STRING370438.PTH_1600.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF59781; BAF59781; PTH_1600.
GeneID5138941.
KEGGpth:PTH_1600.
PATRIC22910435. VBIPelThe8413_1809.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0083.
HOGENOMHOG000247199.
KOK00872.
OMALHEPYRW.
ProtClustDBCLSK853519.

Enzyme and pathway databases

BioCycPTHE370438:GCGQ-1649-MONOMER.
UniPathwayUPA00050; UER00064.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
HAMAPMF_00384. Homoser_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR000870. Homoserine_kinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PIRSFPIRSF000676. Homoser_kin. 1 hit.
PRINTSPR00958. HOMSERKINASE.
SUPFAMSSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00191. thrB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5D1T7_PELTS
AccessionPrimary (citable) accession number: A5D1T7
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 29, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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