A5D0C3 (A5D0C3_PELTS) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	Acs EMBL BAF60312.1
Synonyms:	acsA HAMAP MF_01123
Ordered Locus Names:	PTH_2131

Organism

Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) [Complete proteome] [HAMAP]

Taxonomic identifier

370438 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Peptococcaceae › Pelotomaculum

Protein attributes

Sequence length	661 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL BAF60312.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	529	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	621	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	A5D0C3 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 419174650A26B702	FASTA	661	74,403
	10 20 30 40 50 60 MKAEKTGSVE SLLTEKRIFS PSSEFAEKAL LKSRQQYEEM WRRSIEKPDE FWAEMAEKHI 70 80 90 100 110 120 DWFKKWDAVE EYSFKDDVFV RYFRGAKLNA SYNCLDRHLN NWRRNKAALI WQGEPAEESR 130 140 150 160 170 180 TYTYLQLHRE VCKFASVLKS LGVKKGDRVT VYMPMIPELV ITLLACARIG AIHSVVFGGF 190 200 210 220 230 240 SSEALRDRII DSQAETLVTA NFGLRAGKTL NCKENADEAL SNCPAVKNCI VVRRIDRDCN 250 260 270 280 290 300 MMPGRDYWWH ELMSAATPAC EPEQMDAEDP LFILYTSGST GKPKGVMHTT GGYMVYATTT 310 320 330 340 350 360 FKYIFDYRDE DVFWCTADIG WVTGHSYIVY GPLSAGATSL MFEGVPNYPQ PDRFWEVVEK 370 380 390 400 410 420 YRVNIFYTAP TAIRAMMRDG DRWPLGRDLS SLRLLGTVGE PINPEAWMWY YKVVGKERCP 430 440 450 460 470 480 VVDTWWQTET GGILISPLPG CIPTKPGSAT VPFFGVNPKI IRQDGSEAAP NEGGYLVIDK 490 500 510 520 530 540 PWPGIMRGVY GDPNRFKNTY FVQYPGYYFT GDGARRDEDG YFWLMGRVDD VINVSGHRLG 550 560 570 580 590 600 TAEVESSLVA HPKVAEAAVV GFPHEIKGEG IYAYVTVKEG VEATEELKKE LIAHVRKEIG 610 620 630 640 650 660 PIASPDKIQF SSALPKTRSG KIIRRILRKI AAGEIGELGD TTTLADPAVV ESLVAGRLEA V

References

[1]	"The genome of Pelotomaculum thermopropionicum reveals niche-associated evolution in anaerobic microbiota." Kosaka T., Kato S., Shimoyama T., Ishii S., Abe T., Watanabe K. Genome Res. 18:442-448(2008) [PubMed: 18218977] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009389 Genomic DNA. Translation: BAF60312.1.
RefSeq	YP_001212681.1. NC_009454.1.
3D structure databases
ProteinModelPortal	A5D0C3.
SMR	A5D0C3. Positions 22-655.
ModBase	Search...
Protein-protein interaction databases
STRING	A5D0C3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5140107.
GenomeReviews	Gene locus PTH_2131 in contig AP009389_GR.
KEGG	pth:PTH_2131.
PATRIC	22911617. VBIPelThe8413_2397.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	KGKPYML.
ProtClustDB	CLSK2400113.
Enzyme and pathway databases
BioCyc	PTHE370438:PTH_2131-MONOMER.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5D0C3_PELTS

Accession

Primary (citable) accession number: A5D0C3

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)