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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei574 – 5741ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCVES412965:GHZZ-5-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:COSY_0005
OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Taxonomic identifieri412965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
ProteomesiUP000000247 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 815815Leucine--tRNA ligasePRO_1000009461Add
BLAST

Proteomic databases

PRIDEiA5CY09.

Interactioni

Protein-protein interaction databases

STRINGi412965.COSY_0005.

Structurei

3D structure databases

ProteinModelPortaliA5CY09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi571 – 5755"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5CY09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIKYDVQKI EKQAQKYWKE KKSFEVIEDY SKEKYYCLSM FPYPSGRLHM
60 70 80 90 100
GHVRNYSIGD VISRFQRMQG KNVMQPIGWD GFGLPAENAA LKNKESPAKW
110 120 130 140 150
TYKNINYMKT QLNQLGFGYD WAREITTCHP KYYRWEQWLF IKLFKKNLIY
160 170 180 190 200
KKKAIVNWDP VDQTVLANEQ VINGRGWRSN ALIEKKEISQ WFIRITNYAE
210 220 230 240 250
ELLNDLDKLY GWPDPVKIMQ KNWIGKSIGL EITFSRRNSD PLIIYTTRPD
260 270 280 290 300
TLMGVTYLAI SFEHPLALES GKNNYQVQSF IEKCKTIQTS EILNEIMDKK
310 320 330 340 350
GIDSGFKCIH PITNNEVPIW ITNFVLMSYG TGAIMSVPAH DKRDFKFAKK
360 370 380 390 400
YGIFIKQVIN KNESIDKGPI INKGKLFNSE EFSGMDFNQA YESIAKTLIE
410 420 430 440 450
KNLGNKKINY RLRDWGISRQ RYWGCPIPIV NCKYCGSVTV KVKDLPVILP
460 470 480 490 500
EKVKFYDVSS PIKKMPNFYQ TICPKCGSKA HRETDTFDTF FESSWYFARH
510 520 530 540 550
TCNNNNNAML DKRVNYWLEV DQYIGGVEHS ILHLLYARFF NKLLRDEGLI
560 570 580 590 600
KYDEPFKNLL TQGMVLKNGV KMSKSKGNTV DPTKMIKKYG ADTVRLFILF
610 620 630 640 650
AAPPMQDLEW NNSGLEGAHR FIKKVYRLVS IYINDSKDYI VNHLNINFLN
660 670 680 690 700
KTQKHIRRKI HQNLVKITDD INRRYTFNTA ISTLMESVDI INKFTKTDTQ
710 720 730 740 750
SIALRSESIN IILLTLSPIT PHICHYLWLK LGNKKAIINE PWPKVDLKAL
760 770 780 790 800
IESEVQIIIQ VDGKLRDKMM MMINTDKEIL ESEVLSNKNI IKFTKNKNII
810
KIIIIHNKLI NIVTK
Length:815
Mass (Da):95,149
Last modified:June 12, 2007 - v1
Checksum:i98F196937EC5C85E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009247 Genomic DNA. Translation: BAF61144.1.
RefSeqiWP_011929414.1. NC_009465.1.
YP_001218868.1. NC_009465.1.

Genome annotation databases

EnsemblBacteriaiBAF61144; BAF61144; COSY_0005.
KEGGivok:COSY_0005.
PATRICi32019815. VBICanVes128383_0005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009247 Genomic DNA. Translation: BAF61144.1.
RefSeqiWP_011929414.1. NC_009465.1.
YP_001218868.1. NC_009465.1.

3D structure databases

ProteinModelPortaliA5CY09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi412965.COSY_0005.

Proteomic databases

PRIDEiA5CY09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF61144; BAF61144; COSY_0005.
KEGGivok:COSY_0005.
PATRICi32019815. VBICanVes128383_0005.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciCVES412965:GHZZ-5-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 2 hits.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea clam, Calyptogena okutanii."
    Kuwahara H., Yoshida T., Takaki Y., Shimamura S., Nishi S., Harada M., Matsuyama K., Takishita K., Kawato M., Uematsu K., Fujiwara Y., Sato T., Kato C., Kitagawa M., Kato I., Maruyama T.
    Curr. Biol. 17:881-886(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HA.

Entry informationi

Entry nameiSYL_VESOH
AccessioniPrimary (citable) accession number: A5CY09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: May 27, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.