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A5CY09

- SYL_VESOH

UniProt

A5CY09 - SYL_VESOH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei574 – 5741ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCVES412965:GHZZ-5-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:COSY_0005
    OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
    Taxonomic identifieri412965 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
    ProteomesiUP000000247: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 815815Leucine--tRNA ligasePRO_1000009461Add
    BLAST

    Proteomic databases

    PRIDEiA5CY09.

    Interactioni

    Protein-protein interaction databases

    STRINGi412965.COSY_0005.

    Structurei

    3D structure databases

    ProteinModelPortaliA5CY09.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi571 – 5755"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5CY09-1 [UniParc]FASTAAdd to Basket

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    MNIKYDVQKI EKQAQKYWKE KKSFEVIEDY SKEKYYCLSM FPYPSGRLHM    50
    GHVRNYSIGD VISRFQRMQG KNVMQPIGWD GFGLPAENAA LKNKESPAKW 100
    TYKNINYMKT QLNQLGFGYD WAREITTCHP KYYRWEQWLF IKLFKKNLIY 150
    KKKAIVNWDP VDQTVLANEQ VINGRGWRSN ALIEKKEISQ WFIRITNYAE 200
    ELLNDLDKLY GWPDPVKIMQ KNWIGKSIGL EITFSRRNSD PLIIYTTRPD 250
    TLMGVTYLAI SFEHPLALES GKNNYQVQSF IEKCKTIQTS EILNEIMDKK 300
    GIDSGFKCIH PITNNEVPIW ITNFVLMSYG TGAIMSVPAH DKRDFKFAKK 350
    YGIFIKQVIN KNESIDKGPI INKGKLFNSE EFSGMDFNQA YESIAKTLIE 400
    KNLGNKKINY RLRDWGISRQ RYWGCPIPIV NCKYCGSVTV KVKDLPVILP 450
    EKVKFYDVSS PIKKMPNFYQ TICPKCGSKA HRETDTFDTF FESSWYFARH 500
    TCNNNNNAML DKRVNYWLEV DQYIGGVEHS ILHLLYARFF NKLLRDEGLI 550
    KYDEPFKNLL TQGMVLKNGV KMSKSKGNTV DPTKMIKKYG ADTVRLFILF 600
    AAPPMQDLEW NNSGLEGAHR FIKKVYRLVS IYINDSKDYI VNHLNINFLN 650
    KTQKHIRRKI HQNLVKITDD INRRYTFNTA ISTLMESVDI INKFTKTDTQ 700
    SIALRSESIN IILLTLSPIT PHICHYLWLK LGNKKAIINE PWPKVDLKAL 750
    IESEVQIIIQ VDGKLRDKMM MMINTDKEIL ESEVLSNKNI IKFTKNKNII 800
    KIIIIHNKLI NIVTK 815
    Length:815
    Mass (Da):95,149
    Last modified:June 12, 2007 - v1
    Checksum:i98F196937EC5C85E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009247 Genomic DNA. Translation: BAF61144.1.
    RefSeqiYP_001218868.1. NC_009465.1.

    Genome annotation databases

    EnsemblBacteriaiBAF61144; BAF61144; COSY_0005.
    GeneIDi5171803.
    KEGGivok:COSY_0005.
    PATRICi32019815. VBICanVes128383_0005.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009247 Genomic DNA. Translation: BAF61144.1 .
    RefSeqi YP_001218868.1. NC_009465.1.

    3D structure databases

    ProteinModelPortali A5CY09.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 412965.COSY_0005.

    Proteomic databases

    PRIDEi A5CY09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF61144 ; BAF61144 ; COSY_0005 .
    GeneIDi 5171803.
    KEGGi vok:COSY_0005.
    PATRICi 32019815. VBICanVes128383_0005.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CVES412965:GHZZ-5-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea clam, Calyptogena okutanii."
      Kuwahara H., Yoshida T., Takaki Y., Shimamura S., Nishi S., Harada M., Matsuyama K., Takishita K., Kawato M., Uematsu K., Fujiwara Y., Sato T., Kato C., Kitagawa M., Kato I., Maruyama T.
      Curr. Biol. 17:881-886(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HA.

    Entry informationi

    Entry nameiSYL_VESOH
    AccessioniPrimary (citable) accession number: A5CY09
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3