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A5CXA1

- GCH4_VESOH

UniProt

A5CXA1 - GCH4_VESOH

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Protein
GTP cyclohydrolase FolE2
Gene
folE2, COSY_0286
Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei150 – 1501May be catalytically important By similarity

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciCVES412965:GHZZ-286-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2 (EC:3.5.4.16)
Gene namesi
Name:folE2
Ordered Locus Names:COSY_0286
OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Taxonomic identifieri412965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
ProteomesiUP000000247: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264GTP cyclohydrolase FolE2UniRule annotation
PRO_0000297507Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi412965.COSY_0286.

Structurei

3D structure databases

ProteinModelPortaliA5CXA1.
SMRiA5CXA1. Positions 17-263.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiAKWFFDR.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A5CXA1-1 [UniParc]FASTAAdd to Basket

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MSATHLPDTQ NSADTRHIII DKVGIKDIIH PITYIDCDGN KMPTIGMFTM    50
TVSLPEHVKG THMSRFIEIL NENSCEFSAH NFDQIIDKVK EKLESDTAHI 100
TLNFPFFRKK EAPSSGVKSM MDYQVTLYGT LNKGEVQVMI KVVVPVTSLC 150
PCSKSISKYG AHNQRSHITI KAKVSKGRTL HIEDLIDLAE RKASCELYAL 200
LKRDDEKMVT ERAYDNPAFV EDLVRDIAVD LNADDKISYY CLESENFESI 250
HNHSAYALIE NLKC 264
Length:264
Mass (Da):29,857
Last modified:June 12, 2007 - v1
Checksum:i24EEA758A07E1F35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009247 Genomic DNA. Translation: BAF61415.1.
RefSeqiWP_011929685.1. NC_009465.1.
YP_001219139.1. NC_009465.1.

Genome annotation databases

EnsemblBacteriaiBAF61415; BAF61415; COSY_0286.
GeneIDi5172473.
KEGGivok:COSY_0286.
PATRICi32020389. VBICanVes128383_0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009247 Genomic DNA. Translation: BAF61415.1 .
RefSeqi WP_011929685.1. NC_009465.1.
YP_001219139.1. NC_009465.1.

3D structure databases

ProteinModelPortali A5CXA1.
SMRi A5CXA1. Positions 17-263.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 412965.COSY_0286.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF61415 ; BAF61415 ; COSY_0286 .
GeneIDi 5172473.
KEGGi vok:COSY_0286.
PATRICi 32020389. VBICanVes128383_0283.

Phylogenomic databases

eggNOGi COG1469.
HOGENOMi HOG000280679.
KOi K09007.
OMAi AKWFFDR.
OrthoDBi EOG6X6RBH.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .
BioCyci CVES412965:GHZZ-286-MONOMER.

Family and domain databases

HAMAPi MF_01527_B. GTP_cyclohydrol_B.
InterProi IPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view ]
Pfami PF02649. GCHY-1. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00294. TIGR00294. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea clam, Calyptogena okutanii."
    Kuwahara H., Yoshida T., Takaki Y., Shimamura S., Nishi S., Harada M., Matsuyama K., Takishita K., Kawato M., Uematsu K., Fujiwara Y., Sato T., Kato C., Kitagawa M., Kato I., Maruyama T.
    Curr. Biol. 17:881-886(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HA.

Entry informationi

Entry nameiGCH4_VESOH
AccessioniPrimary (citable) accession number: A5CXA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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