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A5CWY7

- UPPP_VESOH

UniProt

A5CWY7 - UPPP_VESOH

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, bacA, COSY_0409
Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCVES412965:GHZZ-408-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Synonyms:bacA
Ordered Locus Names:COSY_0409
OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Taxonomic identifieri412965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
ProteomesiUP000000247: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2721Helical; Reviewed prediction
Add
BLAST
Transmembranei41 – 6121Helical; Reviewed prediction
Add
BLAST
Transmembranei89 – 10921Helical; Reviewed prediction
Add
BLAST
Transmembranei114 – 13421Helical; Reviewed prediction
Add
BLAST
Transmembranei144 – 16421Helical; Reviewed prediction
Add
BLAST
Transmembranei186 – 20621Helical; Reviewed prediction
Add
BLAST
Transmembranei219 – 23921Helical; Reviewed prediction
Add
BLAST
Transmembranei244 – 26421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Undecaprenyl-diphosphataseUniRule annotation
PRO_0000303039Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi412965.COSY_0409.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiMENIGWK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5CWY7-1 [UniParc]FASTAAdd to Basket

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MDVSQTIVLA LIQGLSEFLP ISSSAHLILV PKLTNWTDQG LIFDVVVHMG    50
TLSAVIFYYQ AMIRSLFFDF YYSIIKRQII GQSKLAWGVL LGTIPIGLVG 100
MIFKDFVAVD LRSIEIIAYT TLVFGLLLGF ASWFNHKNKN PKSTISWIDV 150
SFVSMMQILA LIPGTSRSGI TITACMLVGL SRKLSIQFSF LLSIPVITLS 200
LILMLIDLYH QTQLVNVSLL VLGFVISTIS AYATIIFVIR LIDMVGMTPF 250
VIYRLILGVF LFFL 264
Length:264
Mass (Da):29,460
Last modified:June 12, 2007 - v1
Checksum:iB62BE40E0B3ABBEF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009247 Genomic DNA. Translation: BAF61528.1.
RefSeqiYP_001219252.1. NC_009465.1.

Genome annotation databases

EnsemblBacteriaiBAF61528; BAF61528; COSY_0409.
GeneIDi5172373.
KEGGivok:COSY_0409.
PATRICi32020653. VBICanVes128383_0406.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009247 Genomic DNA. Translation: BAF61528.1 .
RefSeqi YP_001219252.1. NC_009465.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 412965.COSY_0409.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF61528 ; BAF61528 ; COSY_0409 .
GeneIDi 5172373.
KEGGi vok:COSY_0409.
PATRICi 32020653. VBICanVes128383_0406.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi MENIGWK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CVES412965:GHZZ-408-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea clam, Calyptogena okutanii."
    Kuwahara H., Yoshida T., Takaki Y., Shimamura S., Nishi S., Harada M., Matsuyama K., Takishita K., Kawato M., Uematsu K., Fujiwara Y., Sato T., Kato C., Kitagawa M., Kato I., Maruyama T.
    Curr. Biol. 17:881-886(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HA.

Entry informationi

Entry nameiUPPP_VESOH
AccessioniPrimary (citable) accession number: A5CWY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi