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Protein

Peptide methionine sulfoxide reductase MsrA

Gene

msrA

Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.UniRule annotation

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.UniRule annotation
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei10UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciCVES412965:G1G2Q-594-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrAUniRule annotation (EC:1.8.4.11UniRule annotation)
Short name:
Protein-methionine-S-oxide reductaseUniRule annotation
Alternative name(s):
Peptide-methionine (S)-S-oxide reductaseUniRule annotation
Short name:
Peptide Met(O) reductaseUniRule annotation
Gene namesi
Name:msrAUniRule annotation
Ordered Locus Names:COSY_0587
OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Taxonomic identifieri412965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
Proteomesi
  • UP000000247 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000735031 – 163Peptide methionine sulfoxide reductase MsrAAdd BLAST163

Interactioni

Protein-protein interaction databases

STRINGi412965.COSY_0587

Structurei

3D structure databases

ProteinModelPortaliA5CWI5
SMRiA5CWI5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MsrA Met sulfoxide reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108HW8 Bacteria
COG0225 LUCA
HOGENOMiHOG000263863
KOiK07304
OMAiGYCAFVV
OrthoDBiPOG091H059H

Family and domain databases

Gene3Di3.30.1060.10, 1 hit
HAMAPiMF_01401 MsrA, 1 hit
InterProiView protein in InterPro
IPR002569 Met_Sox_Rdtase_MsrA
IPR036509 Met_Sox_Rdtase_MsrA_sf
PfamiView protein in Pfam
PF01625 PMSR, 1 hit
SUPFAMiSSF55068 SSF55068, 1 hit
TIGRFAMsiTIGR00401 msrA, 1 hit

Sequencei

Sequence statusi: Complete.

A5CWI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTAYFSGGC FWCVEAIFQR IVGIIKLTSG YCNGNTSNPT YQDICLGVTG
60 70 80 90 100
HAEVVKIEFD EFKISFKVLL DIFFEIHNPT TLNQQGNDRG TQYRSAIFYI
110 120 130 140 150
NNKQQLQAIN MINLMSDNIV TQVTKLDCFY PAEDYHQNYF NNNLSKPYCQ
160
MLIRPKLDKY FSQ
Length:163
Mass (Da):18,877
Last modified:June 12, 2007 - v1
Checksum:i5B1C0B69ECB82A4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009247 Genomic DNA Translation: BAF61702.1
RefSeqiWP_011929972.1, NC_009465.1

Genome annotation databases

EnsemblBacteriaiBAF61702; BAF61702; COSY_0587
KEGGivok:COSY_0587

Similar proteinsi

Entry informationi

Entry nameiMSRA_VESOH
AccessioniPrimary (citable) accession number: A5CWI5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 12, 2007
Last modified: March 28, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health