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A5CWE4

- CPDA_VESOH

UniProt

A5CWE4 - CPDA_VESOH

Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

    Cofactori

    Binds 2 metal cations per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi10 – 101Metal cation 1UniRule annotation
    Metal bindingi12 – 121Metal cation 1UniRule annotation
    Binding sitei12 – 121cAMPUniRule annotation
    Metal bindingi48 – 481Metal cation 1UniRule annotation
    Metal bindingi48 – 481Metal cation 2UniRule annotation
    Binding sitei48 – 481cAMPUniRule annotation
    Metal bindingi78 – 781Metal cation 2UniRule annotation
    Metal bindingi144 – 1441Metal cation 2UniRule annotation
    Metal bindingi183 – 1831Metal cation 2UniRule annotation
    Metal bindingi185 – 1851Metal cation 1UniRule annotation
    Binding sitei185 – 1851cAMPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi78 – 792cAMPUniRule annotation

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. nucleotide binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCVES412965:GHZZ-613-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.17UniRule annotation)
    Short name:
    3',5'-cyclic AMP phosphodiesteraseUniRule annotation
    Short name:
    cAMP phosphodiesteraseUniRule annotation
    Gene namesi
    Name:cpdAUniRule annotation
    Ordered Locus Names:COSY_0614
    OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
    Taxonomic identifieri412965 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
    ProteomesiUP000000247: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2332333',5'-cyclic adenosine monophosphate phosphodiesterase CpdAPRO_0000413382Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi412965.COSY_0614.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1409.
    HOGENOMiHOG000137387.
    KOiK03651.
    OMAiWQIIMLD.
    OrthoDBiEOG6QG8GQ.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    HAMAPiMF_00905. cAMP_phophodiest_CpdA.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5CWE4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNYSLIQISD CHIDDNKYSM GVNTHINLKK IISRISHINI DVLLITGDLT    50
    HKGSITSYKA LQQMLYPIQI KLLIIPGNHD NKNNLSATFS KNLFSQFTLG 100
    KWEIININSV QVSKTSGFLT KDELIKLELN LAQSIAQYIL ITLHHPTVPM 150
    NSTWDDSLSL ENPEALFNVL DKYHKIQAIL FGHAHQAAEF KRLGVKIISC 200
    PSTALQFNNE TRIGFNYYTL YDNGQLTINT QWI 233
    Length:233
    Mass (Da):26,503
    Last modified:June 12, 2007 - v1
    Checksum:iAC6237CF2BCF8719
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009247 Genomic DNA. Translation: BAF61727.1.
    RefSeqiWP_011929997.1. NC_009465.1.
    YP_001219451.1. NC_009465.1.

    Genome annotation databases

    EnsemblBacteriaiBAF61727; BAF61727; COSY_0614.
    GeneIDi5172048.
    KEGGivok:COSY_0614.
    PATRICi32021081. VBICanVes128383_0614.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009247 Genomic DNA. Translation: BAF61727.1 .
    RefSeqi WP_011929997.1. NC_009465.1.
    YP_001219451.1. NC_009465.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 412965.COSY_0614.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF61727 ; BAF61727 ; COSY_0614 .
    GeneIDi 5172048.
    KEGGi vok:COSY_0614.
    PATRICi 32021081. VBICanVes128383_0614.

    Phylogenomic databases

    eggNOGi COG1409.
    HOGENOMi HOG000137387.
    KOi K03651.
    OMAi WQIIMLD.
    OrthoDBi EOG6QG8GQ.

    Enzyme and pathway databases

    BioCyci CVES412965:GHZZ-613-MONOMER.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    HAMAPi MF_00905. cAMP_phophodiest_CpdA.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR026575. cAMP_Pdiest_CpdA.
    IPR029052. Metallo-depent_PP-like.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea clam, Calyptogena okutanii."
      Kuwahara H., Yoshida T., Takaki Y., Shimamura S., Nishi S., Harada M., Matsuyama K., Takishita K., Kawato M., Uematsu K., Fujiwara Y., Sato T., Kato C., Kitagawa M., Kato I., Maruyama T.
      Curr. Biol. 17:881-886(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HA.

    Entry informationi

    Entry nameiCPDA_VESOH
    AccessioniPrimary (citable) accession number: A5CWE4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3