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A5CWE4 (CPDA_VESOH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Short name=3',5'-cyclic AMP phosphodiesterase
Short name=cAMP phosphodiesterase
EC=3.1.4.17
Gene names
Name:cpdA
Ordered Locus Names:COSY_0614
OrganismVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA) [Complete proteome] [HAMAP]
Taxonomic identifier412965 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts

Protein attributes

Sequence length233 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity. HAMAP-Rule MF_00905

Catalytic activity

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate. HAMAP-Rule MF_00905

Cofactor

Binds 2 metal cations per subunit By similarity. HAMAP-Rule MF_00905

Sequence similarities

Belongs to the cAMP phosphodiesterase class-III family.

Ontologies

Keywords
   LigandcAMP
Metal-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_function3',5'-cyclic-AMP phosphodiesterase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2332333',5'-cyclic adenosine monophosphate phosphodiesterase CpdA HAMAP-Rule MF_00905
PRO_0000413382

Regions

Nucleotide binding78 – 792cAMP By similarity

Sites

Metal binding101Metal cation 1 By similarity
Metal binding121Metal cation 1 By similarity
Metal binding481Metal cation 1 By similarity
Metal binding481Metal cation 2 By similarity
Metal binding781Metal cation 2 By similarity
Metal binding1441Metal cation 2 By similarity
Metal binding1831Metal cation 2 By similarity
Metal binding1851Metal cation 1 By similarity
Binding site121cAMP By similarity
Binding site481cAMP By similarity
Binding site1851cAMP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5CWE4 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: AC6237CF2BCF8719

FASTA23326,503
        10         20         30         40         50         60 
MNYSLIQISD CHIDDNKYSM GVNTHINLKK IISRISHINI DVLLITGDLT HKGSITSYKA 

        70         80         90        100        110        120 
LQQMLYPIQI KLLIIPGNHD NKNNLSATFS KNLFSQFTLG KWEIININSV QVSKTSGFLT 

       130        140        150        160        170        180 
KDELIKLELN LAQSIAQYIL ITLHHPTVPM NSTWDDSLSL ENPEALFNVL DKYHKIQAIL 

       190        200        210        220        230 
FGHAHQAAEF KRLGVKIISC PSTALQFNNE TRIGFNYYTL YDNGQLTINT QWI 

« Hide

References

[1]"Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea clam, Calyptogena okutanii."
Kuwahara H., Yoshida T., Takaki Y., Shimamura S., Nishi S., Harada M., Matsuyama K., Takishita K., Kawato M., Uematsu K., Fujiwara Y., Sato T., Kato C., Kitagawa M., Kato I., Maruyama T.
Curr. Biol. 17:881-886(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HA.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009247 Genomic DNA. Translation: BAF61727.1.
RefSeqYP_001219451.1. NC_009465.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING412965.COSY_0614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF61727; BAF61727; COSY_0614.
GeneID5172048.
KEGGvok:COSY_0614.
PATRIC32021081. VBICanVes128383_0614.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1409.
HOGENOMHOG000137387.
KOK03651.
OMAWQIIMLD.
OrthoDBEOG6QG8GQ.

Enzyme and pathway databases

BioCycCVES412965:GHZZ-613-MONOMER.

Family and domain databases

Gene3D3.60.21.10. 1 hit.
HAMAPMF_00905. cAMP_phophodiest_CpdA.
InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMSSF56300. SSF56300. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCPDA_VESOH
AccessionPrimary (citable) accession number: A5CWE4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 12, 2007
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families