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Protein

3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA

Gene

cpdA

Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

a metal cationUniRule annotationNote: Binds 2 metal cations per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi10Metal cation 1UniRule annotation1
Metal bindingi12Metal cation 1UniRule annotation1
Binding sitei12cAMPUniRule annotation1
Metal bindingi48Metal cation 1UniRule annotation1
Metal bindingi48Metal cation 2UniRule annotation1
Binding sitei48cAMPUniRule annotation1
Metal bindingi78Metal cation 2UniRule annotation1
Metal bindingi144Metal cation 2UniRule annotation1
Metal bindingi183Metal cation 2UniRule annotation1
Metal bindingi185Metal cation 1UniRule annotation1
Binding sitei185cAMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi78 – 79cAMPUniRule annotation2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation (EC:3.1.4.53UniRule annotation)
Short name:
3',5'-cyclic AMP phosphodiesteraseUniRule annotation
Short name:
cAMP phosphodiesteraseUniRule annotation
Gene namesi
Name:cpdAUniRule annotation
Ordered Locus Names:COSY_0614
OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Taxonomic identifieri412965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
Proteomesi
  • UP000000247 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004133821 – 2333',5'-cyclic adenosine monophosphate phosphodiesterase CpdAAdd BLAST233

Interactioni

Protein-protein interaction databases

STRINGi412965.COSY_0614.

Family & Domainsi

Sequence similaritiesi

Belongs to the cAMP phosphodiesterase class-III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000137387.
KOiK03651.
OMAiESYHSFV.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

A5CWE4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYSLIQISD CHIDDNKYSM GVNTHINLKK IISRISHINI DVLLITGDLT
60 70 80 90 100
HKGSITSYKA LQQMLYPIQI KLLIIPGNHD NKNNLSATFS KNLFSQFTLG
110 120 130 140 150
KWEIININSV QVSKTSGFLT KDELIKLELN LAQSIAQYIL ITLHHPTVPM
160 170 180 190 200
NSTWDDSLSL ENPEALFNVL DKYHKIQAIL FGHAHQAAEF KRLGVKIISC
210 220 230
PSTALQFNNE TRIGFNYYTL YDNGQLTINT QWI
Length:233
Mass (Da):26,503
Last modified:June 12, 2007 - v1
Checksum:iAC6237CF2BCF8719
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009247 Genomic DNA. Translation: BAF61727.1.
RefSeqiWP_011929997.1. NC_009465.1.

Genome annotation databases

EnsemblBacteriaiBAF61727; BAF61727; COSY_0614.
KEGGivok:COSY_0614.
PATRICi32021081. VBICanVes128383_0614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009247 Genomic DNA. Translation: BAF61727.1.
RefSeqiWP_011929997.1. NC_009465.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi412965.COSY_0614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF61727; BAF61727; COSY_0614.
KEGGivok:COSY_0614.
PATRICi32021081. VBICanVes128383_0614.

Phylogenomic databases

eggNOGiENOG41070EG. Bacteria.
COG1409. LUCA.
HOGENOMiHOG000137387.
KOiK03651.
OMAiESYHSFV.
OrthoDBiPOG091H05L5.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR12905:SF7. PTHR12905:SF7. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCPDA_VESOH
AccessioniPrimary (citable) accession number: A5CWE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 12, 2007
Last modified: November 30, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.