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A5CWE4

- CPDA_VESOH

UniProt

A5CWE4 - CPDA_VESOH

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Protein
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA
Gene
cpdA, COSY_0614
Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes By similarity.UniRule annotation

Catalytic activityi

Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.UniRule annotation

Cofactori

Binds 2 metal cations per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi10 – 101Metal cation 1 By similarity
Metal bindingi12 – 121Metal cation 1 By similarity
Binding sitei12 – 121cAMP By similarity
Metal bindingi48 – 481Metal cation 1 By similarity
Metal bindingi48 – 481Metal cation 2 By similarity
Binding sitei48 – 481cAMP By similarity
Metal bindingi78 – 781Metal cation 2 By similarity
Metal bindingi144 – 1441Metal cation 2 By similarity
Metal bindingi183 – 1831Metal cation 2 By similarity
Metal bindingi185 – 1851Metal cation 1 By similarity
Binding sitei185 – 1851cAMP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 792cAMP By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-AMP phosphodiesterase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-HAMAP
  3. nucleotide binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cAMP, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCVES412965:GHZZ-613-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA (EC:3.1.4.17)
Short name:
3',5'-cyclic AMP phosphodiesterase
Short name:
cAMP phosphodiesterase
Gene namesi
Name:cpdA
Ordered Locus Names:COSY_0614
OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Taxonomic identifieri412965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
ProteomesiUP000000247: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2332333',5'-cyclic adenosine monophosphate phosphodiesterase CpdAUniRule annotation
PRO_0000413382Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi412965.COSY_0614.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1409.
HOGENOMiHOG000137387.
KOiK03651.
OMAiWQIIMLD.
OrthoDBiEOG6QG8GQ.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
HAMAPiMF_00905. cAMP_phophodiest_CpdA.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

A5CWE4-1 [UniParc]FASTAAdd to Basket

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MNYSLIQISD CHIDDNKYSM GVNTHINLKK IISRISHINI DVLLITGDLT    50
HKGSITSYKA LQQMLYPIQI KLLIIPGNHD NKNNLSATFS KNLFSQFTLG 100
KWEIININSV QVSKTSGFLT KDELIKLELN LAQSIAQYIL ITLHHPTVPM 150
NSTWDDSLSL ENPEALFNVL DKYHKIQAIL FGHAHQAAEF KRLGVKIISC 200
PSTALQFNNE TRIGFNYYTL YDNGQLTINT QWI 233
Length:233
Mass (Da):26,503
Last modified:June 12, 2007 - v1
Checksum:iAC6237CF2BCF8719
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009247 Genomic DNA. Translation: BAF61727.1.
RefSeqiWP_011929997.1. NC_009465.1.
YP_001219451.1. NC_009465.1.

Genome annotation databases

EnsemblBacteriaiBAF61727; BAF61727; COSY_0614.
GeneIDi5172048.
KEGGivok:COSY_0614.
PATRICi32021081. VBICanVes128383_0614.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009247 Genomic DNA. Translation: BAF61727.1 .
RefSeqi WP_011929997.1. NC_009465.1.
YP_001219451.1. NC_009465.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 412965.COSY_0614.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF61727 ; BAF61727 ; COSY_0614 .
GeneIDi 5172048.
KEGGi vok:COSY_0614.
PATRICi 32021081. VBICanVes128383_0614.

Phylogenomic databases

eggNOGi COG1409.
HOGENOMi HOG000137387.
KOi K03651.
OMAi WQIIMLD.
OrthoDBi EOG6QG8GQ.

Enzyme and pathway databases

BioCyci CVES412965:GHZZ-613-MONOMER.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
HAMAPi MF_00905. cAMP_phophodiest_CpdA.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR026575. cAMP_Pdiest_CpdA.
IPR029052. Metallo-depent_PP-like.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea clam, Calyptogena okutanii."
    Kuwahara H., Yoshida T., Takaki Y., Shimamura S., Nishi S., Harada M., Matsuyama K., Takishita K., Kawato M., Uematsu K., Fujiwara Y., Sato T., Kato C., Kitagawa M., Kato I., Maruyama T.
    Curr. Biol. 17:881-886(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HA.

Entry informationi

Entry nameiCPDA_VESOH
AccessioniPrimary (citable) accession number: A5CWE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: June 12, 2007
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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