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Protein

Argininosuccinate lyase

Gene

argH

Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotationSAAS annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processAmino-acid biosynthesis, Arginine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotationSAAS annotation (EC:4.3.2.1UniRule annotationSAAS annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotationImported
Ordered Locus Names:COSY_0714Imported
OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)Imported
Taxonomic identifieri412965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
Proteomesi
  • UP000000247 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi412965.COSY_0714

Structurei

3D structure databases

ProteinModelPortaliA5CW36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 324Lyase_1InterPro annotationAdd BLAST295
Domaini387 – 454ASL_C2InterPro annotationAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili148 – 168Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG4105CH7 Bacteria
COG0165 LUCA
HOGENOMiHOG000242744
KOiK01755
OMAiSIMPHKK
OrthoDBiPOG091H026A

Family and domain databases

CDDicd01359 Argininosuccinate_lyase, 1 hit
Gene3Di1.10.275.10, 2 hits
HAMAPiMF_00006 Arg_succ_lyase, 1 hit
InterProiView protein in InterPro
IPR029419 Arg_succ_lyase_C
IPR009049 Argininosuccinate_lyase
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
PANTHERiPTHR43814 PTHR43814, 1 hit
PfamiView protein in Pfam
PF14698 ASL_C2, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00838 argH, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A5CW36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNKTQQKQH TVVPKKKSRQ ITQTNQSWGG RFKEPTDEFV KIFSASIFFD
60 70 80 90 100
KILAPYDIQG SIAHATMLQE VGLLTKYEKN QIIKGLDKIL NKIKTGEFEW
110 120 130 140 150
SVTLEDVHMN IEAYLIKLIG DTGKKLHTGR SRNDQIATDI RLYLRDQVDD
160 170 180 190 200
IIRKIKRLQL VLTNLAEREM STIMPGFTHL QAAQPISFGH HMMAYFEMLA
210 220 230 240 250
RDVERLFDCR KRINSMPLGS AALAGTTYPI KRTRTAELLG FKRICLNSLD
260 270 280 290 300
GVSDRDFAIE FLSIASIIMM HLSRFSEELI LWSSTQFNFI ELHDSFCTGS
310 320 330 340 350
SIMPQKKNPD IPELVRGKTG RVYGNLTSLL TIMKSQPLAY NKDNQEDKEP
360 370 380 390 400
LFDTVDTLKA CLRVFADMIP TIQIKCDNMY NSTKQGYTTA TDLADYLVNK
410 420 430 440 450
GLPFRDAHTV VGKSVSYGIK HQKDLSELSL KELQIFDSRI ENDVFKVLSL
460 470 480
KGSLNARNHL GATSPNQVKQ TIKIARKGLK
Length:480
Mass (Da):54,563
Last modified:June 12, 2007 - v1
Checksum:i196A6E00896EF3DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009247 Genomic DNA Translation: BAF61826.1

Genome annotation databases

EnsemblBacteriaiBAF61826; BAF61826; COSY_0714
KEGGivok:COSY_0714

Similar proteinsi

Entry informationi

Entry nameiA5CW36_VESOH
AccessioniPrimary (citable) accession number: A5CW36
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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