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Protein

Adenylosuccinate lyase

Gene

purB

Organism
Vesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP.UniRule annotation

Pathwayi: AMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes AMP from IMP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Adenylosuccinate synthetase (purA)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway AMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes AMP from IMP, the pathway AMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciCVES412965:G1G2Q-901-MONOMER
UniPathwayiUPA00074; UER00132
UPA00075; UER00336

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylosuccinate lyaseUniRule annotation (EC:4.3.2.2UniRule annotation)
Short name:
ASLUniRule annotation
Alternative name(s):
AdenylosuccinaseUniRule annotation
Gene namesi
Name:purBImported
Ordered Locus Names:COSY_0886Imported
OrganismiVesicomyosocius okutanii subsp. Calyptogena okutanii (strain HA)Imported
Taxonomic identifieri412965 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriasulfur-oxidizing symbionts
Proteomesi
  • UP000000247 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi412965.COSY_0886

Structurei

3D structure databases

ProteinModelPortaliA5CVN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 311Lyase_1InterPro annotationAdd BLAST298
Domaini330 – 444ASL_CInterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QTF Bacteria
COG0015 LUCA
HOGENOMiHOG000252916
KOiK01756
OMAiTQVNPCD
OrthoDBiPOG091H01RB

Family and domain databases

Gene3Di1.10.275.10, 1 hit
InterProiView protein in InterPro
IPR024083 Fumarase/histidase_N
IPR020557 Fumarate_lyase_CS
IPR000362 Fumarate_lyase_fam
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
IPR004769 Pur_lyase
IPR013539 PurB_C
PfamiView protein in Pfam
PF08328 ASL_C, 1 hit
PF00206 Lyase_1, 1 hit
PRINTSiPR00149 FUMRATELYASE
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR00928 purB, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit

Sequencei

Sequence statusi: Complete.

A5CVN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLTELTAIS PIDGRYFEKT EILSSIFSEF GLIKYRVLIE VKWLQDMADN
60 70 80 90 100
IGIKEVSSFS QEATKFLDDI VTNFSLIDAQ EVKMIEHTIN HDVKAVEYFL
110 120 130 140 150
KDKIKGNSEL EAVSEFFHFA CTSEDINNLS YALMLLEGRN IMLTKMRELL
160 170 180 190 200
SFIAKLAENN VSVPMLSRTH GQTASPSTVG KEMANFAYRL KRQIEQLESV
210 220 230 240 250
KIMGKFNGSV GNFNAHICAY PDLDWQYISQ NFIESFGVNY AMYTTQIEPH
260 270 280 290 300
DYIAEYFHSI NRFNTVLIDF CRDIWGYVSL GYFKQKTITG EVGSSTMPHK
310 320 330 340 350
VNPIDFENGE GNLGIANAIN MYLADKLAIS RWQRDLSDST ILRNLGVSCA
360 370 380 390 400
HCLVAYASIV KGIGKLQSNK AKLTQDLDNS WEVLAEPIQT VMRRYGIENP
410 420 430 440 450
YEKLKDLTRG KTINAQVLVE FVKDLDIPDE AKITLFKLTP MTYTGDAQKL

AKAIKQLI
Length:458
Mass (Da):51,966
Last modified:June 12, 2007 - v1
Checksum:i29C51E91CB18879B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009247 Genomic DNA Translation: BAF61991.1
RefSeqiWP_011930260.1, NC_009465.1

Genome annotation databases

EnsemblBacteriaiBAF61991; BAF61991; COSY_0886
KEGGivok:COSY_0886

Similar proteinsi

Entry informationi

Entry nameiA5CVN1_VESOH
AccessioniPrimary (citable) accession number: A5CVN1
Entry historyiIntegrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health