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A5CVB8 (A5CVB8_CLAM3) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlB EMBL CAN03057.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:CMM_2970 EMBL CAN03057.1
OrganismClavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [Complete proteome] [HAMAP] EMBL CAN03057.1
Taxonomic identifier443906 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeClavibacter

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain105 – 312208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding139 – 19456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2791Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2811Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
A5CVB8 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 9164F5CB177CB585

FASTA32133,111
        10         20         30         40         50         60 
MTAHEPLSVL VLAGGISHER DVSLRSGRRV ADALRAAGVQ ASLRDPDATL LDFLRDTPPA 

        70         80         90        100        110        120 
VVWPVLHGAS GEDGALLGLL ELAGVPYVGS SARSARLAWD KPTAKAIAES AGIRTPRSVT 

       130        140        150        160        170        180 
LPKDTFRELG AAAVLRLVTE AVPAPYAVKP ARGGSAQGVT IVTDAEALPR AMVDAYTYGD 

       190        200        210        220        230        240 
VALIEQLVEG TEVAIGILDT GDGPEALPAT EIVPTSGVYG YEARYNAGLT RFFTPARISP 

       250        260        270        280        290        300 
DANAAASAAA IGIHRALGIG QMSRVDIIID AAGEPWFIEV NVIPGLTETS LLPQGLAAAG 

       310        320 
VEVGDLYRRL AEAARGASSG P 

« Hide

References

[1]"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity."
Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C. expand/collapse author list , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D.
J. Bacteriol. 190:2138-2149(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCPPB 382 EMBL CAN03057.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM711867 Genomic DNA. Translation: CAN03057.1.
RefSeqYP_001223715.1. NC_009480.1.

3D structure databases

ProteinModelPortalA5CVB8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING443906.CMM_2970.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAN03057; CAN03057; CMM_2970.
GeneID5174665.
KEGGcmi:CMM_2970.
PATRIC21456815. VBIClaMic82482_3100.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011592.
KOK01921.
OMANGELQVM.
OrthoDBEOG6ND0KB.
ProtClustDBCLSK928230.

Enzyme and pathway databases

BioCycCMIC443906:GCI2-3059-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5CVB8_CLAM3
AccessionPrimary (citable) accession number: A5CVB8
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)