A5CU73 (COAA_CLAM3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	CMM_2577

Organism

Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [Complete proteome] [HAMAP]

Taxonomic identifier

443906 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	319 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 319	319	Pantothenate kinase HAMAP MF_00215		PRO_0000325547
Regions
	Nucleotide binding	101 – 108	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A5CU73 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 216BA017A5D60C27	FASTA	319	35,665
	10 20 30 40 50 60 MPDTATGHPT SHGNVSPFVE IARADWAALA PATHLPLRET ELVQLRGIGD RLDMHEVEDV 70 80 90 100 110 120 YLPLSRLLNL YVTGTKKLHR DTSAFLGERA KSTPFIIGVA GSVAVGKSTV ARLLREMLAR 130 140 150 160 170 180 WDDTPRVELV TTDGFLHPNA ELQRRGLMER KGFPESYDRR ALLRFVTQVK SGVPEVRAPF 190 200 210 220 230 240 YSHLAYDIVP GAEVVVRQPD VLIIEGLNVL QPAASGAKLA VSDLFDFSIY VDARTHDIAQ 250 260 270 280 290 300 WYEERFLSLQ RGAFSNPRSY FHRYAELSPA EAVARARGIW SAINEPNLEQ NIRPTRSRAT 310 LVLRKDADHS VANVLLRKL

References

[1]

"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity." Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C. , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D. J. Bacteriol. 190:2138-2149(2008) [PubMed: 18192381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCPPB 382.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM711867 Genomic DNA. Translation: CAN02660.1.
RefSeq	YP_001223322.1. NC_009480.1.
3D structure databases
ProteinModelPortal	A5CU73.
SMR	A5CU73. Positions 16-319.
ModBase	Search...
Protein-protein interaction databases
STRING	A5CU73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5173153.
GenomeReviews	Gene locus CMM_2577 in contig AM711867_GR.
KEGG	cmi:CMM_2577.
PATRIC	21455997. VBIClaMic82482_2696.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
HOGENOM	HBG732538.
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Enzyme and pathway databases
BioCyc	CMIC443906:CMM_2577-MONOMER.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_CLAM3

Accession

Primary (citable) accession number: A5CU73

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program