A5CSI8 (ARLY_CLAM3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	CMM_1995

Organism

Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [Complete proteome] [HAMAP]

Taxonomic identifier

443906 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	497 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 497	497	Argininosuccinate lyase HAMAP MF_00006		PRO_0000321437

Sequences

	Sequence		Length	Mass (Da)
	A5CSI8 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: DAC98F8DB76ADC2F	FASTA	497	52,895
	10 20 30 40 50 60 MTESTDPSTR AGEAGALWGG RFAGGPSPEL VALSRSTHFD WQLAPYDIAG SRAHARALAS 70 80 90 100 110 120 AGYLSDAERQ AMLQALDTLE DRVRSGALVA SEADEDVHGA LERGLMDIAG TELGGKLRAG 130 140 150 160 170 180 RSRNDQIATL VRMYLRDHAA VIHAMLVQLV DALAAQAEAA GGAIMPGRTH LQHAQPVLLA 190 200 210 220 230 240 HHLLAHCWPL VRDLERLADW DARADVSPYG SGALAGSTLG LDAGAVARDL GFARSSENSI 250 260 270 280 290 300 DGTAARDVVA EFAFVLAQVG IDLSRLSEEI ILWNTREFGF VTLSDSFSTG SSIMPQKKNP 310 320 330 340 350 360 DIAELARGKS GRLIGNLSGL LATLKGLPLA YNRDLQEDKE PVFDSVQTLE VLLPAFTGMI 370 380 390 400 410 420 ATLRFDTDRM AELAPQGFSL ATDVAEWLVK HRVAFRDAHE VTGELVKAAE SRGVGLEDLT 430 440 450 460 470 480 DDDLRAVSPH LVPEVREVLS IEGSVASRDG AGGTARVRVD EQRAELVRRV AELRARADAA 490 AERRAAAAAS ASGEASE

References

[1]

"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity." Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C. , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D. J. Bacteriol. 190:2138-2149(2008) [PubMed: 18192381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCPPB 382.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM711867 Genomic DNA. Translation: CAN02054.1.
RefSeq	YP_001222737.1. NC_009480.1.
3D structure databases
ProteinModelPortal	A5CSI8.
ModBase	Search...
Protein-protein interaction databases
STRING	A5CSI8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5175086.
GenomeReviews	Gene locus CMM_1995 in contig AM711867_GR.
KEGG	cmi:CMM_1995.
PATRIC	21454819. VBIClaMic82482_2115.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0165.
HOGENOM	HBG539632.
OMA	MPGRTHL.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	CMIC443906:CMM_1995-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_CLAM3

Accession

Primary (citable) accession number: A5CSI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program