A5CRX8 (A5CRX8_CLAM3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441

Gene names

Name:	pyrC EMBL CAN01841.1
Ordered Locus Names:	CMM_1785

Organism

Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [Complete proteome] [HAMAP] EMBL CAN01841.1

Taxonomic identifier

443906 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195
Cofactor	Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195
Subunit structure	Homodimer By similarity. SAAS SAAS002195
Sequence similarities	Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis RuleBase RU003441 SAAS SAAS002195
Ligand	Metal-binding SAAS SAAS002195 RuleBase RU003441 Zinc RuleBase RU003441 SAAS SAAS002195
Molecular function	Hydrolase RuleBase RU003441 SAAS SAAS002195 EMBL CAN01841.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydroorotase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5CRX8 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: D2760AC396529C59	FASTA	470	49,136
	10 20 30 40 50 60 MTQNDTNPDD THLIRGATLP SGERADILVA DGLIREIGPG LETPAGAHVI EADGLVALPG 70 80 90 100 110 120 LVDLHVHLRE PGYEQSETVL TGSRAAALGG FTAVFAMANT MPVQDTAGVV EQVKALGDAA 130 140 150 160 170 180 GYATVRPIGA VSVGLAGESM AEIGAMASSR AAVRVFSDDG KCVADPLLMR RALEYVKAFD 190 200 210 220 230 240 GVIAQHAQDP RLTEGATMNE GALSGELGIT GWPAVAEESI IARDVLLAEH VGSRLHVCHV 250 260 270 280 290 300 STAGSVDVIR WAKARGVDVT AEVTPHHLLL TEDLVAGYDA RYKVNPPLRR REDVEALRQA 310 320 330 340 350 360 LADGTIDVVA TDHAPHPTEA KDCEWDAAAF GMVGLESALS VVQLAMVDTG LLDWAGVARV 370 380 390 400 410 420 MSHAPARIGR LAEHGHALAG GSPADITLYD PSASRVFDRD DLGGLSGNSP YLEMTLPGRV 430 440 450 460 470 VATFHRGYPT VLDGALVDRE SVARAAVLRD RADADARDAA TSAGVPEARA

References

[1]

"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity." Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C. , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D. J. Bacteriol. 190:2138-2149(2008) [PubMed: 18192381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM711867 Genomic DNA. Translation: CAN01841.1.
RefSeq	YP_001222528.1. NC_009480.1.
3D structure databases
ProteinModelPortal	A5CRX8.
ModBase	Search...
Protein-protein interaction databases
STRING	A5CRX8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5175183.
GenomeReviews	Gene locus CMM_1785 in contig AM711867_GR.
KEGG	cmi:CMM_1785.
PATRIC	21454383. VBIClaMic82482_1905.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0044.
HOGENOM	HBG724623.
OMA	CDVHPVG.
ProtClustDB	PRK09357.
Family and domain databases
HAMAP	MF_00220_B. PyrC_type2_B. [Tree]
InterPro	IPR006680. Amidohydro_1. IPR004722. DHOase. IPR002195. Dihydroorotase_CS. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01465.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR00857. PyrC_multi. 1 hit.
PROSITE	PS00482. DIHYDROOROTASE_1. 1 hit. PS00483. DIHYDROOROTASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5CRX8_CLAM3

Accession

Primary (citable) accession number: A5CRX8

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)