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A5CRJ9 (A5CRJ9_CLAM3) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase HAMAP MF_00116
Short name=dUTPase HAMAP MF_00116
EC=3.6.1.23 HAMAP MF_00116
Alternative name(s):
dUTP pyrophosphatase HAMAP MF_00116
Gene names
Name:dutA EMBL CAN01708.1
Synonyms:dut HAMAP MF_00116
Ordered Locus Names:CMM_1656
OrganismClavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [Complete proteome] [HAMAP] EMBL CAN01708.1
Taxonomic identifier443906 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length156 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA By similarity. HAMAP MF_00116 SAAS SAAS008181

Catalytic activity

dUTP + H2O = dUMP + diphosphate. HAMAP MF_00116 SAAS SAAS008181

Cofactor

Magnesium By similarity. HAMAP MF_00116 SAAS SAAS008181

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. HAMAP MF_00116

Sequence similarities

Belongs to the dUTPase family. HAMAP MF_00116

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region63 – 653Substrate binding By similarity HAMAP MF_00116
Region80 – 823Substrate binding By similarity HAMAP MF_00116

Sites

Binding site761Substrate By similarity HAMAP MF_00116

Sequences

Sequence LengthMass (Da)Tools
A5CRJ9 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 069630071AE3D35F

FASTA15615,831
        10         20         30         40         50         60 
MPDPVDVLIA GDAPIPAYAH PGDAGADLTA AEAVRLEPGR RATVGTGISI ALPDGYAAFV 

        70         80         90        100        110        120 
LPRSGLAARH GITIVNAPGT VDAGYRGEIR VTLLNTDADA AYDVAVGDRI AQVVVMPISR 

       130        140        150 
VRFVPVEKLP GSHRGAGGFG STGTGALPAR DPGDRT

« Hide

References

[1]"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity."
Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C. expand/collapse author list , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D.
J. Bacteriol. 190:2138-2149(2008) [PubMed: 18192381] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM711867 Genomic DNA. Translation: CAN01708.1.
RefSeqYP_001222399.1. NC_009480.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGA5CRJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5173488.
GenomeReviewsGene locus CMM_1656 in contig AM711867_GR.
KEGGcmi:CMM_1656.
PATRIC21454119. VBIClaMic82482_1775.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0756.
HOGENOMHBG436079.
OMAKIAQMVI.
ProtClustDBCLSK831200.

Family and domain databases

HAMAPMF_00116. dUTPase_bact.
[Tree]
InterProIPR008180. dUTP_pyroPase.
IPR008181. dUTP_pyroPase_sf.
[Graphical view]
KOK01520.
PANTHERPTHR11241. PTHR11241. 1 hit.
PfamPF00692. dUTPase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00576. Dut. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5CRJ9_CLAM3
AccessionPrimary (citable) accession number: A5CRJ9
Entry history
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: December 14, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info