Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydrolipoyl dehydrogenase

Gene

lpdB

Organism
Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdBImported
Ordered Locus Names:CMM_1642Imported
OrganismiClavibacter michiganensis subsp. michiganensis (strain NCPPB 382)Imported
Taxonomic identifieri443906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001564 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi443906.CMM_1642.

Structurei

3D structure databases

ProteinModelPortaliA5CRI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 317FAD/NAD-binding_domInterPro annotationAdd BLAST312
Domaini337 – 445Pyr_redox_dimInterPro annotationAdd BLAST109

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiELYNYSS.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5CRI5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQNFDVVV LGGGSGGYAA ALRAVQLGKT VGLVEKGKLG GTCLHRGCIP
60 70 80 90 100
TKALLHSAEV ADVSRESEKY GVNVTFDGVD IARVNAYREA IVASKYKGLQ
110 120 130 140 150
GLIKARGITV IEGEGRLTSA TTVQVGDQTV TGKSIVLATG SYSRTLPGLE
160 170 180 190 200
IGGRVITSEQ ALELDYIPKK VAILGGGVIG VEFASVWRSF GVDVQMIEAL
210 220 230 240 250
PHLVPNEEES ISKQFERAFR KRGIAFSLGV RFKSVTQDDQ GVQVALEDGT
260 270 280 290 300
TYDADLLLVA VGRGPATQGL GFEEAGVKTD RGFVLTDERL QTSVPGVYAV
310 320 330 340 350
GDIVPGLQLA HRGFQQGIFV AEEIAGNKPV VVEDINIPKV TYSDPEVASV
360 370 380 390 400
GYSEAKAAEK FGADKVSSYE YNLGGNGKSS ILGTAGSIKV VRVQDGPVVG
410 420 430 440 450
IHMIGARVGE LIGEGQLIVN WEAYPEDVAN LVHAHPTQNE ALGEAHLALA

GTPLHAL
Length:457
Mass (Da):48,090
Last modified:June 12, 2007 - v1
Checksum:i0BCB555D5674564E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM711867 Genomic DNA. Translation: CAN01694.1.
RefSeqiWP_012038330.1. NC_009480.1.

Genome annotation databases

EnsemblBacteriaiCAN01694; CAN01694; CMM_1642.
KEGGicmi:CMM_1642.
PATRICi21454091. VBIClaMic82482_1761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM711867 Genomic DNA. Translation: CAN01694.1.
RefSeqiWP_012038330.1. NC_009480.1.

3D structure databases

ProteinModelPortaliA5CRI5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi443906.CMM_1642.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAN01694; CAN01694; CMM_1642.
KEGGicmi:CMM_1642.
PATRICi21454091. VBIClaMic82482_1761.

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiELYNYSS.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA5CRI5_CLAM3
AccessioniPrimary (citable) accession number: A5CRI5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.