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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei618ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CMM_1547
OrganismiClavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Taxonomic identifieri443906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001564 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347431 – 851Leucine--tRNA ligaseAdd BLAST851

Proteomic databases

PRIDEiA5CR89

Interactioni

Protein-protein interaction databases

STRINGi443906.CMM_1547

Structurei

3D structure databases

ProteinModelPortaliA5CR89
SMRiA5CR89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi51 – 61"HIGH" regionAdd BLAST11
Motifi615 – 619"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiDIDWADV

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 2 hits
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

A5CR89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHETPDTPG ETYDFRAIEA EWSEVWEREQ PFRTPDASDS RPRKYILDMF
60 70 80 90 100
PYPSGDLHMG HAEAFALGDA VARYWRQQGF NVLHPIGWDS FGLPAENAAI
110 120 130 140 150
KRGVDPREWT YANIETQKQS MKRYGLSFDW ERELHTSDPE YYRWNQWLFL
160 170 180 190 200
KMHEKGLAYR KDSWVNWDPV DQTVLANEQV LPDGTSDRSG AVVVKKKLTQ
210 220 230 240 250
WYLRITDYAD RLVDDLNQLE GTWPAKVISM QRNWIGRSIG AEVDFVVEGR
260 270 280 290 300
DEPVTVFTTR PDTLHGATFM VVAPDSDLAA ELVEGASDEV RERFRGYLER
310 320 330 340 350
TQRLNEIERS TTDRPKTGIP LGRTAINPVN GERIPVWAAD YLLADYGTGA
360 370 380 390 400
VMAVPAHDQR DLDFARAFDL PVRVVVDTTQ PVTGAIRIIP EDGELPDLEE
410 420 430 440 450
VLPGRTGVAL PGEGRLINSG SLNGLSKQPA IKRVIEQLEA EGRGRAAKNY
460 470 480 490 500
RLRDWLISRQ RFWGTPIPIV YDAEGNEIRV PEDQLPVRLP DTEGLDLAPK
510 520 530 540 550
GKSPLAAATE WTNVPSPVDG SPATRDPDTM DTFMDSSWYW LRFLSPNDAT
560 570 580 590 600
KAFDPADADR WAPIDQYVGG VEHAILHLLY SRFITKVLFD LGYVTFTEPF
610 620 630 640 650
SALLNQGMVL SGGSKMSKSK GGVDLGSEMD RHGVDAIRLT MAFAGPPEDD
660 670 680 690 700
IDWEDVSPSG SAKFLARAWR LTGDITSAPE IEWKTGDEAL RRVTHRFLAE
710 720 730 740 750
APGMLEAFKF NVVIARTMEL VNAIRKTIDQ GPGGGDAAVR EATEVVAIAL
760 770 780 790 800
SLFAPYTAED MWRRLGREGS VAFAGWRKAE RNLLVQSTVT AVVQVDGKVR
810 820 830 840 850
DKLEVDAKIG ADELEALARE TAGVKRSTAG RTIDKVIVRA PKIVSITTTA

P
Length:851
Mass (Da):94,950
Last modified:June 12, 2007 - v1
Checksum:i42B1FC0B7736F1B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM711867 Genomic DNA Translation: CAN01594.1
RefSeqiWP_012038234.1, NC_009480.1

Genome annotation databases

EnsemblBacteriaiCAN01594; CAN01594; CMM_1547
KEGGicmi:CMM_1547

Similar proteinsi

Entry informationi

Entry nameiSYL_CLAM3
AccessioniPrimary (citable) accession number: A5CR89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 12, 2007
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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