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A5CR33

- PROB_CLAM3

UniProt

A5CR33 - PROB_CLAM3

Protein

Glutamate 5-kinase

Gene

proB

Organism
Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei18 – 181ATPUniRule annotation
    Binding sitei54 – 541SubstrateUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation
    Binding sitei153 – 1531Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi173 – 1742ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCMIC443906:GCI2-1537-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:CMM_1492
    OrganismiClavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
    Taxonomic identifieri443906 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeClavibacter
    ProteomesiUP000001564: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 259259Glutamate 5-kinasePRO_1000081050Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi443906.CMM_1492.

    Structurei

    3D structure databases

    ProteinModelPortaliA5CR33.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiQENEEFA.
    OrthoDBiEOG6PGK7G.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5CR33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTASRAGIA SARRIVVKVG SSSISGDNAG QIAPLVDAIA SVHARGAEVV    50
    LVSSGAIATG MPFLRLDDRP ADLATQQAAA AVGQSVLIFR YQESLDRYGI 100
    VAGQVLLTAG DLAAPDHREN AQRAMERLLG LRLLPIVNEN DTVATHEIRF 150
    GDNDRLAALV ARLVDADLLL LLSDVDALYT RPPEEPGARR IEHVGFGDEL 200
    DGVEIGSTGT GVGTGGAVTK VAAARLAAEA GTGVLLTSTA QVHSALAGEH 250
    VGTWFAPRG 259
    Length:259
    Mass (Da):26,711
    Last modified:June 12, 2007 - v1
    Checksum:iCB591178832895AE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM711867 Genomic DNA. Translation: CAN01538.1.
    RefSeqiYP_001222233.1. NC_009480.1.

    Genome annotation databases

    EnsemblBacteriaiCAN01538; CAN01538; CMM_1492.
    GeneIDi5175636.
    KEGGicmi:CMM_1492.
    PATRICi21453771. VBIClaMic82482_1605.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM711867 Genomic DNA. Translation: CAN01538.1 .
    RefSeqi YP_001222233.1. NC_009480.1.

    3D structure databases

    ProteinModelPortali A5CR33.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 443906.CMM_1492.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAN01538 ; CAN01538 ; CMM_1492 .
    GeneIDi 5175636.
    KEGGi cmi:CMM_1492.
    PATRICi 21453771. VBIClaMic82482_1605.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi QENEEFA.
    OrthoDBi EOG6PGK7G.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci CMIC443906:GCI2-1537-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity."
      Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C.
      , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D.
      J. Bacteriol. 190:2138-2149(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: NCPPB 382.

    Entry informationi

    Entry nameiPROB_CLAM3
    AccessioniPrimary (citable) accession number: A5CR33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3