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A5CPY6 (ILVC_CLAM3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase

EC=1.1.1.86
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene names
Name:ilvC
Ordered Locus Names:CMM_1096
OrganismClavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [Complete proteome] [HAMAP]
Taxonomic identifier443906 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeClavibacter

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP-Rule MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP-Rule MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP-Rule MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Ketol-acid reductoisomerase HAMAP-Rule MF_00435
PRO_1000050501

Sites

Active site1081 Potential

Sequences

Sequence LengthMass (Da)Tools
A5CPY6 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: AABD78C6E9F6740B

FASTA34137,171
        10         20         30         40         50         60 
MTDIVYDKDA DLSLIQGRKV AVIGYGSQGH AHALNLRDSG VEVVIGLKEG STSRAKAEEQ 

        70         80         90        100        110        120 
GFTVKTPSDA SAWADVIVIL APDQHQRGLY ADSVRDNLTE GKTLVFAHGF NIRFGYIEAP 

       130        140        150        160        170        180 
EGVDVVLVAP KGPGHTVRRE FEAGRGVPVI VAVEVDASGK AWDLAWSYAK GIGGLRAGGI 

       190        200        210        220        230        240 
RTTFTEETET DLFGEQAVLC GGTSQLVQYG FETLMEAGYQ PQIAYFEVLH ELKLIVDLMW 

       250        260        270        280        290        300 
EGGIAKQRWS ISDTAEYGDY VSGPRVISPD VKENMKAVLA DIQSGAFADR FIKDQDAGAP 

       310        320        330        340 
EFLELRKKGE EHPIESTGRE LRKLFAWNKA DDDYTDGSVA R 

« Hide

References

[1]"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity."
Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C. expand/collapse author list , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D.
J. Bacteriol. 190:2138-2149(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: NCPPB 382.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM711867 Genomic DNA. Translation: CAN01139.1.
RefSeqYP_001221837.1. NC_009480.1.

3D structure databases

ProteinModelPortalA5CPY6.
SMRA5CPY6. Positions 3-327.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING443906.CMM_1096.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAN01139; CAN01139; CMM_1096.
GeneID5173472.
KEGGcmi:CMM_1096.
PATRIC21452937. VBIClaMic82482_1196.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0059.
HOGENOMHOG000016230.
KOK00053.
OMAKQRWSVS.
OrthoDBEOG625K07.
ProtClustDBPRK05479.

Enzyme and pathway databases

BioCycCMIC443906:GCI2-1128-MONOMER.
UniPathwayUPA00047; UER00056.
UPA00049; UER00060.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
HAMAPMF_00435. IlvC.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERPTHR21371. PTHR21371. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00465. ilvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameILVC_CLAM3
AccessionPrimary (citable) accession number: A5CPY6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: February 19, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways