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A5CPY6

- ILVC_CLAM3

UniProt

A5CPY6 - ILVC_CLAM3

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Protein
Ketol-acid reductoisomerase
Gene
ilvC, CMM_1096
Organism
Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH.UniRule annotation
(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei108 – 1081 Reviewed prediction

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. ketol-acid reductoisomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. isoleucine biosynthetic process Source: UniProtKB-HAMAP
  2. valine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCMIC443906:GCI2-1128-MONOMER.
UniPathwayiUPA00047; UER00056.
UPA00049; UER00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Ketol-acid reductoisomerase (EC:1.1.1.86)
Alternative name(s):
Acetohydroxy-acid isomeroreductase
Alpha-keto-beta-hydroxylacyl reductoisomerase
Gene namesi
Name:ilvC
Ordered Locus Names:CMM_1096
OrganismiClavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Taxonomic identifieri443906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeClavibacter
ProteomesiUP000001564: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Ketol-acid reductoisomeraseUniRule annotation
PRO_1000050501Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi443906.CMM_1096.

Structurei

3D structure databases

ProteinModelPortaliA5CPY6.
SMRiA5CPY6. Positions 3-327.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0059.
HOGENOMiHOG000016230.
KOiK00053.
OMAiASWNTIK.
OrthoDBiEOG625K07.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
HAMAPiMF_00435. IlvC.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
PANTHERiPTHR21371. PTHR21371. 1 hit.
PfamiPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00465. ilvC. 1 hit.

Sequencei

Sequence statusi: Complete.

A5CPY6-1 [UniParc]FASTAAdd to Basket

« Hide

MTDIVYDKDA DLSLIQGRKV AVIGYGSQGH AHALNLRDSG VEVVIGLKEG    50
STSRAKAEEQ GFTVKTPSDA SAWADVIVIL APDQHQRGLY ADSVRDNLTE 100
GKTLVFAHGF NIRFGYIEAP EGVDVVLVAP KGPGHTVRRE FEAGRGVPVI 150
VAVEVDASGK AWDLAWSYAK GIGGLRAGGI RTTFTEETET DLFGEQAVLC 200
GGTSQLVQYG FETLMEAGYQ PQIAYFEVLH ELKLIVDLMW EGGIAKQRWS 250
ISDTAEYGDY VSGPRVISPD VKENMKAVLA DIQSGAFADR FIKDQDAGAP 300
EFLELRKKGE EHPIESTGRE LRKLFAWNKA DDDYTDGSVA R 341
Length:341
Mass (Da):37,171
Last modified:June 12, 2007 - v1
Checksum:iAABD78C6E9F6740B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM711867 Genomic DNA. Translation: CAN01139.1.
RefSeqiYP_001221837.1. NC_009480.1.

Genome annotation databases

EnsemblBacteriaiCAN01139; CAN01139; CMM_1096.
GeneIDi5173472.
KEGGicmi:CMM_1096.
PATRICi21452937. VBIClaMic82482_1196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM711867 Genomic DNA. Translation: CAN01139.1 .
RefSeqi YP_001221837.1. NC_009480.1.

3D structure databases

ProteinModelPortali A5CPY6.
SMRi A5CPY6. Positions 3-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 443906.CMM_1096.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAN01139 ; CAN01139 ; CMM_1096 .
GeneIDi 5173472.
KEGGi cmi:CMM_1096.
PATRICi 21452937. VBIClaMic82482_1196.

Phylogenomic databases

eggNOGi COG0059.
HOGENOMi HOG000016230.
KOi K00053.
OMAi ASWNTIK.
OrthoDBi EOG625K07.

Enzyme and pathway databases

UniPathwayi UPA00047 ; UER00056 .
UPA00049 ; UER00060 .
BioCyci CMIC443906:GCI2-1128-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
HAMAPi MF_00435. IlvC.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view ]
PANTHERi PTHR21371. PTHR21371. 1 hit.
Pfami PF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00465. ilvC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity."
    Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C.
    , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D.
    J. Bacteriol. 190:2138-2149(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCPPB 382.

Entry informationi

Entry nameiILVC_CLAM3
AccessioniPrimary (citable) accession number: A5CPY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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