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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1088ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCMIC443906:GCI2-1085-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:CMM_1054
OrganismiClavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Taxonomic identifieri443906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesMicrobacteriaceaeClavibacter
Proteomesi
  • UP000001564 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 941941Protein translocase subunit SecAPRO_0000318334Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi443906.CMM_1054.

Structurei

3D structure databases

ProteinModelPortaliA5CPU4.
SMRiA5CPU4. Positions 1-830.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5CPU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLEKVLR VGEGRTLRKL QNYAKAVNQL EEDFTHLTDE ELKNETVELR
60 70 80 90 100
ERHANGESLD DLLPEAFAAV REASRRTLGL RHFDVQIMGG AALHLGNIAE
110 120 130 140 150
MKTGEGKTLV ATLPAYLNAI ASRGVHVITV NDYLASYQSE LMGRVFRALG
160 170 180 190 200
MTTGVILAGQ TPQQRREQYA ADITYGTNNE FGFDYLRDNM AWQASDMVQR
210 220 230 240 250
GHFFAVVDEV DSILIDEART PLIISGPSAG DANRWFTEFA TVAKRLVPEV
260 270 280 290 300
DYEVDEKKRT VGVLEAGIEK VEDHLGIDNL YESANTPLIS FLNNSIKAKA
310 320 330 340 350
LFKKDKDYVV MNGEVLIVDE HTGRILMGRR YNEGIHQAIE AKEGVAVKAE
360 370 380 390 400
NQTLATVTLQ NYFRLYKKLS GMTGTAETEA AEFMSTYKLG VVPIPTNRPM
410 420 430 440 450
QRKDQSDLIY KNEKAKFEQV VEDIAERHAA GQPVLVGTTS VEKSEYLSKL
460 470 480 490 500
LAKKGVRHEV LNAKNHAREA AIVAQAGRLG SVTVATNMAG RGTDIMLGGN
510 520 530 540 550
AEFLAVAAMN ARGLSPVETP EQYETEWDDV FADVKAEVDE EAAKVIEAGG
560 570 580 590 600
LYVLGTERHE SRRIDNQLRG RSGRQGDPGE SRFYLSLTDD LMRLFNNGAA
610 620 630 640 650
ASLMGRDSVP DDVAIESKVV SRAIRSAQGQ VEARNAEIRK NVLKYDDVLN
660 670 680 690 700
RQREAIYGDR RHILEGDDLQ ERSQRFLEAV IDDVLDSHIG EGNGDDWDFD
710 720 730 740 750
ALWTELKTLY PISITIDEVI TEAGSKGRVN RDFVRREILS DAKLAYSKRE
760 770 780 790 800
EQLGGAAMRE LERRVVLSVI DRRWREHLYE MDYLKDGIGL RAMAQRDPLV
810 820 830 840 850
EYQREGFALF QQMMGAIREE TVGFLFNLEV EVQAPADAES VGPRIQAKGL
860 870 880 890 900
AANQATADKL RYTAPTDDGG VEVRNQRGQI EKAATAKAQK DQQAEDAVLV
910 920 930 940
GEDEPETPQG PPARGAFGQP TGASSSAPQN REERRKADRR K
Length:941
Mass (Da):104,567
Last modified:June 12, 2007 - v1
Checksum:i6860F7AACA89C0ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM711867 Genomic DNA. Translation: CAN01093.1.
RefSeqiWP_012037740.1. NC_009480.1.

Genome annotation databases

EnsemblBacteriaiCAN01093; CAN01093; CMM_1054.
KEGGicmi:CMM_1054.
PATRICi21452847. VBIClaMic82482_1152.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM711867 Genomic DNA. Translation: CAN01093.1.
RefSeqiWP_012037740.1. NC_009480.1.

3D structure databases

ProteinModelPortaliA5CPU4.
SMRiA5CPU4. Positions 1-830.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi443906.CMM_1054.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAN01093; CAN01093; CMM_1054.
KEGGicmi:CMM_1054.
PATRICi21452847. VBIClaMic82482_1152.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218168.
KOiK03070.
OMAiIATERHE.

Enzyme and pathway databases

BioCyciCMIC443906:GCI2-1085-MONOMER.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA_CLAM3
AccessioniPrimary (citable) accession number: A5CPU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 12, 2007
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.