A5CPG1 (A5CPG1_CLAM3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA1 EMBL CAN00959.1
Synonyms:	acsA HAMAP MF_01123
Ordered Locus Names:	CMM_0922

Organism

Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [Complete proteome] [HAMAP] EMBL CAN00959.1

Taxonomic identifier

443906 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	679 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123 EMBL CAN00959.1
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	547	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	642	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	A5CPG1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: BB18065026C81A51	FASTA	679	73,576
	10 20 30 40 50 60 MTMSTNPRST QPGASSPAAP DQDEEGTTIP SRPATTAEPG PVHPPSEAFR ATRVADESLA 70 80 90 100 110 120 ASAAADRLGF WADRARELLT WETPFETVLD WSDAPVARWF PEGRLNVAYN CLDRHVLAGH 130 140 150 160 170 180 GDRVALHWEG EPGDTRDLTY AELTAEVKRA ANALGDLGVV AGDRVAIYLP MIPEAVIAML 190 200 210 220 230 240 AVARIGAVHS VVFGGFSAES LRARIDDAAA RVVITADGGW RKGKVFPLKP AVDAALVGSA 250 260 270 280 290 300 GSVEHVLVVR RGENQVDWDE SRDLWWHERV AAADPEHEAE AFEAEHPLFI LYTSGTTGKP 310 320 330 340 350 360 KGILHTSGGY LTQAAYTHRN VFDLHPETDV YWCTADVGWI TGHSYVVYGP LANGATQVVY 370 380 390 400 410 420 EGTPDTPEPG RWWDIVEKHG VTILYAAPTA IRSFMKTGRE IPDARDLSSI RLLGSVGEPI 430 440 450 460 470 480 NPEAWRWYRD VIGGGDVPVV DTWWQTETGG IMISALPGIT ATKPGSAQSP IPGIEVAVVD 490 500 510 520 530 540 DQGEPVSRGE SGLLVVTEPW PGMLRGIWGD PERYRETYWD RFGDRYFAGD GARLDEDGDI 550 560 570 580 590 600 WLLGRVDDVM NVSGHRLSTA EIESSLVAHP YVAEAAVVGA SDEATGQAVV AFVILRSAEA 610 620 630 640 650 660 IALGDEDPNE VLRKHVSDQI GAIAKPRRVF VVHELPKTRS GKIMRRLLRD VAEGRAIGDT 670 TTLADTQVMH VISDRMSAG

References

[1]

"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity." Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C. , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D. J. Bacteriol. 190:2138-2149(2008) [PubMed: 18192381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM711867 Genomic DNA. Translation: CAN00959.1.
RefSeq	YP_001221662.1. NC_009480.1.
3D structure databases
ProteinModelPortal	A5CPG1.
ModBase	Search...
Protein-protein interaction databases
STRING	A5CPG1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5173569.
GenomeReviews	Gene locus CMM_0922 in contig AM711867_GR.
KEGG	cmi:CMM_0922.
PATRIC	21452577. VBIClaMic82482_1018.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0365.
HOGENOM	HBG547964.
OMA	SHISSME.
ProtClustDB	CLSK2325109.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5CPG1_CLAM3

Accession

Primary (citable) accession number: A5CPG1

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)