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Protein

Xylose isomerase

Gene

xylA

Organism
Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei54 – 541UniRule annotation
Active sitei57 – 571UniRule annotation
Metal bindingi181 – 1811Magnesium 1UniRule annotation
Metal bindingi217 – 2171Magnesium 1UniRule annotation
Metal bindingi217 – 2171Magnesium 2UniRule annotation
Metal bindingi220 – 2201Magnesium 2UniRule annotation
Metal bindingi245 – 2451Magnesium 1UniRule annotation
Metal bindingi255 – 2551Magnesium 2UniRule annotation
Metal bindingi257 – 2571Magnesium 2UniRule annotation
Metal bindingi293 – 2931Magnesium 1UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. xylose isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-xylose metabolic process Source: UniProtKB-HAMAP
  2. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciCMIC443906:GCI2-907-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomeraseUniRule annotation (EC:5.3.1.5UniRule annotation)
Gene namesi
Name:xylAUniRule annotation
Ordered Locus Names:CMM_0882
OrganismiClavibacter michiganensis subsp. michiganensis (strain NCPPB 382)
Taxonomic identifieri443906 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeMicrobacteriaceaeClavibacter
ProteomesiUP000001564: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Xylose isomerasePRO_1000026438Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi443906.CMM_0882.

Structurei

3D structure databases

ProteinModelPortaliA5CPC1.
SMRiA5CPC1. Positions 6-396.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000022596.
KOiK01805.
OMAiYDIRFAI.
OrthoDBiEOG62NX4R.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5CPC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALTPTREDK FSFGLWTIGY TGADPFGGPT RSDLDVVEGV ERISELGAYG
60 70 80 90 100
LTFHDDDLFA FGSTDAERQT QIDRLKGALS DTGIVVPMVT TNLFSAPVFK
110 120 130 140 150
DGGFTSNDRA VRRFAIRKVL RNIDLAAELG AQTFVMWGGR EGAEYDSAKD
160 170 180 190 200
VRGALERYRE AVNLLGDYVT DKGYDIRFAI EPKPNEPRGD ILLPTLGHAL
210 220 230 240 250
AFIETLERPE LVGVNPEVGH EQMAGLNFTA GIMQALYQGK LFHIDLNGQR
260 270 280 290 300
GIKYDQDLVF GHGDLQNAFS LVDLLENGGV GGGRSYDGPR HFDYKPSRTE
310 320 330 340 350
DITGVWDSAA ANMRMYLLLK ERAQAFRADP EVQEALAAAK VQEIYTPTLN
360 370 380 390
EGESYDDILA DRSSYEDFDA PSYFDAKGFG FVRLNQLALE HLMGARS
Length:397
Mass (Da):43,837
Last modified:June 12, 2007 - v1
Checksum:i2841ADD244D09F38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM711867 Genomic DNA. Translation: CAN00919.1.
RefSeqiWP_012037567.1. NC_009480.1.
YP_001221622.1. NC_009480.1.

Genome annotation databases

EnsemblBacteriaiCAN00919; CAN00919; CMM_0882.
GeneIDi5173138.
KEGGicmi:CMM_0882.
PATRICi21452489. VBIClaMic82482_0976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM711867 Genomic DNA. Translation: CAN00919.1.
RefSeqiWP_012037567.1. NC_009480.1.
YP_001221622.1. NC_009480.1.

3D structure databases

ProteinModelPortaliA5CPC1.
SMRiA5CPC1. Positions 6-396.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi443906.CMM_0882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAN00919; CAN00919; CMM_0882.
GeneIDi5173138.
KEGGicmi:CMM_0882.
PATRICi21452489. VBIClaMic82482_0976.

Phylogenomic databases

eggNOGiCOG2115.
HOGENOMiHOG000022596.
KOiK01805.
OMAiYDIRFAI.
OrthoDBiEOG62NX4R.

Enzyme and pathway databases

BioCyciCMIC443906:GCI2-907-MONOMER.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013453. XylA_actinobac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02631. xylA_Arthro. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity."
    Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C.
    , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D.
    J. Bacteriol. 190:2138-2149(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCPPB 382.

Entry informationi

Entry nameiXYLA_CLAM3
AccessioniPrimary (citable) accession number: A5CPC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 12, 2007
Last modified: February 4, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.