A5CPB7 (ARAA_CLAM3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase
EC=5.3.1.4

Gene names

Name:	araA
Ordered Locus Names:	CMM_0878

Organism

Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [Complete proteome] [HAMAP]

Taxonomic identifier

443906 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 505	505	L-arabinose isomerase HAMAP MF_00519		PRO_0000312605
Sites
	Metal binding	310	1	Manganese By similarity
	Metal binding	337	1	Manganese By similarity
	Metal binding	354	1	Manganese By similarity
	Metal binding	453	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5CPB7 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 2FC0C330339E01E6	FASTA	505	55,444
	10 20 30 40 50 60 MSRITTSLDH YEVWFLTGSQ NLYGEETLQQ VAEQSQEIAR QLEEASDIPV RVVWKPVLKD 70 80 90 100 110 120 SDSIRRMALE ANASDGTIGL IAWMHTFSPA KMWIQGLDAL QKPFLHLHTQ ANVALPWSSI 130 140 150 160 170 180 DMDFMNLNQA AHGDREFGYI QSRLGVVRKT VVGHVSTESV RASIGTWMRA AAGWAAVHEL 190 200 210 220 230 240 KVARFGDNMR NVAVTEGDKT EAELKFGVSV NTWGVNDLVA RVDAATDAEI DALVDEYETL 250 260 270 280 290 300 YDIQPELRRG GERHESLRYG AAIELGLRSF LEEGGFGAFT TSFEDLGGLR QLPGLAVQRL 310 320 330 340 350 360 MAEGYGFGAE GDWKTAVLIR AAKVMGSGLP GGASLMEDYT YHLVPGEEKI LGAHMLEICP 370 380 390 400 410 420 TLTTGRPSLE IHPLGIGGRE DPVRLVFDTD PGPAVVVAMS DMRDRFRIVA NVVEVVPLDE 430 440 450 460 470 480 PLPNLPVARA VWKPAPDLAT SAAAWLTAGA AHHTVMSTQV GVEVFEDFAE IARTELLVID 490 500 EDTTLKGFTK EVRWNQAYHR LAQGL

References

[1]

"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity." Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C. , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D. J. Bacteriol. 190:2138-2149(2008) [PubMed: 18192381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: NCPPB 382.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM711867 Genomic DNA. Translation: CAN00915.1.
RefSeq	YP_001221618.1. NC_009480.1.
3D structure databases
ProteinModelPortal	A5CPB7.
SMR	A5CPB7. Positions 6-501.
ModBase	Search...
Protein-protein interaction databases
STRING	A5CPB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5173360.
GenomeReviews	Gene locus CMM_0878 in contig AM711867_GR.
KEGG	cmi:CMM_0878.
PATRIC	21452481. VBIClaMic82482_0972.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2160.
HOGENOM	HBG297198.
OMA	IASESIK.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	CMIC443906:CMM_0878-MONOMER.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA_CLAM3

Accession

Primary (citable) accession number: A5CPB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program