A5CN79 (A5CN79_CLAM3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Ordered Locus Names:

CMM_0492

Organism

Clavibacter michiganensis subsp. michiganensis (strain NCPPB 382) [Complete proteome] [HAMAP] EMBL CAN00516.1

Taxonomic identifier

443906 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Microbacteriaceae › Clavibacter

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: InterPro tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5CN79 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 0C68ADD544F0FB4B	FASTA	414	44,600
	10 20 30 40 50 60 MTPDARGTDA PSRPLPSAAE LDARDPLARF RDLFVQSDDV VAYLDGNSLG RPTLASVDRV 70 80 90 100 110 120 ADFVRDGWGG RLIRGWDEDW LAMPTRIGDD LGRVTYGAAP GQTFVGDSTT VILYKLVRAA 130 140 150 160 170 180 VRARPGRDEL VIDTDNFPTD RFVLEGVAEE CGMTIRWIDV APDAGVTPEL VADAVGERTA 190 200 210 220 230 240 LVVLSQVAYR SGFLADVPAI TRLVHDAGAL VLWDTCHSVG VIPTELDAWG VDLAVGCSYK 250 260 270 280 290 300 YLDGGPGAPA HGYVRSDLQA ELRQPIQGWM GAQDVFAMGP EYVPADGIRR FLSGTPPIVG 310 320 330 340 350 360 MLAMQDMLAL IEEAGMPAIR AKSLALTGFA LDLVDRDLVP LGARVASPRE EDRRGSHVSV 370 380 390 400 410 DHPRFRDIVG ALWAEGVIPD FRAPSGLRLG LSPLTTSFRE VEVGVEAIRR HLAG

References

[1]

"The genome sequence of the tomato-pathogenic actinomycete Clavibacter michiganensis subsp. michiganensis NCPPB382 reveals a large island involved in pathogenicity." Gartemann K.-H., Abt B., Bekel T., Burger A., Engemann J., Fluegel M., Gaigalat L., Goesmann A., Graefen I., Kalinowski J., Kaup O., Kirchner O., Krause L., Linke B., McHardy A., Meyer F., Pohle S., Rueckert C. , Schneiker S., Zellermann E.-M., Puehler A., Eichenlaub R., Kaiser O., Bartels D. J. Bacteriol. 190:2138-2149(2008) [PubMed: 18192381] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM711867 Genomic DNA. Translation: CAN00516.1.
RefSeq	YP_001221232.1. NC_009480.1.
3D structure databases
ProteinModelPortal	A5CN79.
ModBase	Search...
Protein-protein interaction databases
STRING	A5CN79.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5175464.
GenomeReviews	Gene locus CMM_0492 in contig AM711867_GR.
KEGG	cmi:CMM_0492.
PATRIC	21451667. VBIClaMic82482_0571.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3844.
HOGENOM	HBG523016.
OMA	RGSQVSF.
ProtClustDB	CLSK956672.
Family and domain databases
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K01556.
PANTHER	PTHR14084. Kynureninase. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5CN79_CLAM3

Accession

Primary (citable) accession number: A5CN79

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)