ID   A5CKE2_HUMAN            Unreviewed;       639 AA.
AC   A5CKE2;
DT   12-JUN-2007, integrated into UniProtKB/TrEMBL.
DT   12-JUN-2007, sequence version 1.
DT   27-MAR-2024, entry version 110.
DE   SubName: Full=Platelet glycoprotein Ib alpha {ECO:0000313|EMBL:BAJ15421.1, ECO:0000313|EMBL:CAM97225.1};
DE   Flags: Fragment;
GN   Name=GP1BA {ECO:0000313|EMBL:CAM97225.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAM97225.1};
RN   [1] {ECO:0000313|EMBL:CAM97225.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=170743 {ECO:0000313|EMBL:CAM97225.1};
RA   Witter K.;
RT   "An additional 39 bp repeat detected in the human platelet glycoprotein Ib
RT   alpha sequence.";
RL   Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACY72565.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu L., Peng B., Yu S., Liu L., Zhang D., Sun G., Wang P., Sun N., Hu Q.,
RA   Li X., Cao F.;
RT   "Single Novel Mutation in Transmembrane Region of Glycoprotein IX Affects
RT   Platelet Surface Expressions of Glycoprotein GP-Ib-IX Complex and Causes
RT   Bernard Soulier Syndrome.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:BAJ15421.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23414566; DOI=10.1016/j.thromres.2013.01.014;
RA   Yamamoto N., Akamatsu N., Sakuraba H., Matsuno K., Hosoya R., Nogami H.,
RA   Kasahara K., Mitsuyama S., Arai M.;
RT   "Novel Bernard-Soulier syndrome variants caused by compound heterozygous
RT   mutations (case I) or a cytoplasmic tail truncation (case II) of GPIb?";
RL   Thromb. Res. 131:e160-e167(2013).
CC   -!- INTERACTION:
CC       A5CKE2; P0DTC2: S; Xeno; NbExp=3; IntAct=EBI-28956381, EBI-25474821;
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DR   EMBL; GU133003; ACY72565.1; -; Genomic_DNA.
DR   EMBL; AB576655; BAJ15421.1; -; Genomic_DNA.
DR   EMBL; AM709890; CAM97225.1; -; Genomic_DNA.
DR   AlphaFoldDB; A5CKE2; -.
DR   IntAct; A5CKE2; 1.
DR   PeptideAtlas; A5CKE2; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   PANTHER; PTHR46473:SF21; ELRR (EXTRACELLULAR LEUCINE-RICH REPEAT) ONLY; 1.
DR   PANTHER; PTHR46473; GH08155P; 1.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF01462; LRRNT; 1.
DR   PRINTS; PR00019; LEURICHRPT.
DR   SMART; SM00364; LRR_BAC; 4.
DR   SMART; SM00369; LRR_TYP; 5.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 2.
PE   1: Evidence at protein level;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..639
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010103128"
FT   TRANSMEM        518..542
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          19..51
FT                   /note="LRRNT"
FT                   /evidence="ECO:0000259|SMART:SM00013"
FT   DOMAIN          221..281
FT                   /note="LRRCT"
FT                   /evidence="ECO:0000259|SMART:SM00082"
FT   REGION          336..446
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..385
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        386..444
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         639
FT                   /evidence="ECO:0000313|EMBL:CAM97225.1"
SQ   SEQUENCE   639 AA;  70248 MW;  387BFD59BE431A60 CRC64;
     MPLLLLLLLL PSPLHPHPIC EVSKVASHLE VNCDKRNLTA LPPDLPKDTT ILHLSENLLY
     TFSLATLMPY TRLTQLNLDR CELTKLQVDG TLPVLGTLDL SHNQLQSLPL LGQTLPALTV
     LDVSFNRLTS LPLGALRGLG ELQELYLKGN ELKTLPPGLL TPTPKLEKLS LANNNLTELP
     AGLLNGLENL DTLLLQENSL YTIPKGFFGS HLLPFAFLHG NPWLCNCEIL YFRRWLQDNA
     ENVYVWKQGV DVKAMTSNVA SVQCDNSDKF PVYKYPGKGC PTLGDEGDTD LYDYYPEEDT
     EGDKVRATRT VVKFPTKAHT TPWGLFYSWS TASLDSQMPS SLHPTQESTK EQTTFPPRWT
     PNFTLHMESI TFSKTPKSTT EPTPSPTTSE PVPEPAPNMT TLEPTPSPTT PEPTSEPAPS
     PTTPEPTSEP APSPTTPEPT PIPTIATSPT ILVSATSLIT PKSTFLTTTK PVSLLESTKK
     TIPELDQPPK LRGVLQGHLE SSRNDPFLHP DFCCLLPLGF YVLGLFWLLF ASVVLILLLS
     WVGHVKPQAL DSGQGAALTT ATQTTHLELQ RGRQVTVPRA WLLFLRGSLP TFRSSLFLWV
     RPNGRVGPLV AGRRPSALSQ GRGQDLLSTV SIRYSGHSL
//