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A5CKE2

- A5CKE2_HUMAN

UniProt

A5CKE2 - A5CKE2_HUMAN

Protein
Submitted name:

Platelet glycoprotein Ib alpha

Gene

GP1BA

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. blood coagulation Source: Ensembl
    2. cell morphogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Platelet glycoprotein Ib alphaImported
    Submitted name:
    Platelet glycoprotein Ib alpha polypeptideImported
    Gene namesi
    Name:GP1BAImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. anchored component of external side of plasma membrane Source: Ensembl

    PTM / Processingi

    Proteomic databases

    PRIDEiA5CKE2.

    Miscellaneous databases

    PMAP-CutDBA5CKE2.

    Expressioni

    Gene expression databases

    ArrayExpressiA5CKE2.

    Structurei

    3D structure databases

    ProteinModelPortaliA5CKE2.
    SMRiA5CKE2. Positions 17-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000234361.
    HOVERGENiHBG051790.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    A5CKE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLLLLLLLL PSPLHPHPIC EVSKVASHLE VNCDKRNLTA LPPDLPKDTT    50
    ILHLSENLLY TFSLATLMPY TRLTQLNLDR CELTKLQVDG TLPVLGTLDL 100
    SHNQLQSLPL LGQTLPALTV LDVSFNRLTS LPLGALRGLG ELQELYLKGN 150
    ELKTLPPGLL TPTPKLEKLS LANNNLTELP AGLLNGLENL DTLLLQENSL 200
    YTIPKGFFGS HLLPFAFLHG NPWLCNCEIL YFRRWLQDNA ENVYVWKQGV 250
    DVKAMTSNVA SVQCDNSDKF PVYKYPGKGC PTLGDEGDTD LYDYYPEEDT 300
    EGDKVRATRT VVKFPTKAHT TPWGLFYSWS TASLDSQMPS SLHPTQESTK 350
    EQTTFPPRWT PNFTLHMESI TFSKTPKSTT EPTPSPTTSE PVPEPAPNMT 400
    TLEPTPSPTT PEPTSEPAPS PTTPEPTSEP APSPTTPEPT PIPTIATSPT 450
    ILVSATSLIT PKSTFLTTTK PVSLLESTKK TIPELDQPPK LRGVLQGHLE 500
    SSRNDPFLHP DFCCLLPLGF YVLGLFWLLF ASVVLILLLS WVGHVKPQAL 550
    DSGQGAALTT ATQTTHLELQ RGRQVTVPRA WLLFLRGSLP TFRSSLFLWV 600
    RPNGRVGPLV AGRRPSALSQ GRGQDLLSTV SIRYSGHSL 639
    Length:639
    Mass (Da):70,248
    Last modified:June 12, 2007 - v1
    Checksum:i387BFD59BE431A60
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei639 – 6391Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GU133003 Genomic DNA. Translation: ACY72565.1.
    AB576655 Genomic DNA. Translation: BAJ15421.1.
    AM709890 Genomic DNA. Translation: CAM97225.1.
    UniGeneiHs.1472.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GU133003 Genomic DNA. Translation: ACY72565.1 .
    AB576655 Genomic DNA. Translation: BAJ15421.1 .
    AM709890 Genomic DNA. Translation: CAM97225.1 .
    UniGenei Hs.1472.

    3D structure databases

    ProteinModelPortali A5CKE2.
    SMRi A5CKE2. Positions 17-300.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A5CKE2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000234361.
    HOVERGENi HBG051790.

    Miscellaneous databases

    NextBioi 27032107.
    PMAP-CutDB A5CKE2.

    Gene expression databases

    ArrayExpressi A5CKE2.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An additional 39 bp repeat detected in the human platelet glycoprotein Ib alpha sequence."
      Witter K.
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 170743Imported.
    2. "Single Novel Mutation in Transmembrane Region of Glycoprotein IX Affects Platelet Surface Expressions of Glycoprotein GP-Ib-IX Complex and Causes Bernard Soulier Syndrome."
      Xu L., Peng B., Yu S., Liu L., Zhang D., Sun G., Wang P., Sun N., Hu Q., Li X., Cao F.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Novel Bernard-Soulier syndrome variants caused by compound heterozygous mutations (case I) or a cytoplasmic tail truncation (case II) of GPIb?"
      Yamamoto N., Akamatsu N., Sakuraba H., Matsuno K., Hosoya R., Nogami H., Kasahara K., Mitsuyama S., Arai M.
      Thromb. Res. 131:e160-e167(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiA5CKE2_HUMAN
    AccessioniPrimary (citable) accession number: A5CKE2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 12, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.