A5CKE2 (A5CKE2_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Platelet glycoprotein Ib alpha EMBL BAJ15421.1

Submitted name:
Platelet glycoprotein Ib alpha polypeptide EMBL CAM97225.1

Gene names

Name:

GP1BA EMBL CAM97225.1

Organism

Homo sapiens (Human) EMBL CAM97225.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	639 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Leucine-rich repeat SAAS SAAS000483 Repeat SAAS SAAS000483
Gene Ontology (GO)
Biological_process	cell morphogenesis Inferred from electronic annotation. Source: Compara hemostasis Inferred from electronic annotation. Source: Compara
Cellular_component	anchored to external side of plasma membrane Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	639	1	EMBL CAM97225.1

Sequences

	Sequence		Length	Mass (Da)
	A5CKE2 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 387BFD59BE431A60	FASTA	639	70,248
	10 20 30 40 50 60 MPLLLLLLLL PSPLHPHPIC EVSKVASHLE VNCDKRNLTA LPPDLPKDTT ILHLSENLLY 70 80 90 100 110 120 TFSLATLMPY TRLTQLNLDR CELTKLQVDG TLPVLGTLDL SHNQLQSLPL LGQTLPALTV 130 140 150 160 170 180 LDVSFNRLTS LPLGALRGLG ELQELYLKGN ELKTLPPGLL TPTPKLEKLS LANNNLTELP 190 200 210 220 230 240 AGLLNGLENL DTLLLQENSL YTIPKGFFGS HLLPFAFLHG NPWLCNCEIL YFRRWLQDNA 250 260 270 280 290 300 ENVYVWKQGV DVKAMTSNVA SVQCDNSDKF PVYKYPGKGC PTLGDEGDTD LYDYYPEEDT 310 320 330 340 350 360 EGDKVRATRT VVKFPTKAHT TPWGLFYSWS TASLDSQMPS SLHPTQESTK EQTTFPPRWT 370 380 390 400 410 420 PNFTLHMESI TFSKTPKSTT EPTPSPTTSE PVPEPAPNMT TLEPTPSPTT PEPTSEPAPS 430 440 450 460 470 480 PTTPEPTSEP APSPTTPEPT PIPTIATSPT ILVSATSLIT PKSTFLTTTK PVSLLESTKK 490 500 510 520 530 540 TIPELDQPPK LRGVLQGHLE SSRNDPFLHP DFCCLLPLGF YVLGLFWLLF ASVVLILLLS 550 560 570 580 590 600 WVGHVKPQAL DSGQGAALTT ATQTTHLELQ RGRQVTVPRA WLLFLRGSLP TFRSSLFLWV 610 620 630 RPNGRVGPLV AGRRPSALSQ GRGQDLLSTV SIRYSGHSL

References

[1]	"An additional 39 bp repeat detected in the human platelet glycoprotein Ib alpha sequence." Witter K. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 170743 EMBL CAM97225.1.
[2]	"Single Novel Mutation in Transmembrane Region of Glycoprotein IX Affects Platelet Surface Expressions of Glycoprotein GP-Ib-IX Complex and Causes Bernard Soulier Syndrome." Xu L., Peng B., Yu S., Liu L., Zhang D., Sun G., Wang P., Sun N., Hu Q., Li X., Cao F. Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Mutations in glycoprotein Ib alpha gene from 2 families with Bernard-Soulier syndrome in Tokyo." Yamamoto N. Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GU133003 Genomic DNA. Translation: ACY72565.1. AB576655 Genomic DNA. Translation: BAJ15421.1. AM709890 Genomic DNA. Translation: CAM97225.1.
IPI	IPI00748955.
UniGene	Hs.1472.
3D structure databases
ProteinModelPortal	A5CKE2.
SMR	A5CKE2. Positions 17-300.
ModBase	Search...
Protein-protein interaction databases
STRING	A5CKE2.
Proteomic databases
PRIDE	A5CKE2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000234361.
HOVERGEN	HBG051790.
PhylomeDB	A5CKE2.
Gene expression databases
ArrayExpress	A5CKE2.
Bgee	A5CKE2.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF00560. LRR_1. 1 hit. PF01462. LRRNT. 1 hit. [Graphical view]
SMART	SM00369. LRR_TYP. 2 hits. SM00082. LRRCT. 1 hit. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS51450. LRR. 6 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	27032107.
PMAP-CutDB	A5CKE2.

Entry information

Entry name

A5CKE2_HUMAN

Accession

Primary (citable) accession number: A5CKE2

Entry history

Integrated into UniProtKB/TrEMBL:	June 12, 2007
Last sequence update:	June 12, 2007
Last modified:	April 3, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.