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A5CKE2

- A5CKE2_HUMAN

UniProt

A5CKE2 - A5CKE2_HUMAN

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Protein
Submitted name:

Platelet glycoprotein Ib alpha

Gene

GP1BA

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. blood coagulation Source: Ensembl
  2. cell morphogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Platelet glycoprotein Ib alphaImported
Submitted name:
Platelet glycoprotein Ib alpha polypeptideImported
Gene namesi
Name:GP1BAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. anchored component of external side of plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiA5CKE2.

Miscellaneous databases

PMAP-CutDBA5CKE2.

Expressioni

Gene expression databases

ExpressionAtlasiA5CKE2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA5CKE2.
SMRiA5CKE2. Positions 17-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

HOGENOMiHOG000234361.
HOVERGENiHBG051790.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A5CKE2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MPLLLLLLLL PSPLHPHPIC EVSKVASHLE VNCDKRNLTA LPPDLPKDTT
60 70 80 90 100
ILHLSENLLY TFSLATLMPY TRLTQLNLDR CELTKLQVDG TLPVLGTLDL
110 120 130 140 150
SHNQLQSLPL LGQTLPALTV LDVSFNRLTS LPLGALRGLG ELQELYLKGN
160 170 180 190 200
ELKTLPPGLL TPTPKLEKLS LANNNLTELP AGLLNGLENL DTLLLQENSL
210 220 230 240 250
YTIPKGFFGS HLLPFAFLHG NPWLCNCEIL YFRRWLQDNA ENVYVWKQGV
260 270 280 290 300
DVKAMTSNVA SVQCDNSDKF PVYKYPGKGC PTLGDEGDTD LYDYYPEEDT
310 320 330 340 350
EGDKVRATRT VVKFPTKAHT TPWGLFYSWS TASLDSQMPS SLHPTQESTK
360 370 380 390 400
EQTTFPPRWT PNFTLHMESI TFSKTPKSTT EPTPSPTTSE PVPEPAPNMT
410 420 430 440 450
TLEPTPSPTT PEPTSEPAPS PTTPEPTSEP APSPTTPEPT PIPTIATSPT
460 470 480 490 500
ILVSATSLIT PKSTFLTTTK PVSLLESTKK TIPELDQPPK LRGVLQGHLE
510 520 530 540 550
SSRNDPFLHP DFCCLLPLGF YVLGLFWLLF ASVVLILLLS WVGHVKPQAL
560 570 580 590 600
DSGQGAALTT ATQTTHLELQ RGRQVTVPRA WLLFLRGSLP TFRSSLFLWV
610 620 630
RPNGRVGPLV AGRRPSALSQ GRGQDLLSTV SIRYSGHSL
Length:639
Mass (Da):70,248
Last modified:June 12, 2007 - v1
Checksum:i387BFD59BE431A60
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei639 – 6391Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GU133003 Genomic DNA. Translation: ACY72565.1.
AB576655 Genomic DNA. Translation: BAJ15421.1.
AM709890 Genomic DNA. Translation: CAM97225.1.
UniGeneiHs.1472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GU133003 Genomic DNA. Translation: ACY72565.1 .
AB576655 Genomic DNA. Translation: BAJ15421.1 .
AM709890 Genomic DNA. Translation: CAM97225.1 .
UniGenei Hs.1472.

3D structure databases

ProteinModelPortali A5CKE2.
SMRi A5CKE2. Positions 17-300.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A5CKE2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000234361.
HOVERGENi HBG051790.

Miscellaneous databases

NextBioi 27032107.
PMAP-CutDB A5CKE2.

Gene expression databases

ExpressionAtlasi A5CKE2. baseline and differential.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "An additional 39 bp repeat detected in the human platelet glycoprotein Ib alpha sequence."
    Witter K.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 170743Imported.
  2. "Single Novel Mutation in Transmembrane Region of Glycoprotein IX Affects Platelet Surface Expressions of Glycoprotein GP-Ib-IX Complex and Causes Bernard Soulier Syndrome."
    Xu L., Peng B., Yu S., Liu L., Zhang D., Sun G., Wang P., Sun N., Hu Q., Li X., Cao F.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Novel Bernard-Soulier syndrome variants caused by compound heterozygous mutations (case I) or a cytoplasmic tail truncation (case II) of GPIb?"
    Yamamoto N., Akamatsu N., Sakuraba H., Matsuno K., Hosoya R., Nogami H., Kasahara K., Mitsuyama S., Arai M.
    Thromb. Res. 131:e160-e167(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiA5CKE2_HUMAN
AccessioniPrimary (citable) accession number: A5CKE2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 12, 2007
Last sequence update: June 12, 2007
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.