A5CFN1 (DCD_ORITB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Deoxycytidine triphosphate deaminase
Short name=dCTP deaminase
EC=3.5.4.13

Gene names

Name:	dcd
Ordered Locus Names:	OTBS_2156

Organism

Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi) [Complete proteome] [HAMAP]

Taxonomic identifier

357244 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Orientia

Protein attributes

Sequence length	188 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	dCTP + H2O = dUTP + NH3. HAMAP MF_00146
Pathway	Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2. HAMAP MF_00146
Sequence similarities	Belongs to the dCTP deaminase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	dUTP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	dCTP deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 188	188	Deoxycytidine triphosphate deaminase HAMAP MF_00146		PRO_1000009777

Sequences

	Sequence		Length	Mass (Da)
	A5CFN1 [UniParc]. Last modified June 12, 2007. Version 1. Checksum: 3F56A8612CEFF880	FASTA	188	21,151
	10 20 30 40 50 60 MSIMSDNWIK KMAESKNMIS PFVDKQVRAR NNQQILSYGL SSYGYDARVS NEFKIFTNTK 70 80 90 100 110 120 PSIIDPKKFD QDCLITKISD ICIIPPNSFA LGTTIEYFKM PRDVIAICIG KSTYARCGII 130 140 150 160 170 180 INVTPLEPEC EGHITLEFSN TTPLPAKIYA GEGACQFLFF KGDQPCNTSY LDRYGRYTKQ IGVTLPTV

References

[1]

"The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes." Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S. Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007) [PubMed: 17483455] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Boryong.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM494475 Genomic DNA. Translation: CAM81251.1.
RefSeq	YP_001249248.1. NC_009488.1.
3D structure databases
ProteinModelPortal	A5CFN1.
ModBase	Search...
Protein-protein interaction databases
STRING	A5CFN1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5219198.
GenomeReviews	Gene locus OTBS_2156 in contig AM494475_GR.
KEGG	ots:OTBS_2156.
PATRIC	22825877. VBIOriTsu83812_2343.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0717.
HOGENOM	HBG553199.
OMA	IFRHIPG.
ProtClustDB	PRK00416.
Enzyme and pathway databases
BioCyc	OTSU357244:OTBS_2156-MONOMER.
Family and domain databases
HAMAP	MF_00146. dCTP_deaminase. [Tree]
InterPro	IPR011962. dCTP_deam. IPR008180. dUTP_pyroPase. [Graphical view]
KO	K01494.
Pfam	PF00692. dUTPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR02274. DCTP_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DCD_ORITB

Accession

Primary (citable) accession number: A5CFN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 12, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program