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A5CF65

- DEF_ORITB

UniProt

A5CF65 - DEF_ORITB

Protein

Peptide deformylase

Gene

def

Organism
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

    Catalytic activityi

    Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

    Cofactori

    Binds 1 Fe2+ ion.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi103 – 1031IronUniRule annotation
    Metal bindingi145 – 1451IronUniRule annotation
    Active sitei146 – 1461UniRule annotation
    Metal bindingi149 – 1491IronUniRule annotation

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. peptide deformylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciOTSU357244:GCA5-1881-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
    Short name:
    PDFUniRule annotation
    Alternative name(s):
    Polypeptide deformylaseUniRule annotation
    Gene namesi
    Name:defUniRule annotation
    Ordered Locus Names:OTBS_1849
    OrganismiOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
    Taxonomic identifieri357244 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
    ProteomesiUP000001565: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Peptide deformylasePRO_0000301072Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi357244.OTBS_1849.

    Structurei

    3D structure databases

    ProteinModelPortaliA5CF65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the polypeptide deformylase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0242.
    HOGENOMiHOG000243509.
    KOiK01462.
    OMAiQQANNST.
    OrthoDBiEOG664CMF.

    Family and domain databases

    Gene3Di3.90.45.10. 1 hit.
    HAMAPiMF_00163. Pep_deformylase.
    InterProiIPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view]
    PANTHERiPTHR10458. PTHR10458. 1 hit.
    PfamiPF01327. Pep_deformylase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004749. Pep_def. 1 hit.
    PRINTSiPR01576. PDEFORMYLASE.
    SUPFAMiSSF56420. SSF56420. 1 hit.
    TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5CF65-1 [UniParc]FASTAAdd to Basket

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    MSILSLVTAP DPILKKVSSP VDTVNDSIRQ LIDDMLETMY HNHGVGLAAP    50
    QVAVSKRIIV LDLSKVDIEE DNITNSEYKY PLFMVNPIVK AISNQTVTAK 100
    EGCLSLPKQA IEVSRYHEIQ VTYLDYYNKL KTLNAAGWLA RAIQHEVDHL 150
    DGILLVDYLS NLKKEATLNT LSKIKDAAYD K 181
    Length:181
    Mass (Da):20,240
    Last modified:June 12, 2007 - v1
    Checksum:i6826C003DB7FCDD9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM494475 Genomic DNA. Translation: CAM80944.1.
    RefSeqiYP_001249099.1. NC_009488.1.

    Genome annotation databases

    EnsemblBacteriaiCAM80944; CAM80944; OTBS_1849.
    GeneIDi5218231.
    KEGGiots:OTBS_1849.
    PATRICi22825176. VBIOriTsu83812_1997.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM494475 Genomic DNA. Translation: CAM80944.1 .
    RefSeqi YP_001249099.1. NC_009488.1.

    3D structure databases

    ProteinModelPortali A5CF65.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357244.OTBS_1849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM80944 ; CAM80944 ; OTBS_1849 .
    GeneIDi 5218231.
    KEGGi ots:OTBS_1849.
    PATRICi 22825176. VBIOriTsu83812_1997.

    Phylogenomic databases

    eggNOGi COG0242.
    HOGENOMi HOG000243509.
    KOi K01462.
    OMAi QQANNST.
    OrthoDBi EOG664CMF.

    Enzyme and pathway databases

    BioCyci OTSU357244:GCA5-1881-MONOMER.

    Family and domain databases

    Gene3Di 3.90.45.10. 1 hit.
    HAMAPi MF_00163. Pep_deformylase.
    InterProi IPR000181. Fmet_deformylase.
    IPR023635. Peptide_deformylase.
    [Graphical view ]
    PANTHERi PTHR10458. PTHR10458. 1 hit.
    Pfami PF01327. Pep_deformylase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004749. Pep_def. 1 hit.
    PRINTSi PR01576. PDEFORMYLASE.
    SUPFAMi SSF56420. SSF56420. 1 hit.
    TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes."
      Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.
      Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Boryong.

    Entry informationi

    Entry nameiDEF_ORITB
    AccessioniPrimary (citable) accession number: A5CF65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3