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A5CF57 (FENR_ORITB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferredoxin--NADP reductase

Short name=FNR
Short name=Fd-NADP(+) reductase
EC=1.18.1.2
Gene names
Ordered Locus Names:OTBS_1841
OrganismOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi) [Complete proteome] [HAMAP]
Taxonomic identifier357244 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH. HAMAP-Rule MF_01685

Cofactor

Binds 1 FAD per subunit By similarity. HAMAP-Rule MF_01685

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01685

Sequence similarities

Belongs to the ferredoxin--NADP reductase type 2 family.

Ontologies

Keywords
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionNADP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ferredoxin-NADP+ reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338Ferredoxin--NADP reductase HAMAP-Rule MF_01685
PRO_0000364891

Sites

Binding site381FAD By similarity
Binding site461FAD By similarity
Binding site511FAD By similarity
Binding site911FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site1251FAD; via amide nitrogen By similarity
Binding site2911FAD By similarity
Binding site3311FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A5CF57 [UniParc].

Last modified June 12, 2007. Version 1.
Checksum: 28661CED9F045B3E

FASTA33837,098
        10         20         30         40         50         60 
MLSKNVHTAD VVIVGAGPVG LFAVFQAGML EMKCHVVDAL DCIGGQCVTL YPDKPIYDIP 

        70         80         90        100        110        120 
AYPVITAAKL IEQLKQQVAP FDTVYHLGQQ VIGCKIDNDI ITITTSAEQV ICSKSLIIAA 

       130        140        150        160        170        180 
GCGAFKYKRL ILDNIEAFEN KTVFYSVKDK NKFINKKVVI AGGGDSAIDW TLLLSDVAEV 

       190        200        210        220        230        240 
IYLVHRRENF RCAPHSLNQI KQLAEYGKVQ MIVPYQLAKL TGENGLLQEV LVTNFNGGTQ 

       250        260        270        280        290        300 
TLPADYLLAF FGLAADLGPI HKWGLKTDLR RIEVNSITYE TTIPGIYAIG DVASYPGKLK 

       310        320        330 
LILTGFAEAA TAMSHCYQRV FGKKMHFQYS TVKGVLRS 

« Hide

References

[1]"The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes."
Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.
Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Boryong.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM494475 Genomic DNA. Translation: CAM80936.1.
RefSeqYP_001249091.1. NC_009488.1.

3D structure databases

ProteinModelPortalA5CF57.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING357244.OTBS_1841.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAM80936; CAM80936; OTBS_1841.
GeneID5218223.
KEGGots:OTBS_1841.
PATRIC22825158. VBIOriTsu83812_1988.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0492.
HOGENOMHOG000072909.
KOK00384.
OMALFQVFQL.
OrthoDBEOG661H9M.

Enzyme and pathway databases

BioCycOTSU357244:GCA5-1873-MONOMER.

Family and domain databases

HAMAPMF_01685. FENR2.
InterProIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
PR00469. PNDRDTASEII.
ProtoNetSearch...

Entry information

Entry nameFENR_ORITB
AccessionPrimary (citable) accession number: A5CF57
Entry history
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families