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A5CF57

- FENR_ORITB

UniProt

A5CF57 - FENR_ORITB

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Protein

Ferredoxin--NADP reductase

Gene

OTBS_1841

Organism
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.UniRule annotation

Cofactori

Binds 1 FAD per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381FADUniRule annotation
Binding sitei46 – 461FADUniRule annotation
Binding sitei51 – 511FADUniRule annotation
Binding sitei91 – 911FAD; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei125 – 1251FAD; via amide nitrogenUniRule annotation
Binding sitei291 – 2911FADUniRule annotation
Binding sitei331 – 3311FADUniRule annotation

GO - Molecular functioni

  1. ferredoxin-NADP+ reductase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. NADP binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciOTSU357244:GCA5-1873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin--NADP reductaseUniRule annotation (EC:1.18.1.2UniRule annotation)
Short name:
FNRUniRule annotation
Short name:
Fd-NADP(+) reductaseUniRule annotation
Gene namesi
Ordered Locus Names:OTBS_1841
OrganismiOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Taxonomic identifieri357244 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
ProteomesiUP000001565: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Ferredoxin--NADP reductasePRO_0000364891Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi357244.OTBS_1841.

Structurei

3D structure databases

ProteinModelPortaliA5CF57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0492.
HOGENOMiHOG000072909.
KOiK00384.
OMAiLFQVFQL.
OrthoDBiEOG661H9M.

Family and domain databases

HAMAPiMF_01685. FENR2.
InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
PR00469. PNDRDTASEII.

Sequencei

Sequence statusi: Complete.

A5CF57-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSKNVHTAD VVIVGAGPVG LFAVFQAGML EMKCHVVDAL DCIGGQCVTL
60 70 80 90 100
YPDKPIYDIP AYPVITAAKL IEQLKQQVAP FDTVYHLGQQ VIGCKIDNDI
110 120 130 140 150
ITITTSAEQV ICSKSLIIAA GCGAFKYKRL ILDNIEAFEN KTVFYSVKDK
160 170 180 190 200
NKFINKKVVI AGGGDSAIDW TLLLSDVAEV IYLVHRRENF RCAPHSLNQI
210 220 230 240 250
KQLAEYGKVQ MIVPYQLAKL TGENGLLQEV LVTNFNGGTQ TLPADYLLAF
260 270 280 290 300
FGLAADLGPI HKWGLKTDLR RIEVNSITYE TTIPGIYAIG DVASYPGKLK
310 320 330
LILTGFAEAA TAMSHCYQRV FGKKMHFQYS TVKGVLRS
Length:338
Mass (Da):37,098
Last modified:June 12, 2007 - v1
Checksum:i28661CED9F045B3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM494475 Genomic DNA. Translation: CAM80936.1.
RefSeqiWP_011945073.1. NC_009488.1.
YP_001249091.1. NC_009488.1.

Genome annotation databases

EnsemblBacteriaiCAM80936; CAM80936; OTBS_1841.
GeneIDi5218223.
KEGGiots:OTBS_1841.
PATRICi22825158. VBIOriTsu83812_1988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM494475 Genomic DNA. Translation: CAM80936.1 .
RefSeqi WP_011945073.1. NC_009488.1.
YP_001249091.1. NC_009488.1.

3D structure databases

ProteinModelPortali A5CF57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 357244.OTBS_1841.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAM80936 ; CAM80936 ; OTBS_1841 .
GeneIDi 5218223.
KEGGi ots:OTBS_1841.
PATRICi 22825158. VBIOriTsu83812_1988.

Phylogenomic databases

eggNOGi COG0492.
HOGENOMi HOG000072909.
KOi K00384.
OMAi LFQVFQL.
OrthoDBi EOG661H9M.

Enzyme and pathway databases

BioCyci OTSU357244:GCA5-1873-MONOMER.

Family and domain databases

HAMAPi MF_01685. FENR2.
InterProi IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view ]
Pfami PF07992. Pyr_redox_2. 1 hit.
[Graphical view ]
PRINTSi PR00368. FADPNR.
PR00469. PNDRDTASEII.
ProtoNeti Search...

Publicationsi

  1. "The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes."
    Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.
    Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Boryong.

Entry informationi

Entry nameiFENR_ORITB
AccessioniPrimary (citable) accession number: A5CF57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 12, 2007
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3