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Protein

Ferredoxin--NADP reductase

Gene

OTBS_1841

Organism
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381FADUniRule annotation
Binding sitei46 – 461FADUniRule annotation
Binding sitei51 – 511FADUniRule annotation
Binding sitei91 – 911FAD; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei125 – 1251FAD; via amide nitrogenUniRule annotation
Binding sitei291 – 2911FADUniRule annotation
Binding sitei331 – 3311FADUniRule annotation

GO - Molecular functioni

  1. ferredoxin-NADP+ reductase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. NADP binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Enzyme and pathway databases

BioCyciOTSU357244:GCA5-1873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin--NADP reductaseUniRule annotation (EC:1.18.1.2UniRule annotation)
Short name:
FNRUniRule annotation
Short name:
Fd-NADP(+) reductaseUniRule annotation
Gene namesi
Ordered Locus Names:OTBS_1841
OrganismiOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Taxonomic identifieri357244 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
ProteomesiUP000001565 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Ferredoxin--NADP reductasePRO_0000364891Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi357244.OTBS_1841.

Structurei

3D structure databases

ProteinModelPortaliA5CF57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0492.
HOGENOMiHOG000072909.
KOiK00384.
OMAiVIVNFGF.
OrthoDBiEOG661H9M.

Family and domain databases

HAMAPiMF_01685. FENR2.
InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
PR00469. PNDRDTASEII.

Sequencei

Sequence statusi: Complete.

A5CF57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKNVHTAD VVIVGAGPVG LFAVFQAGML EMKCHVVDAL DCIGGQCVTL
60 70 80 90 100
YPDKPIYDIP AYPVITAAKL IEQLKQQVAP FDTVYHLGQQ VIGCKIDNDI
110 120 130 140 150
ITITTSAEQV ICSKSLIIAA GCGAFKYKRL ILDNIEAFEN KTVFYSVKDK
160 170 180 190 200
NKFINKKVVI AGGGDSAIDW TLLLSDVAEV IYLVHRRENF RCAPHSLNQI
210 220 230 240 250
KQLAEYGKVQ MIVPYQLAKL TGENGLLQEV LVTNFNGGTQ TLPADYLLAF
260 270 280 290 300
FGLAADLGPI HKWGLKTDLR RIEVNSITYE TTIPGIYAIG DVASYPGKLK
310 320 330
LILTGFAEAA TAMSHCYQRV FGKKMHFQYS TVKGVLRS
Length:338
Mass (Da):37,098
Last modified:June 11, 2007 - v1
Checksum:i28661CED9F045B3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM494475 Genomic DNA. Translation: CAM80936.1.
RefSeqiWP_011945073.1. NC_009488.1.
YP_001249091.1. NC_009488.1.

Genome annotation databases

EnsemblBacteriaiCAM80936; CAM80936; OTBS_1841.
KEGGiots:OTBS_1841.
PATRICi22825158. VBIOriTsu83812_1988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM494475 Genomic DNA. Translation: CAM80936.1.
RefSeqiWP_011945073.1. NC_009488.1.
YP_001249091.1. NC_009488.1.

3D structure databases

ProteinModelPortaliA5CF57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi357244.OTBS_1841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM80936; CAM80936; OTBS_1841.
KEGGiots:OTBS_1841.
PATRICi22825158. VBIOriTsu83812_1988.

Phylogenomic databases

eggNOGiCOG0492.
HOGENOMiHOG000072909.
KOiK00384.
OMAiVIVNFGF.
OrthoDBiEOG661H9M.

Enzyme and pathway databases

BioCyciOTSU357244:GCA5-1873-MONOMER.

Family and domain databases

HAMAPiMF_01685. FENR2.
InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
PR00469. PNDRDTASEII.
ProtoNetiSearch...

Publicationsi

  1. "The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes."
    Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.
    Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Boryong.

Entry informationi

Entry nameiFENR_ORITB
AccessioniPrimary (citable) accession number: A5CF57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 2, 2009
Last sequence update: June 11, 2007
Last modified: March 31, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.