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A5CF57

- FENR_ORITB

UniProt

A5CF57 - FENR_ORITB

Protein

Ferredoxin--NADP reductase

Gene

OTBS_1841

Organism
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (12 Jun 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.UniRule annotation

    Cofactori

    Binds 1 FAD per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381FADUniRule annotation
    Binding sitei46 – 461FADUniRule annotation
    Binding sitei51 – 511FADUniRule annotation
    Binding sitei91 – 911FAD; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei125 – 1251FAD; via amide nitrogenUniRule annotation
    Binding sitei291 – 2911FADUniRule annotation
    Binding sitei331 – 3311FADUniRule annotation

    GO - Molecular functioni

    1. ferredoxin-NADP+ reductase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. NADP binding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Enzyme and pathway databases

    BioCyciOTSU357244:GCA5-1873-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferredoxin--NADP reductaseUniRule annotation (EC:1.18.1.2UniRule annotation)
    Short name:
    FNRUniRule annotation
    Short name:
    Fd-NADP(+) reductaseUniRule annotation
    Gene namesi
    Ordered Locus Names:OTBS_1841
    OrganismiOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
    Taxonomic identifieri357244 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
    ProteomesiUP000001565: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Ferredoxin--NADP reductasePRO_0000364891Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi357244.OTBS_1841.

    Structurei

    3D structure databases

    ProteinModelPortaliA5CF57.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ferredoxin--NADP reductase type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0492.
    HOGENOMiHOG000072909.
    KOiK00384.
    OMAiLFQVFQL.
    OrthoDBiEOG661H9M.

    Family and domain databases

    HAMAPiMF_01685. FENR2.
    InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR022890. Fd--NADP_Rdtase_type_2.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    [Graphical view]
    PfamiPF07992. Pyr_redox_2. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.
    PR00469. PNDRDTASEII.

    Sequencei

    Sequence statusi: Complete.

    A5CF57-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSKNVHTAD VVIVGAGPVG LFAVFQAGML EMKCHVVDAL DCIGGQCVTL    50
    YPDKPIYDIP AYPVITAAKL IEQLKQQVAP FDTVYHLGQQ VIGCKIDNDI 100
    ITITTSAEQV ICSKSLIIAA GCGAFKYKRL ILDNIEAFEN KTVFYSVKDK 150
    NKFINKKVVI AGGGDSAIDW TLLLSDVAEV IYLVHRRENF RCAPHSLNQI 200
    KQLAEYGKVQ MIVPYQLAKL TGENGLLQEV LVTNFNGGTQ TLPADYLLAF 250
    FGLAADLGPI HKWGLKTDLR RIEVNSITYE TTIPGIYAIG DVASYPGKLK 300
    LILTGFAEAA TAMSHCYQRV FGKKMHFQYS TVKGVLRS 338
    Length:338
    Mass (Da):37,098
    Last modified:June 12, 2007 - v1
    Checksum:i28661CED9F045B3E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM494475 Genomic DNA. Translation: CAM80936.1.
    RefSeqiWP_011945073.1. NC_009488.1.
    YP_001249091.1. NC_009488.1.

    Genome annotation databases

    EnsemblBacteriaiCAM80936; CAM80936; OTBS_1841.
    GeneIDi5218223.
    KEGGiots:OTBS_1841.
    PATRICi22825158. VBIOriTsu83812_1988.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM494475 Genomic DNA. Translation: CAM80936.1 .
    RefSeqi WP_011945073.1. NC_009488.1.
    YP_001249091.1. NC_009488.1.

    3D structure databases

    ProteinModelPortali A5CF57.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 357244.OTBS_1841.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAM80936 ; CAM80936 ; OTBS_1841 .
    GeneIDi 5218223.
    KEGGi ots:OTBS_1841.
    PATRICi 22825158. VBIOriTsu83812_1988.

    Phylogenomic databases

    eggNOGi COG0492.
    HOGENOMi HOG000072909.
    KOi K00384.
    OMAi LFQVFQL.
    OrthoDBi EOG661H9M.

    Enzyme and pathway databases

    BioCyci OTSU357244:GCA5-1873-MONOMER.

    Family and domain databases

    HAMAPi MF_01685. FENR2.
    InterProi IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR022890. Fd--NADP_Rdtase_type_2.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    IPR000103. Pyridine_nuc-diS_OxRdtase_2.
    [Graphical view ]
    Pfami PF07992. Pyr_redox_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    PR00469. PNDRDTASEII.
    ProtoNeti Search...

    Publicationsi

    1. "The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes."
      Cho N.-H., Kim H.-R., Lee J.-H., Kim S.-Y., Kim J., Cha S., Kim S.-Y., Darby A.C., Fuxelius H.-H., Yin J., Kim J.H., Kim J., Lee S.J., Koh Y.-S., Jang W.-J., Park K.-H., Andersson S.G.E., Choi M.-S., Kim I.-S.
      Proc. Natl. Acad. Sci. U.S.A. 104:7981-7986(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Boryong.

    Entry informationi

    Entry nameiFENR_ORITB
    AccessioniPrimary (citable) accession number: A5CF57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 3, 2009
    Last sequence update: June 12, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3