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Protein

Ferredoxin--NADP reductase

Gene

OTBS_1841

Organism
Orientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 reduced ferredoxin + NADP+ + H+ = 2 oxidized ferredoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38FADUniRule annotation1
Binding sitei46FADUniRule annotation1
Binding sitei51FADUniRule annotation1
Binding sitei91FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei125FAD; via amide nitrogenUniRule annotation1
Binding sitei291FADUniRule annotation1
Binding sitei331FADUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Ferredoxin--NADP reductaseUniRule annotation (EC:1.18.1.2UniRule annotation)
Short name:
FNRUniRule annotation
Short name:
Fd-NADP(+) reductaseUniRule annotation
Gene namesi
Ordered Locus Names:OTBS_1841
OrganismiOrientia tsutsugamushi (strain Boryong) (Rickettsia tsutsugamushi)
Taxonomic identifieri357244 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeOrientia
Proteomesi
  • UP000001565 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003648911 – 338Ferredoxin--NADP reductaseAdd BLAST338

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi357244.OTBS_1841.

Structurei

3D structure databases

ProteinModelPortaliA5CF57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAY. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072909.
KOiK00384.
OMAiLDYQTNI.
OrthoDBiPOG091H07EY.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_01685. FENR2. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 3 hits.

Sequencei

Sequence statusi: Complete.

A5CF57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSKNVHTAD VVIVGAGPVG LFAVFQAGML EMKCHVVDAL DCIGGQCVTL
60 70 80 90 100
YPDKPIYDIP AYPVITAAKL IEQLKQQVAP FDTVYHLGQQ VIGCKIDNDI
110 120 130 140 150
ITITTSAEQV ICSKSLIIAA GCGAFKYKRL ILDNIEAFEN KTVFYSVKDK
160 170 180 190 200
NKFINKKVVI AGGGDSAIDW TLLLSDVAEV IYLVHRRENF RCAPHSLNQI
210 220 230 240 250
KQLAEYGKVQ MIVPYQLAKL TGENGLLQEV LVTNFNGGTQ TLPADYLLAF
260 270 280 290 300
FGLAADLGPI HKWGLKTDLR RIEVNSITYE TTIPGIYAIG DVASYPGKLK
310 320 330
LILTGFAEAA TAMSHCYQRV FGKKMHFQYS TVKGVLRS
Length:338
Mass (Da):37,098
Last modified:June 12, 2007 - v1
Checksum:i28661CED9F045B3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM494475 Genomic DNA. Translation: CAM80936.1.
RefSeqiWP_011945073.1. NC_009488.1.

Genome annotation databases

EnsemblBacteriaiCAM80936; CAM80936; OTBS_1841.
KEGGiots:OTBS_1841.
PATRICi22825158. VBIOriTsu83812_1988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM494475 Genomic DNA. Translation: CAM80936.1.
RefSeqiWP_011945073.1. NC_009488.1.

3D structure databases

ProteinModelPortaliA5CF57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi357244.OTBS_1841.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAM80936; CAM80936; OTBS_1841.
KEGGiots:OTBS_1841.
PATRICi22825158. VBIOriTsu83812_1988.

Phylogenomic databases

eggNOGiENOG4105CAY. Bacteria.
COG0492. LUCA.
HOGENOMiHOG000072909.
KOiK00384.
OMAiLDYQTNI.
OrthoDBiPOG091H07EY.

Family and domain databases

Gene3Di3.50.50.60. 3 hits.
HAMAPiMF_01685. FENR2. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR022890. Fd--NADP_Rdtase_type_2.
IPR000103. Pyridine_nuc-diS_OxRdtase_2.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00469. PNDRDTASEII.
SUPFAMiSSF51905. SSF51905. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiFENR_ORITB
AccessioniPrimary (citable) accession number: A5CF57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: June 12, 2007
Last modified: November 2, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.